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  1. In order to improve malaria burden estimates in low transmission settings, more sensitive tools and efficient sampling strategies are required. This study evaluated the use of serological measures from repeate...

    Authors: Henry Surendra, Supargiyono, Riris A. Ahmad, Rizqiani A. Kusumasari, Theodola B. Rahayujati, Siska Y. Damayanti, Kevin K. A. Tetteh, Chetan Chitnis, Gillian Stresman, Jackie Cook and Chris Drakeley

    Citation: BMC Medicine 2020 18:9

    Content type: Research article

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  2. An update of the chapter on Mental, Behavioral and Neurodevelopmental Disorders in the International Classification of Diseases and Related Health Problems (ICD) is of great interest around the world. The rece...

    Authors: Dan J. Stein, Peter Szatmari, Wolfgang Gaebel, Michael Berk, Eduard Vieta, Mario Maj, Ymkje Anna de Vries, Annelieke M. Roest, Peter de Jonge, Andreas Maercker, Chris R. Brewin, Kathleen M. Pike, Carlos M. Grilo, Naomi A. Fineberg, Peer Briken, Peggy T. Cohen-Kettenis…

    Citation: BMC Medicine 2020 18:21

    Content type: Forum

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    The Commentary to this article has been published in BMC Medicine 2020 18:25

  3. The original article [1] contains an omitted grant acknowledgement and affiliation as relates to the contribution of co-author, Rafael Perera-Salazar. As such, the following two amendments should apply to the ...

    Authors: Magdalena Nowakowska, Salwa S. Zghebi, Darren M. Ashcroft, Iain Buchan, Carolyn Chew-Graham, Tim Holt, Christian Mallen, Harm Van Marwijk, Niels Peek, Rafael Perera-Salazar, David Reeves, Martin K. Rutter, Stephen F. Weng, Nadeem Qureshi, Mamas A. Mamas and Evangelos Kontopantelis

    Citation: BMC Medicine 2020 18:22

    Content type: Correction

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    The original article was published in BMC Medicine 2019 17:145

  4. Dystroglycanopathies are a group of inherited disorders characterized by vast clinical and genetic heterogeneity and caused by abnormal functioning of the ECM receptor dystroglycan (Dg). Remarkably, among many...

    Authors: Andriy S. Yatsenko, Mariya M. Kucherenko, Yuanbin Xie, Dina Aweida, Henning Urlaub, Renate J. Scheibe, Shenhav Cohen and Halyna R. Shcherbata

    Citation: BMC Medicine 2020 18:8

    Content type: Research article

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  5. Participation in randomized controlled trials (RCTs) may be quite demanding and could represent an important burden for patients. We aimed to explore this research burden (i.e., the psychological, physical, an...

    Authors: Nivantha Naidoo, Van Thu Nguyen, Philippe Ravaud, Bridget Young, Philippe Amiel, Daniel Schanté, Mike Clarke and Isabelle Boutron

    Citation: BMC Medicine 2020 18:6

    Content type: Research article

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  6. Inflammation contributes to the pathophysiology of major depressive disorder (MDD), and anti-inflammatory strategies might therefore have therapeutic potential. This trial aimed to determine whether adjunctive...

    Authors: Michael Berk, Mohammadreza Mohebbi, Olivia M. Dean, Sue M. Cotton, Andrew M. Chanen, Seetal Dodd, Aswin Ratheesh, G. Paul Amminger, Mark Phelan, Amber Weller, Andrew Mackinnon, Francesco Giorlando, Shelley Baird, Lisa Incerti, Rachel E. Brodie, Natalie O. Ferguson…

    Citation: BMC Medicine 2020 18:16

    Content type: Research article

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  7. In endemic areas, pregnant women are highly susceptible to Plasmodium falciparum malaria characterized by the accumulation of parasitized red blood cells (pRBC) in the placenta. In subsequent pregnancies, women d...

    Authors: Julia C. Cutts, Paul A. Agius, Zaw Lin, Rosanna Powell, Kerryn Moore, Bridget Draper, Julie A. Simpson and Freya J. I. Fowkes

    Citation: BMC Medicine 2020 18:14

    Content type: Research article

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  8. The present study aims to assess the cost-effectiveness of an influenza vaccination program for children in the Netherlands. This requires an evaluation of the long-term impact of such a program on the burden ...

    Authors: Pieter T. de Boer, Jantien A. Backer, Albert Jan van Hoek and Jacco Wallinga

    Citation: BMC Medicine 2020 18:11

    Content type: Research article

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  9. The consumption of free sugars in the UK is more than double the guideline intake for adults and close to triple for children, with soft drinks representing a significant proportion. The aim of this study was ...

    Authors: L. K. Bandy, P. Scarborough, R. A. Harrington, M. Rayner and S. A. Jebb

    Citation: BMC Medicine 2020 18:20

    Content type: Research article

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  10. Although lifestyle factors have been studied in relation to individual non-communicable diseases (NCDs), their association with development of a subsequent NCD, defined as multimorbidity, has been scarcely inv...

    Authors: Heinz Freisling, Vivian Viallon, Hannah Lennon, Vincenzo Bagnardi, Cristian Ricci, Adam S. Butterworth, Michael Sweeting, David Muller, Isabelle Romieu, Pauline Bazelle, Marina Kvaskoff, Patrick Arveux, Gianluca Severi, Christina Bamia, Tilman Kühn, Rudolf Kaaks…

    Citation: BMC Medicine 2020 18:5

    Content type: Research article

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  11. Promoting breastfeeding is an important public health intervention, with benefits for infants and mothers. Even modest increases in prevalence and duration may yield considerable economic savings. However, des...

    Authors: Mary S. Fewtrell, Nurul H. Mohd Shukri and Jonathan C. K. Wells

    Citation: BMC Medicine 2020 18:4

    Content type: Opinion

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  12. Endometriosis is a gynaecological condition characterised by immune cell infiltration and distinct inflammatory signatures found in the peritoneal cavity. In this study, we aim to characterise the immune micro...

    Authors: Manman Guo, Cemsel Bafligil, Thomas Tapmeier, Carol Hubbard, Sanjiv Manek, Catherine Shang, Fernando O. Martinez, Nicole Schmidt, Maik Obendorf, Holger Hess-Stumpp, Thomas M. Zollner, Stephen Kennedy, Christian M. Becker, Krina T. Zondervan, Adam P. Cribbs and Udo Oppermann

    Citation: BMC Medicine 2020 18:3

    Content type: Research article

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  13. Heart failure (HF) has been recognized as a global pandemic with a high rate of hospitalization, morbidity, and mortality. Although numerous advances have been made, its representative molecular signatures rem...

    Authors: Xiumeng Hua, Yin-Ying Wang, Peilin Jia, Qing Xiong, Yiqing Hu, Yuan Chang, Songqing Lai, Yong Xu, Zhongming Zhao and Jiangping Song

    Citation: BMC Medicine 2020 18:2

    Content type: Research article

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  14. Antimicrobial resistance (AMR) is an increasing threat to global health. There are > 14 million cases of enteric fever every year and > 135,000 deaths. The disease is primarily controlled by antimicrobial trea...

    Authors: Annie J. Browne, Bahar H. Kashef Hamadani, Emmanuelle A. P. Kumaran, Puja Rao, Joshua Longbottom, Eli Harriss, Catrin E. Moore, Susanna Dunachie, Buddha Basnyat, Stephen Baker, Alan D. Lopez, Nicholas P. J. Day, Simon I. Hay and Christiane Dolecek

    Citation: BMC Medicine 2020 18:1

    Content type: Research article

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  15. Evaluation of health technology programmes should be theoretically informed, interdisciplinary, and generate in-depth explanations. The NASSS (non-adoption, abandonment, scale-up, spread, sustainability) frame...

    Authors: Seye Abimbola, Bindu Patel, David Peiris, Anushka Patel, Mark Harris, Tim Usherwood and Trisha Greenhalgh

    Citation: BMC Medicine 2019 17:233

    Content type: Research article

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  16. Repeated outbreaks of emerging pathogens underscore the need for preparedness plans to prevent, detect, and respond. As countries develop and improve National Action Plans for Health Security, addressing subna...

    Authors: E. N. Hulland, K. E. Wiens, S. Shirude, J. D. Morgan, A. Bertozzi-Villa, T. H. Farag, N. Fullman, M. U. G. Kraemer, M. K. Miller-Petrie, V. Gupta, R. C. Reiner Jr., P. Rabinowitz, J. N. Wasserheit, B. P. Bell, S. I. Hay, D. J. Weiss…

    Citation: BMC Medicine 2019 17:232

    Content type: Research article

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  17. There are an estimated 800,000 suicides per year globally, and approximately 16,000,000 suicide attempts. Mobile apps may help address the unmet needs of people at risk. We assessed adherence of suicide preven...

    Authors: Laura Martinengo, Louise Van Galen, Elaine Lum, Martin Kowalski, Mythily Subramaniam and Josip Car

    Citation: BMC Medicine 2019 17:231

    Content type: Research article

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  18. The assessment of calibration performance of risk prediction models based on regression or more flexible machine learning algorithms receives little attention.

    Authors: Ben Van Calster, David J. McLernon, Maarten van Smeden, Laure Wynants and Ewout W. Steyerberg

    Citation: BMC Medicine 2019 17:230

    Content type: Opinion

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  19. Delirium is a common severe neuropsychiatric condition secondary to physical illness, which predominantly affects older adults in hospital. Prior to this study, the UK point prevalence of delirium was unknown....

    Authors:

    Citation: BMC Medicine 2019 17:229

    Content type: Research article

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  20. In January 2017, the Dutch cervical cancer screening programme transitioned from cytomorphological to primary high-risk HPV (hrHPV) DNA screening, including the introduction of self-sampling, for women aged be...

    Authors: Clare A. Aitken, Heleen M. E. van Agt, Albert G. Siebers, Folkert J. van Kemenade, Hubert G. M. Niesters, Willem J. G. Melchers, Judith E. M. Vedder, Rob Schuurman, Adriaan J. C. van den Brule, Hans C. van der Linden, John W. J. Hinrichs, Anco Molijn, Klaas J. Hoogduin, Bettien M. van Hemel and Inge M. C. M. de Kok

    Citation: BMC Medicine 2019 17:228

    Content type: Research article

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  21. Proprotein convertase subtilisin/kexin 9 (PCSK9) is an important regulator of low-density lipoprotein receptor (LDLR) and plasma levels of LDL cholesterol (LDL-C). PCSK9 inhibition is an efficient therapeutic ...

    Authors: Amir Abbas Momtazi-Borojeni, Mahmoud Reza Jaafari, Ali Badiee, Maciej Banach and Amirhossein Sahebkar

    Citation: BMC Medicine 2019 17:223

    Content type: Research article

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  22. As malaria transmission declines, understanding the differential impact of intensified control on Plasmodium falciparum relative to Plasmodium vivax and identifying key drivers of ongoing transmission is essentia...

    Authors: Maria Ome-Kaius, Johanna Helena Kattenberg, Sophie Zaloumis, Matthew Siba, Benson Kiniboro, Shadrach Jally, Zahra Razook, Daisy Mantila, Desmond Sui, Jason Ginny, Anna Rosanas-Urgell, Stephan Karl, Thomas Obadia, Alyssa Barry, Stephen J. Rogerson, Moses Laman…

    Citation: BMC Medicine 2019 17:220

    Content type: Research article

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  23. Variable and poor care quality are important causes of preventable patient harm. Many patients receive less than recommended care, but the extent of the problem remains largely unknown. The CareTrack Kids (CTK...

    Authors: Louise K. Wiles, Carl de Wet, Chris Dalton, Elisabeth Murphy, Mark F. Harris, Peter D. Hibbert, Charlotte J. Molloy, Gaston Arnolda, Hsuen P. Ting and Jeffrey Braithwaite

    Citation: BMC Medicine 2019 17:218

    Content type: Research article

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  24. In November 2011, Malawi introduced the 13-valent pneumococcal conjugate vaccine (PCV13) into the routine infant schedule. Four to 7 years after introduction (2015–2018), rolling prospective nasopharyngeal car...

    Authors: J. Lourenço, U. Obolski, T. D. Swarthout, A. Gori, N. Bar-Zeev, D. Everett, A. W. Kamng’ona, T. S. Mwalukomo, A. A. Mataya, C. Mwansambo, M. Banda, S. Gupta, N. French and R. S. Heyderman

    Citation: BMC Medicine 2019 17:219

    Content type: Research article

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  25. The nature of symptoms in the prodromal period of first episode psychosis (FEP) remains unclear. The objective was to determine the patterns of symptoms recorded in primary care in the 5 years before FEP diagn...

    Authors: Ying Chen, Saeed Farooq, John Edwards, Carolyn A. Chew-Graham, David Shiers, Martin Frisher, Richard Hayward, Athula Sumathipala and Kelvin P. Jordan

    Citation: BMC Medicine 2019 17:227

    Content type: Research article

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  26. Associations between type 2 diabetes (T2D) and amyotrophic lateral sclerosis (ALS) were discovered in observational studies in both European and East Asian populations. However, whether such associations are c...

    Authors: Ping Zeng, Ting Wang, Junnian Zheng and Xiang Zhou

    Citation: BMC Medicine 2019 17:225

    Content type: Research article

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  27. Even though in situ breast cancer (BCIS) accounts for a large proportion of the breast cancers diagnosed, few studies have investigated potential risk factors for BCIS. Their results suggest that some establis...

    Authors: Nena Karavasiloglou, Anika Hüsing, Giovanna Masala, Carla H. van Gils, Renée Turzanski Fortner, Jenny Chang-Claude, Inge Huybrechts, Elisabete Weiderpass, Marc Gunter, Patrick Arveux, Agnès Fournier, Marina Kvaskoff, Anne Tjønneland, Cecilie Kyrø, Christina C. Dahm, Helene Tilma Vistisen…

    Citation: BMC Medicine 2019 17:221

    Content type: Research article

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  28. Excess weight and unexpected weight loss are associated with multiple disease states and increased morbidity and mortality, but weight measurement is not routine in many primary care settings. The aim of this ...

    Authors: B. D. Nicholson, P. Aveyard, C. R. Bankhead, W. Hamilton, F. D. R. Hobbs and S. Lay-Flurrie

    Citation: BMC Medicine 2019 17:222

    Content type: Research article

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  29. Insulin resistance (IR) is predictive for type 2 diabetes and associated with various metabolic abnormalities in fasting conditions. However, limited data are available on how IR affects metabolic responses in...

    Authors: Qin Wang, Jari Jokelainen, Juha Auvinen, Katri Puukka, Sirkka Keinänen-Kiukaanniemi, Marjo-Riitta Järvelin, Johannes Kettunen, Ville-Petteri Mäkinen and Mika Ala-Korpela

    Citation: BMC Medicine 2019 17:217

    Content type: Research article

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  30. Low-dose mercury (Hg) exposure has been associated with cardiovascular diseases, diabetes, and obesity in adults, but it is unknown the metabolic consequence of in utero Hg exposure. This study aimed to invest...

    Authors: Guoying Wang, Jessica DiBari, Eric Bind, Andrew M. Steffens, Jhindan Mukherjee, Tami R. Bartell, David C. Bellinger, Xiumei Hong, Yuelong Ji, Mei-Cheng Wang, Marsha Wills-Karp, Tina L. Cheng and Xiaobin Wang

    Citation: BMC Medicine 2019 17:216

    Content type: Research article

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  31. Although long-term alcohol and tobacco use have widely been recognised as important risk factors for cancer, the impacts of alcohol and tobacco health policies on cancer mortality have not been examined in pre...

    Authors: Heng Jiang, Michael Livingston, Robin Room, Yong Gan, Dallas English and Richard Chenhall

    Citation: BMC Medicine 2019 17:213

    Content type: Research article

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  32. Outcomes of processes questioning a physician’s ability to practise —e.g. disciplinary or regulatory— may strongly impact their career and provided care. However, it is unclear what factors relate systematical...

    Authors: Javier A. Caballero and Steve P. Brown

    Citation: BMC Medicine 2019 17:211

    Content type: Research Article

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  33. Moderate-to-severe diarrhea (MSD) in the first 2 years of life can impair linear growth. We sought to determine risk factors for linear growth faltering and to build a clinical prediction tool to identify chil...

    Authors: Rebecca L. Brander, Patricia B. Pavlinac, Judd L. Walson, Grace C. John-Stewart, Marcia R. Weaver, Abu S. G. Faruque, Anita K. M. Zaidi, Dipika Sur, Samba O. Sow, M. Jahangir Hossain, Pedro L. Alonso, Robert F. Breiman, Dilruba Nasrin, James P. Nataro, Myron M. Levine and Karen L. Kotloff

    Citation: BMC Medicine 2019 17:214

    Content type: Research article

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  34. In recent decades, the prevalence of obesity in children has increased dramatically. This worldwide epidemic has important consequences, including psychiatric, psychological and psychosocial disorders in child...

    Authors: Mariachiara Di Cesare, Maroje Sorić, Pascal Bovet, J Jaime Miranda, Zulfiqar Bhutta, Gretchen A Stevens, Avula Laxmaiah, Andre-Pascal Kengne and James Bentham

    Citation: BMC Medicine 2019 17:212

    Content type: Review

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  35. The term ‘double burden of malnutrition’ is usually interpreted in terms of the physical status of children: stunted and wasted children on the one hand and overweight/obese children on the other. There is a t...

    Authors: Martha Mwangome and Andrew M. Prentice

    Citation: BMC Medicine 2019 17:210

    Content type: Editorial

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  36. Stunting affects more than 161 million children worldwide and can compromise cognitive development beginning early in childhood. There is a paucity of research using neuroimaging tools in conjunction with sens...

    Authors: Wanze Xie, Sarah K. G. Jensen, Mark Wade, Swapna Kumar, Alissa Westerlund, Shahria H. Kakon, Rashidul Haque, William A. Petri and Charles A. Nelson

    Citation: BMC Medicine 2019 17:199

    Content type: Research article

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  37. Tuberculosis (TB) control efforts are hampered by an imperfect understanding of TB epidemiology. The true age distribution of disease is unknown because a large proportion of individuals with active TB remain ...

    Authors: Romain Ragonnet, James M. Trauer, Nicholas Geard, Nick Scott and Emma S. McBryde

    Citation: BMC Medicine 2019 17:208

    Content type: Research article

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  38. The 8th edition of the American Joint Committee on Cancer (AJCC) staging has introduced prognostic stage based on anatomic stage combined with biologic factors. We aimed to validate the prognostic stage in HER...

    Authors: Maria Vittoria Dieci, Giancarlo Bisagni, Alba A. Brandes, Antonio Frassoldati, Luigi Cavanna, Francesco Giotta, Michele Aieta, Vittorio Gebbia, Antonino Musolino, Ornella Garrone, Michela Donadio, Anita Rimanti, Alessandra Beano, Claudio Zamagni, Hector Soto Parra, Federico Piacentini…

    Citation: BMC Medicine 2019 17:207

    Content type: Research article

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  39. Clinical guidelines and public health authorities lack recommendations on scalable approaches to defining and monitoring the occurrence and severity of bleeding in populations prescribed antithrombotic therapy.

    Authors: Laura Pasea, Sheng-Chia Chung, Mar Pujades-Rodriguez, Anoop D. Shah, Samantha Alvarez-Madrazo, Victoria Allan, James T. Teo, Daniel Bean, Reecha Sofat, Richard Dobson, Amitava Banerjee, Riyaz S. Patel, Adam Timmis, Spiros Denaxas and Harry Hemingway

    Citation: BMC Medicine 2019 17:206

    Content type: Research article

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  40. The peer review process has been questioned as it may fail to allow the publication of high-quality articles. This study aimed to evaluate the accuracy in identifying inadequate reporting in RCT reports by ear...

    Authors: Anthony Chauvin, Philippe Ravaud, David Moher, David Schriger, Sally Hopewell, Daniel Shanahan, Sabina Alam, Gabriel Baron, Jean-Philippe Regnaux, Perrine Crequit, Valeria Martinez, Carolina Riveros, Laurence Le Cleach, Alessandro Recchioni, Douglas G. Altman and Isabelle Boutron

    Citation: BMC Medicine 2019 17:205

    Content type: Research article

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  41. Brain innate immunity is vital for maintaining normal brain functions. Immune homeostatic imbalances play pivotal roles in the pathogenesis of neurological diseases including Parkinson’s disease (PD). However,...

    Authors: Shu-zhen Zhang, Qin-qin Wang, Qiao-qiao Yang, Huan-yu Gu, Yan-qing Yin, Yan-dong Li, Jin-can Hou, Rong Chen, Qing-qing Sun, Ying-feng Sun, Gang Hu and Jia-wei Zhou

    Citation: BMC Medicine 2019 17:204

    Content type: Research article

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