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  1. Long noncoding RNAs (lncRNAs) have emerged as important regulators in a variety of human diseases. The dysregulation of liver sinusoidal endothelial cell (LSEC) phenotype is a critical early event in the fibro...

    Authors: Ting Chen, Zhemin Shi, Yanmian Zhao, Xiaoxiang Meng, Sicong Zhao, Lina Zheng, Xiaohui Han, Zhimei Hu, Qingbin Yao, Huajiang Lin, Xiaoxiao Du, Kun Zhang, Tao Han and Wei Hong
    Citation: BMC Medicine 2022 20:335
  2. Studies often evaluate mental health and well-being in association with individual health behaviours although evaluating multiple health behaviours that co-occur in real life may reveal important insights into...

    Authors: Pauline Hautekiet, Nelly D. Saenen, Dries S. Martens, Margot Debay, Johan Van der Heyden, Tim S. Nawrot and Eva M. De Clercq
    Citation: BMC Medicine 2022 20:328
  3. Identifying pregnancies at risk for preterm birth, one of the leading causes of worldwide infant mortality, has the potential to improve prenatal care. However, we lack broadly applicable methods to accurately...

    Authors: Abin Abraham, Brian Le, Idit Kosti, Peter Straub, Digna R. Velez-Edwards, Lea K. Davis, J. M. Newton, Louis J. Muglia, Antonis Rokas, Cosmin A. Bejan, Marina Sirota and John A. Capra
    Citation: BMC Medicine 2022 20:333
  4. Tuberculosis remains the leading cause of death from a single infectious disease worldwide. Trials evaluating digital adherence technologies for tuberculosis in low- and middle-income countries are urgently ne...

    Authors: Tsegahun Manyazewal, Yimtubezinash Woldeamanuel, David P. Holland, Abebaw Fekadu and Vincent C. Marconi
    Citation: BMC Medicine 2022 20:310
  5. In vitro drug screening studies have indicated that camostat mesilate (FOY-305) may prevent SARS-CoV-2 infection into human airway epithelial cells. This study was conducted to investigate whether camostat mes...

    Authors: Taku Kinoshita, Masahiro Shinoda, Yasuhiro Nishizaki, Katsuya Shiraki, Yuji Hirai, Yoshiko Kichikawa, Kenji Tsushima, Masaharu Sinkai, Naoyuki Komura, Kazuo Yoshida, Yasutoshi Kido, Hiroshi Kakeya, Naoto Uemura and Junichi Kadota
    Citation: BMC Medicine 2022 20:342
  6. Age is the strongest risk factor for dementia and there is considerable interest in identifying scalable, blood-based biomarkers in predicting dementia. We examined the role of midlife serum metabolites using ...

    Authors: Marcos D. Machado-Fragua, Benjamin Landré, Mathilde Chen, Aurore Fayosse, Aline Dugravot, Mika Kivimaki, Séverine Sabia and Archana Singh-Manoux
    Citation: BMC Medicine 2022 20:334
  7. In the context of the COVID-19 pandemic, randomized controlled trials (RCTs) are essential to support clinical decision-making. We aimed (1) to assess and compare the reporting characteristics of RCTs between ...

    Authors: Philipp Kapp, Laura Esmail, Lina Ghosn, Philippe Ravaud and Isabelle Boutron
    Citation: BMC Medicine 2022 20:363
  8. Capecitabine maintenance therapy is safe and efficacious for early-stage triple-negative breast cancer (TNBC) patients, but the cost-effectiveness of its long-term use has not been investigated. Here, we evalu...

    Authors: Ji-Bin Li, Zhuo-Chen Lin, Martin C. S. Wong, Harry H. X. Wang, Mengmeng Li and Su Li
    Citation: BMC Medicine 2022 20:320
  9. Delirium is common after hip fracture surgery, affecting up to 50% of patients. The incidence of delirium may be influenced by mode and conduct of anaesthesia. We examined the effect of spinal anaesthesia (wit...

    Authors: Gulraj S. Matharu, Anjali Shah, Samuel Hawley, Antony Johansen, Dominic Inman, Iain Moppett, Michael R. Whitehouse and Andrew Judge
    Citation: BMC Medicine 2022 20:319
  10. Offspring born to women with pregestational type 1 diabetes (T1DM) are exposed to an intrauterine hyperglycemic milieu and has an increased risk of metabolic disease later in life. In this present study, we hy...

    Authors: Sine Knorr, Anne Skakkebæk, Jesper Just, Emma B. Johannsen, Christian Trolle, Søren Vang, Zuzana Lohse, Birgitte Bytoft, Peter Damm, Kurt Højlund, Dorte M. Jensen and Claus H. Gravholt
    Citation: BMC Medicine 2022 20:338
  11. The type 2 diabetes risk after gestational diabetes mellitus (GDM) is twice as high in South Asian compared to European women. Current guidelines differ regarding which test to use as a screening-tool post-GDM...

    Authors: Archana Sharma, Ingrid Nermoen, Elisabeth Qvigstad, Anh T. Tran, Christine Sommer, Naveed Sattar, Jason M. R. Gill, Hanne L. Gulseth, Stina T. Sollid and Kåre I. Birkeland
    Citation: BMC Medicine 2022 20:318
  12. Home-based palliative care (HPC) is considered to moderate the problem of rising healthcare utilization of cancer patients at end-of-life. Reports however suggest a proportion of HPC patients continue to exper...

    Authors: Qingyuan Zhuang, Poh-Heng Chong, Whee Sze Ong, Zhi Zheng Yeo, Cherylyn Qun Zhen Foo, Su Yan Yap, Guozhang Lee, Grace Meijuan Yang and Sungwon Yoon
    Citation: BMC Medicine 2022 20:313
  13. Most tobacco users initiate smoking during adolescence. Little is known about the global prevalence and trends in early cigarette smoking among adolescents. This study aimed to evaluate the prevalence of early...

    Authors: Huaqing Liu, Qi Qi, Ying Duan, Chuanwei Ma and Chengchao Zhou
    Citation: BMC Medicine 2022 20:311
  14. Employment disruptions can impact smoking and alcohol consumption. During the COVID-19 pandemic, many countries implemented furlough schemes to prevent job loss. We examine how furlough was associated with smo...

    Authors: Michael J. Green, Jane Maddock, Giorgio Di Gessa, Bożena Wielgoszewska, Sam Parsons, Gareth J. Griffith, Jazz Croft, Anna J. Stevenson, Charlotte F. Huggins, Charlotte Booth, Jacques Wels, Richard J. Silverwood, Praveetha Patalay, Alun D. Hughes, Nishi Chaturvedi, Laura D. Howe…
    Citation: BMC Medicine 2022 20:345
  15. The relationship between vitamin D status and mortality in patients with osteoarthritis (OA) is unknown. This study investigated the associations of serum 25-hydroxyvitamin D [25(OH)D] concentrations with all-...

    Authors: Qingqing Xiao, Bin Cai, Anwen Yin, Huanhuan Huo, Keke Lan, Guo Zhou, Linghong Shen and Ben He
    Citation: BMC Medicine 2022 20:308
  16. The results of a randomised trial showed the safety and efficacy of Gam-COVID-Vac against COVID-19. However, compared to other vaccines used across the globe, the real-world data on the effectiveness of Gam-CO...

    Authors: Anton Barchuk, Mikhail Cherkashin, Anna Bulina, Natalia Berezina, Tatyana Rakova, Darya Kuplevatskaya, Oksana Stanevich, Dmitriy Skougarevskiy and Artemiy Okhotin
    Citation: BMC Medicine 2022 20:312
  17. Non-communicable diseases (NCDs) are a leading cause of maternal mortality and morbidity worldwide. The World Health Organization is developing new recommendations focusing on the management of NCDs for pregna...

    Authors: Jenny Jung, Eshreena K. Karwal, Steve McDonald, Tari Turner, Doris Chou and Joshua P. Vogel
    Citation: BMC Medicine 2022 20:305
  18. Obesity is a well-established risk factor for atrial fibrillation (AF). Whether body fat depots differentially associate with AF development remains unknown.

    Authors: Zuolin Lu, Martijn J. Tilly, Elif Aribas, Daniel Bos, Sven Geurts, Bruno H. Stricker, Robert de Knegt, M. Arfan Ikram, Natasja M. S. de Groot, Trudy Voortman and Maryam Kavousi
    Citation: BMC Medicine 2022 20:317
  19. Although observational studies have reported associations between serum C-reactive protein (CRP) concentration and risks of lung, breast, and colorectal cancer, inconsistent or absent evidences were showed for...

    Authors: Meng Zhu, Zhimin Ma, Xu Zhang, Dong Hang, Rong Yin, Jifeng Feng, Lin Xu and Hongbing Shen
    Citation: BMC Medicine 2022 20:301
  20. In 2012, the World Health Organization (WHO) recommended single low-dose (SLD, 0.25 mg/kg) primaquine to be added as a Plasmodium (P.) falciparum gametocytocide to artemisinin-based combination therapy (ACT) with...

    Authors: Kasia Stepniewska, Elizabeth N. Allen, Georgina S. Humphreys, Eugenie Poirot, Elaine Craig, Kalynn Kennon, Daniel Yilma, Teun Bousema, Philippe J. Guerin, Nicholas J. White, Ric N. Price, Jaishree Raman, Andreas Martensson, Richard O. Mwaiswelo, Germana Bancone, Guido J. H. Bastiaens…
    Citation: BMC Medicine 2022 20:350
  21. Heterogeneity of the population in relation to infection, COVID-19 vaccination, and host characteristics is likely reflected in the underlying SARS-CoV-2 antibody responses.

    Authors: Marianna Karachaliou, Gemma Moncunill, Ana Espinosa, Gemma Castaño-Vinyals, Rocío Rubio, Marta Vidal, Alfons Jiménez, Esther Prados, Anna Carreras, Beatriz Cortés, Natàlia Blay, Marc Bañuls, Vanessa Pleguezuelos, Natalia Rodrigo Melero, Pau Serra, Daniel Parras…
    Citation: BMC Medicine 2022 20:347
  22. Lack of representativeness in Black, Indigenous, and People of Colour (BIPOC) enrollment could compromise the generalizability of study results and health equity. This study aimed to examine trends in BIPOC gr...

    Authors: Jingyi Zhang, Harriette G. C. Van Spall, Yaoyao Wang, Lehana Thabane, Ruoting Wang and Guowei Li
    Citation: BMC Medicine 2022 20:294
  23. Endometriosis is a common, complex disorder which is underrecognized and subject to prolonged delays in diagnosis. It is accompanied by significant changes in the eutopic endometrial lining.

    Authors: Andrew J. Shih, Robert P. Adelson, Himanshu Vashistha, Houman Khalili, Ashima Nayyar, Radha Puran, Rixsi Herrera, Prodyot K. Chatterjee, Annette T. Lee, Alexander M. Truskinovsky, Kristine Elmaliki, Margaret DeFranco, Christine N. Metz and Peter K. Gregersen
    Citation: BMC Medicine 2022 20:315
  24. Gestational diabetes (GDM) is prevalent and benefits from timely and effective treatment, given the short window to impact glycemic control. Clinicians face major barriers to choosing effectively among treatme...

    Authors: Lauren D. Liao, Assiamira Ferrara, Mara B. Greenberg, Amanda L. Ngo, Juanran Feng, Zhenhua Zhang, Patrick T. Bradshaw, Alan E. Hubbard and Yeyi Zhu
    Citation: BMC Medicine 2022 20:307
  25. The coronavirus disease (COVID-19) pandemic may have had significant mental health consequences for military personnel, which is a population already exposed to psychological stress. To assess the potential im...

    Authors: Marc-Antoine Sanchez, Basile Fuchs, Pascale Tubert-Bitter, Anne-Sophie Mariet, Fabrice Jollant, Aurélie Mayet and Catherine Quantin
    Citation: BMC Medicine 2022 20:306
  26. Zika virus (ZIKV), first discovered in Uganda in 1947, re-emerged globally in 2013 and was later associated with microcephaly and other birth defects. We determined the incidence of ZIKV infection and its asso...

    Authors: Eric Osoro, Irene Inwani, Cyrus Mugo, Elizabeth Hunsperger, Jennifer R. Verani, Victor Omballa, Dalton Wamalwa, Chulwoo Rhee, Ruth Nduati, John Kinuthia, Hafsa Jin, Lydia Okutoyi, Dufton Mwaengo, Brian Maugo, Nancy A. Otieno, Harriet Mirieri…
    Citation: BMC Medicine 2022 20:291
  27. Preeclampsia (PE) is a multisystemic maternal syndrome with substantial maternal and fetal morbidity and mortality. Currently, there is no clinically viable non-invasive biomarker assay for early detection, th...

    Authors: Siqi Bao, Tong Zhou, Congcong Yan, Jiale Bao, Fan Yang, Shan Chao, Meng Zhou and Zhangye Xu
    Citation: BMC Medicine 2022 20:303
  28. There has been a renewed interest in the role of dietary therapies to manage irritable bowel syndrome (IBS), with diet high on the agenda for patients. Currently, interest has focussed on the use of traditiona...

    Authors: A. Rej, A. Avery, I. Aziz, C. J. Black, R. K. Bowyer, R. L. Buckle, L. Seamark, C. C. Shaw, J. Thompson, N. Trott, M. Williams and D. S. Sanders
    Citation: BMC Medicine 2022 20:287
  29. Knee osteoarthritis is the most prevalent chronic musculoskeletal debilitating disease. Current treatments are only symptomatic, and to improve this, we need a robust prediction model to stratify patients at a...

    Authors: Hossein Bonakdari, Jean-Pierre Pelletier, Francisco J. Blanco, Ignacio Rego-Pérez, Alejandro Durán-Sotuela, Dawn Aitken, Graeme Jones, Flavia Cicuttini, Afshin Jamshidi, François Abram and Johanne Martel-Pelletier
    Citation: BMC Medicine 2022 20:316
  30. Observational studies have reported maternal short/long sleep duration to be associated with adverse pregnancy and perinatal outcomes. However, it remains unclear whether there are nonlinear causal effects. Ou...

    Authors: Qian Yang, Maria C. Magnus, Fanny Kilpi, Gillian Santorelli, Ana Gonçalves Soares, Jane West, Per Magnus, John Wright, Siri Eldevik Håberg, Eleanor Sanderson, Deborah A. Lawlor, Kate Tilling and Maria Carolina Borges
    Citation: BMC Medicine 2022 20:295
  31. Grip strength is a widely used and well-validated measure of overall health that is increasingly understood to index risk for psychiatric illness and neurodegeneration in older adults. However, existing work h...

    Authors: Rongtao Jiang, Margaret L. Westwater, Stephanie Noble, Matthew Rosenblatt, Wei Dai, Shile Qi, Jing Sui, Vince D. Calhoun and Dustin Scheinost
    Citation: BMC Medicine 2022 20:286
  32. High-grade serous carcinoma (HGSC) is the most frequent and lethal type of ovarian cancer. It has been proposed that tubal secretory cells are the origin of ovarian HGSC in women with familial BRCA1/2 mutations. ...

    Authors: Xuexin Yu, Wanrun Lin, Alexandra Spirtos, Yan Wang, Hao Chen, Jianfeng Ye, Jessica Parker, Ci Ci Liu, Yiying Wang, Gabriella Quinn, Feng Zhou, Setsuko K. Chambers, Cheryl Lewis, Jayanthi Lea, Bo Li and Wenxin Zheng
    Citation: BMC Medicine 2022 20:283
  33. Multimorbidity poses a major challenge for care coordination. However, data on what non-communicable diseases lead to multimorbidity, and whether the lifetime risk differs between men and women are lacking. We...

    Authors: Premysl Velek, Annemarie I. Luik, Guy G. O. Brusselle, Bruno Ch. Stricker, Patrick J. E. Bindels, Maryam Kavousi, Brenda C. T. Kieboom, Trudy Voortman, Rikje Ruiter, M. Arfan Ikram, M. Kamran Ikram, Evelien I. T. de Schepper and Silvan Licher
    Citation: BMC Medicine 2022 20:304
  34. In China, colorectal cancer (CRC) incidence and mortality have been steadily increasing over the last decades. Risk models to predict incident CRC have been developed in various populations, but they have not ...

    Authors: Roxanna E. Abhari, Blake Thomson, Ling Yang, Iona Millwood, Yu Guo, Xiaoming Yang, Jun Lv, Daniel Avery, Pei Pei, Peng Wen, Canqing Yu, Yiping Chen, Junshi Chen, Liming Li, Zhengming Chen and Christiana Kartsonaki
    Citation: BMC Medicine 2022 20:302
  35. Recent studies have reported improved diastolic function in patients administered sodium-glucose cotransporter 2 inhibitors (SGLT2i). We aimed to investigate the effect of dapagliflozin on left ventricular (LV...

    Authors: Seul-Gee Lee, Darae Kim, Jung-Jae Lee, Hyun-Ju Lee, Ro-kyung Moon, Yong-Joon Lee, Seung-Jun Lee, Oh-Hyun Lee, Choongki Kim, Jaewon Oh, Chan Joo Lee, Yong-ho Lee, Seil Park, Ok-Hee Jeon, Donghoon Choi, Geu-Ru Hong…
    Citation: BMC Medicine 2022 20:309
  36. Onchocerciasis is a disease caused by infection with Onchocerca volvulus, which is transmitted to humans via the bite of several species of black fly, and is responsible for permanent blindness or vision loss, as...

    Authors: Chris A. Schmidt, Elizabeth A. Cromwell, Elex Hill, Katie M. Donkers, Megan F. Schipp, Kimberly B. Johnson, David M. Pigott and Simon I. Hay
    Citation: BMC Medicine 2022 20:293
  37. Studies on physical activity (PA) and mental health are largely limited to self-reported PA. This study aims to use prospective cohort data to investigate the association between device-measured PA and affecti...

    Authors: Frederick K. Ho, Fanny Petermann-Rocha, Solange Parra-Soto, Jirapitcha Boonpor, Jason M. R. Gill, Stuart R. Gray, Jill P. Pell and Carlos Celis-Morales
    Citation: BMC Medicine 2022 20:290
  38. Beta-blocker (BB) and calcium channel blocker (CCB) antihypertensive drugs are commonly used in pregnancy. However, data on their relative impact on maternal and foetal outcomes are limited. We leveraged genet...

    Authors: Maddalena Ardissino, Eric A. W. Slob, Skanda Rajasundaram, Rohin K. Reddy, Benjamin Woolf, Joanna Girling, Mark R. Johnson, Fu Siong Ng and Dipender Gill
    Citation: BMC Medicine 2022 20:288
  39. How much scientific evidence is there to show that stem cell therapy is sufficient in preclinical and clinical studies of spinal cord injury before it is translated into clinical practice? This is a complicate...

    Authors: Zhizhong Shang, Mingchuan Wang, Baolin Zhang, Xin Wang and Pingping Wanyan
    Citation: BMC Medicine 2022 20:284
  40. Some occult hepatitis B virus (HBV) infections are resulted from PreS mutations that reduce secretion of envelope protein (HBsAg). We investigated the ceramide amounts and species in hepatocytes infected with ...

    Authors: Chang Liu, Kun Chen, Fei Zhao, Lingling Xuan, Yuting Wang, Chungui Xu, Zhiyuan Wu, Dongmei Wang and Chunfeng Qu
    Citation: BMC Medicine 2022 20:279
  41. Clinical complexity is increasingly prevalent among patients with atrial fibrillation (AF). The ‘Atrial fibrillation Better Care’ (ABC) pathway approach has been proposed to streamline a more holistic and inte...

    Authors: Giulio Francesco Romiti, Marco Proietti, Marco Vitolo, Niccolò Bonini, Ameenathul Mazaya Fawzy, Wern Yew Ding, Laurent Fauchier, Francisco Marin, Michael Nabauer, Gheorghe Andrei Dan, Tatjana S. Potpara, Giuseppe Boriani and Gregory Y. H. Lip
    Citation: BMC Medicine 2022 20:326
  42. Adolescent obesity has been reported to have deleterious consequences but is considered a promising modifiable risk factor. We aimed to investigate the optimal intervention for obese and overweight children an...

    Authors: Jing Hong Liang, Yu Zhao, Yi Can Chen, Nan Jiang, Shu Xin Zhang, Shan Huang, Aerziguli Kakaer and Ya Jun Chen
    Citation: BMC Medicine 2022 20:325
  43. Acute kidney injury (AKI) is frequently associated with COVID-19, and the need for kidney replacement therapy (KRT) is considered an indicator of disease severity. This study aimed to develop a prognostic scor...

    Authors: Flávio de Azevedo Figueiredo, Lucas Emanuel Ferreira Ramos, Rafael Tavares Silva, Daniela Ponce, Rafael Lima Rodrigues de Carvalho, Alexandre Vargas Schwarzbold, Amanda de Oliveira Maurílio, Ana Luiza Bahia Alves Scotton, Andresa Fontoura Garbini, Bárbara Lopes Farace, Bárbara Machado Garcia, Carla Thais Cândida Alves da Silva, Christiane Corrêa Rodrigues Cimini, Cíntia Alcantara de Carvalho, Cristiane dos Santos Dias, Daniel Vitório Silveira…
    Citation: BMC Medicine 2022 20:324
  44. Use of kinase inhibitors such as dasatinib and imatinib might increase the risk of opportunistic infections, especially Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infections. However, the effect of sor...

    Authors: Xin Xu, Zhiping Fan, Yu Wang, Fen Huang, Yajing Xu, Jing Sun, Na Xu, Lan Deng, Xudong Li, Xinquan Liang, Xiaodan Luo, Pengcheng Shi, Hui Liu, Yan Chen, Sanfang Tu, Xiaojun Huang…
    Citation: BMC Medicine 2022 20:282
  45. COVID-19 vaccines have been crucial in the pandemic response and understanding changes in vaccines effectiveness is essential to guide vaccine policies. Although the Delta variant is no longer dominant, unders...

    Authors: Jostein Starrfelt, Anders Skyrud Danielsen, Eirik Alnes Buanes, Lene Kristine Juvet, Trude Marie Lyngstad, Gunnar Øyvind Isaksson Rø, Lamprini Veneti, Sara Viksmoen Watle and Hinta Meijerink
    Citation: BMC Medicine 2022 20:278
  46. To examine the association between regular use of proton pump inhibitors and the risk of incident dementia, including dementia subtypes, and whether the association differs between APOE genotypes.

    Authors: Peidong Zhang, Zhihao Li, Peiliang Chen, Ao Zhang, Yu Zeng, Xiru Zhang, Qingmei Huang, Dan Liu, Songtao Qi and Chen Mao
    Citation: BMC Medicine 2022 20:271
  47. Tackling problematic polypharmacy requires tailoring the use of medicines to individual circumstances and may involve the process of deprescribing. Deprescribing can cause anxiety and concern for clinicians an...

    Authors: Amadea Turk, Geoffrey Wong, Kamal R. Mahtani, Michelle Madden, Ruaraidh Hill, Ed Ranson, Emma Wallace, Janet Krska, Dee Mangin, Richard Byng, Daniel Lasserson and Joanne Reeve
    Citation: BMC Medicine 2022 20:297