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  1. Content type: Research article

    Adopting clinical genomics represents a major systems-level intervention requiring diverse expertise and collective learning. The Australian Genomic Health Alliance (Australian Genomics) is strategically linki...

    Authors: Janet C. Long, Chiara Pomare, Stephanie Best, Tiffany Boughtwood, Kathryn North, Louise A. Ellis, Kate Churruca and Jeffrey Braithwaite

    Citation: BMC Medicine 2019 17:44

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  2. Content type: Research article

    Sustainable Development Goals set a challenge for the elimination of hepatitis B virus (HBV) infection as a public health concern by the year 2030. Deployment of a robust prophylactic vaccine and enhanced inte...

    Authors: Anna L. McNaughton, José Lourenço, Louise Hattingh, Emily Adland, Samantha Daniels, Anriette Van Zyl, Connie S. Akiror, Susan Wareing, Katie Jeffery, M. Azim Ansari, Paul Klenerman, Philip J. R. Goulder, Sunetra Gupta, Pieter Jooste and Philippa C. Matthews

    Citation: BMC Medicine 2019 17:43

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  3. Content type: Research article

    Cathelicidins are a major group of natural antimicrobial peptides which play essential roles in regulating host defense and immunity. In addition to the antimicrobial and immunomodulatory activities, recent st...

    Authors: Yihua Bei, Li-Long Pan, Qiulian Zhou, Cuimei Zhao, Yuan Xie, Chengfei Wu, Xiangmin Meng, Huanyu Gu, Jiahong Xu, Lei Zhou, Joost P. G. Sluijter, Saumya Das, Birgitta Agerberth, Jia Sun and Junjie Xiao

    Citation: BMC Medicine 2019 17:42

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  4. Content type: Research article

    Recently, euthanasia and assisted suicide (EAS) in patients with psychiatric disorders, dementia, or an accumulation of health problems has taken a prominent place in the public debate. However, limited is kno...

    Authors: Kirsten Evenblij, H. Roeline W. Pasman, Agnes van der Heide, Trynke Hoekstra and Bregje D. Onwuteaka-Philipsen

    Citation: BMC Medicine 2019 17:39

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  5. Content type: Research article

    Thymic size in early infancy predicts subsequent survival in low-income settings. The human thymus develops from early gestation, is most active in early life and is highly sensitive to malnutrition. Our objec...

    Authors: Sophie E. Moore, Anthony J. C. Fulford, Fatou Sosseh, Patrick Nshe, Momodou K. Darboe and Andrew M. Prentice

    Citation: BMC Medicine 2019 17:38

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  6. Content type: Correction

    The original article [1] contained two minor errors.

    Authors: Michael Berk, Alyna Turner, Gin S. Malhi, Chee H. Ng, Susan M. Cotton, Seetal Dodd, Yuval Samuni, Michelle Tanious, Claire McAulay, Nathan Dowling, Jerome Sarris, Lauren Owen, Astrid Waterdrinker, Deidre Smith and Olivia M. Dean

    Citation: BMC Medicine 2019 17:35

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    The original article was published in BMC Medicine 2019 17:18

  7. Content type: Research article

    Researchers have long recognized that stigma is a global, multi-level phenomenon requiring intervention approaches that target multiple levels including individual, interpersonal, community, and structural lev...

    Authors: Deepa Rao, Ahmed Elshafei, Minh Nguyen, Mark L. Hatzenbuehler, Sarah Frey and Vivian F. Go

    Citation: BMC Medicine 2019 17:41

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  8. Content type: Correspondence

    Stigma is a well-documented barrier to health seeking behavior, engagement in care and adherence to treatment across a range of health conditions globally. In order to halt the stigmatization process and mitig...

    Authors: Anne L. Stangl, Valerie A. Earnshaw, Carmen H. Logie, Wim van Brakel, Leickness C. Simbayi, Iman Barré and John F. Dovidio

    Citation: BMC Medicine 2019 17:31

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  9. Content type: Correspondence

    Stigma in health facilities undermines diagnosis, treatment, and successful health outcomes. Addressing stigma is fundamental to delivering quality healthcare and achieving optimal health. This correspondence ...

    Authors: Laura Nyblade, Melissa A. Stockton, Kayla Giger, Virginia Bond, Maria L. Ekstrand, Roger Mc Lean, Ellen M. H. Mitchell, La Ron E. Nelson, Jaime C. Sapag, Taweesap Siraprapasiri, Janet Turan and Edwin Wouters

    Citation: BMC Medicine 2019 17:25

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  10. Content type: Research article

    Stigma is associated with health conditions that drive disease burden in low- and middle-income countries (LMICs), including HIV, tuberculosis, mental health problems, epilepsy, and substance use disorders. Ho...

    Authors: Jeremy C. Kane, Melissa A. Elafros, Sarah M. Murray, Ellen M. H. Mitchell, Jura L. Augustinavicius, Sara Causevic and Stefan D. Baral

    Citation: BMC Medicine 2019 17:17

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  11. Content type: Opinion

    Many health conditions perceived to be contagious, dangerous or incurable, or resulting in clearly visible signs, share a common attribute – an association with stigma and discrimination. While the etiology of...

    Authors: Wim H. van Brakel, Janine Cataldo, Sandeep Grover, Brandon A. Kohrt, Laura Nyblade, Melissa Stockton, Edwin Wouters and Lawrence H. Yang

    Citation: BMC Medicine 2019 17:13

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  12. Content type: Correspondence

    ‘Intersectional stigma’ is a concept that has emerged to characterize the convergence of multiple stigmatized identities within a person or group, and to address their joint effects on health and wellbeing. Wh...

    Authors: Janet M. Turan, Melissa A. Elafros, Carmen H. Logie, Swagata Banik, Bulent Turan, Kaylee B. Crockett, Bernice Pescosolido and Sarah M. Murray

    Citation: BMC Medicine 2019 17:7

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  13. Content type: Research article

    Interventions to alleviate stigma are demonstrating effectiveness across a range of conditions, though few move beyond the pilot phase, especially in low- and middle-income countries (LMICs). Implementation sc...

    Authors: Christopher G. Kemp, Brooke A. Jarrett, Churl-Su Kwon, Lanxin Song, Nathalie Jetté, Jaime C. Sapag, Judith Bass, Laura Murray, Deepa Rao and Stefan Baral

    Citation: BMC Medicine 2019 17:6

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  14. Content type: Research article

    High-throughput non-invasive prenatal testing (NIPT) for fetal Rhesus D (RhD) status could avoid unnecessary treatment with anti-D immunoglobulin for RhD-negative women found to be carrying an RhD-negative fet...

    Authors: Huiqin Yang, Alexis Llewellyn, Ruth Walker, Melissa Harden, Pedro Saramago, Susan Griffin and Mark Simmonds

    Citation: BMC Medicine 2019 17:37

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  15. Content type: Research article

    Financial risk protection (FRP) is a key objective of national health systems and a core pillar of universal health coverage (UHC). Yet, little is known about the disease-specific distribution of catastrophic ...

    Authors: Annie Haakenstad, Matthew Coates, Andrew Marx, Gene Bukhman and Stéphane Verguet

    Citation: BMC Medicine 2019 17:36

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  16. Content type: Research article

    In 2012, the UK introduced medical revalidation, whereby to retain their licence all doctors are required to show periodically that they are up to date and fit to practise medicine. Early reports suggested tha...

    Authors: Nils Gutacker, Karen Bloor, Chris Bojke, Julian Archer and Kieran Walshe

    Citation: BMC Medicine 2019 17:33

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  17. Content type: Research article

    Almost all countries without complete vital registration systems have data on deaths collected by hospitals. However, these data have not been widely used to estimate cause of death (COD) patterns in populatio...

    Authors: Gail M. Williams, Ian Douglas Riley, Riley H. Hazard, Hafizur R. Chowhury, Nurul Alam, Peter Kim Streafield, Veronica Tallo, Diozele Sanvictores, Marilla Lucero, Tim Adair and Alan D. Lopez

    Citation: BMC Medicine 2019 17:29

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  18. Content type: Research article

    The India Newborn Action Plan (INAP) aims for < 10 stillbirths per 1000 births by 2030. A population-based understanding of risk factors for stillbirths compared with live births that could assist with reducti...

    Authors: Rakhi Dandona, G. Anil Kumar, Md. Akbar, Debarshi Bhattacharya, Priya Nanda and Lalit Dandona

    Citation: BMC Medicine 2019 17:28

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  19. Content type: Research article

    Newborn telomere length (TL) is considered a potential marker for future disease and lifelong health, but few epidemiological studies have examined the determinants of TL in early life. The study aim was to in...

    Authors: Lina Zhang, Lulu Song, Bingqing Liu, Mingyang Wu, Lulin Wang, Bin Zhang, Chao Xiong, Wei Xia, Yuanyuan Li, Zhongqiang Cao, Youjie Wang and Shunqing Xu

    Citation: BMC Medicine 2019 17:27

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  20. Content type: Research article

    Tuberculosis (TB) remains a significant public health problem in Canadian Inuit communities. In 2016, Canadian Inuit had an incidence rate 35 times the Canadian average. Tobacco use is an important risk factor...

    Authors: Dieynaba S. N’Diaye, Ntwali Placide Nsengiyumva, Aashna Uppal, Olivia Oxlade, Gonzalo G. Alvarez and Kevin Schwartzman

    Citation: BMC Medicine 2019 17:26

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  21. Content type: Research article

    China has transitioned from being one of the fastest-growing populations to among the most rapidly aging countries worldwide. In particular, the population of oldest-old individuals, those aged 80+, is project...

    Authors: Zuyun Liu, Ling Han, Qiushi Feng, Matthew E. Dupre, Danan Gu, Heather G. Allore, Thomas M. Gill and Collin F. Payne

    Citation: BMC Medicine 2019 17:23

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  22. Content type: Research article

    Breast cancer patients who have not previously attended mammography screening may be more likely to discontinue adjuvant hormone therapy and therefore have a worse disease prognosis.

    Authors: Wei He, Louise Eriksson, Sven Törnberg, Fredrik Strand, Per Hall and Kamila Czene

    Citation: BMC Medicine 2019 17:24

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  23. Content type: Research article

    Antibodies against merozoite antigens are key components of malaria immunity. The naturally acquired antibody response to these antigens is generally considered short-lived; however, the underlying mechanisms ...

    Authors: Victor Yman, Michael T. White, Muhammad Asghar, Christopher Sundling, Klara Sondén, Simon J. Draper, Faith H. A. Osier and Anna Färnert

    Citation: BMC Medicine 2019 17:22

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  24. Content type: Research article

    A sizeable fraction of tuberculosis (TB) cases go undiagnosed. By analysing data from enhanced demographic, microbiological and geospatial surveillance of TB registrations, we aimed to identify modifiable pred...

    Authors: Peter MacPherson, McEwen Khundi, Marriott Nliwasa, Augustine T. Choko, Vincent K. Phiri, Emily L. Webb, Peter J. Dodd, Ted Cohen, Rebecca Harris and Elizabeth L. Corbett

    Citation: BMC Medicine 2019 17:21

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  25. Content type: Research article

    There is an increasing recognition that children remain at elevated risk of death following discharge from health facilities in resource-poor settings. Diarrhea has previously been highlighted as a risk factor...

    Authors: Alison Talbert, Moses Ngari, Evasius Bauni, Martha Mwangome, Neema Mturi, Mark Otiende, Kathryn Maitland, Judd Walson and James A. Berkley

    Citation: BMC Medicine 2019 17:20

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  26. Content type: Research article

    A phasic dysregulation of mitochondrial bioenergetics may operate in bipolar disorder, increased in mania and decreased in depression. We aimed to examine efficacy of two add-on treatments in bipolar depression:

    Authors: Michael Berk, Alyna Turner, Gin S. Malhi, Chee H. Ng, Susan M. Cotton, Seetal Dodd, Yuval Samuni, Michelle Tanious, Claire McAulay, Nathan Dowling, Jerome Sarris, Lauren Owen, Astrid Waterdrinker, Deidre Smith and Olivia M. Dean

    Citation: BMC Medicine 2019 17:18

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    The Correction to this article has been published in BMC Medicine 2019 17:35

  27. Content type: Research article

    The risk of hepatic steatosis may be reduced through changes to dietary intakes, but evidence is sparse, especially for dietary patterns including the Mediterranean diet. We investigated the association betwee...

    Authors: Saman Khalatbari-Soltani, Fumiaki Imamura, Soren Brage, Emanuella De Lucia Rolfe, Simon J Griffin, Nicholas J Wareham, Pedro Marques-Vidal and Nita G Forouhi

    Citation: BMC Medicine 2019 17:19

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  28. Content type: Research article

    It is challenging to engage repeat users of unscheduled healthcare with severe health anxiety in psychological help and high service costs are incurred. We investigated whether clinical and economic outcomes w...

    Authors: Richard Morriss, Shireen Patel, Sam Malins, Boliang Guo, Fred Higton, Marilyn James, Mengjun Wu, Paula Brown, Naomi Boycott, Catherine Kaylor-Hughes, Martin Morris, Emma Rowley, Jayne Simpson, David Smart, Michelle Stubley, Joe Kai…

    Citation: BMC Medicine 2019 17:16

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  29. Content type: Research article

    Substantial global progress in the control of malaria in recent years has led to increased commitment to its potential elimination. Whether this is possible in high transmission areas of sub-Saharan Africa rem...

    Authors: A. Björkman, D. Shakely, A. S. Ali, U. Morris, H. Mkali, A. K. Abbas, A-W Al-Mafazy, K. A. Haji, J. Mcha, R. Omar, J. Cook, K. Elfving, M. Petzold, M. C. Sachs, B. Aydin-Schmidt, C. Drakeley…

    Citation: BMC Medicine 2019 17:14

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  30. Content type: Research article

    Pregnancy is associated with widespread change in metabolism, which may be more marked in obese women. Whether lifestyle interventions in obese pregnant women improve pregnancy metabolic profiles remains unkno...

    Authors: Harriet L. Mills, Nashita Patel, Sara L. White, Dharmintra Pasupathy, Annette L. Briley, Diana L. Santos Ferreira, Paul T. Seed, Scott M. Nelson, Naveed Sattar, Kate Tilling, Lucilla Poston and Deborah A. Lawlor

    Citation: BMC Medicine 2019 17:15

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  31. Content type: Mini Review

    Where should I submit my paper? This is a question that young scientists and trainees frequently ask. In this Commentary, we advise on how to make such a decision whilst balancing the risks and benefits. We ar...

    Authors: Clare Fiala and Eleftherios P. Diamandis

    Citation: BMC Medicine 2019 17:12

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  32. Content type: Research article

    Plasmodium falciparum infections with slow parasite clearance following artemisinin-based therapies are widespread in the Greater Mekong Subregion. A molecular marker of the slow clearance phenotype has been iden...


    Citation: BMC Medicine 2019 17:1

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  33. Content type: Research article

    Naltrexone is an opioid antagonist used in many different conditions, both licensed and unlicensed. It is used at widely varying doses from 3 to 250 mg. The aim of this review was to extensively evaluate the s...

    Authors: Monica Bolton, Alex Hodkinson, Shivani Boda, Alan Mould, Maria Panagioti, Sarah Rhodes, Lisa Riste and Harm van Marwijk

    Citation: BMC Medicine 2019 17:10

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    The Commentary to this article has been published in BMC Medicine 2019 17:30

  34. Content type: Research article

    Excessive gestational weight gain (GWG) leads to obstetric complications, maternal postpartum weight retention and an increased risk of offspring obesity. The GeliS study examines the effect of a lifestyle int...

    Authors: Julia Kunath, Julia Günther, Kathrin Rauh, Julia Hoffmann, Lynne Stecher, Eva Rosenfeld, Luzia Kick, Kurt Ulm and Hans Hauner

    Citation: BMC Medicine 2019 17:5

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  35. Content type: Research article

    Recently, studies have examined the underlying patient and practice factors for missed appointments, but less is known about the impact on patient health. People with one or more long-term conditions who fail ...

    Authors: Ross McQueenie, David A. Ellis, Alex McConnachie, Philip Wilson and Andrea E. Williamson

    Citation: BMC Medicine 2019 17:2

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  36. Content type: Research article

    Conflicting results regarding the impact of repeated vaccination on influenza vaccine effectiveness (VE) may cause confusion regarding the benefits of receiving the current season’s vaccine.

    Authors: Lauren C. Ramsay, Sarah A. Buchan, Robert G. Stirling, Benjamin J. Cowling, Shuo Feng, Jeffrey C. Kwong and Bryna F. Warshawsky

    Citation: BMC Medicine 2019 17:9

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  37. Content type: Research article

    The Opti-HER HEART trial aimed to optimize activity while minimizing cardiac risk by combining trastuzumab, pertuzumab, and paclitaxel with non-pegylated liposomal doxorubicin in the treatment of HER2-positive...

    Authors: Joaquín Gavilá, Mafalda Oliveira, Tomás Pascual, Jose Perez-Garcia, Xavier Gonzàlez, Jordi Canes, Laia Paré, Isabel Calvo, Eva Ciruelos, Montserrat Muñoz, Juan A. Virizuela, Isabel Ruiz, Raquel Andrés, Antonia Perelló, Jerónimo Martínez, Serafín Morales…

    Citation: BMC Medicine 2019 17:8

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  38. Content type: Research article

    Knowledge of HIV-1 molecular transmission clusters (MTCs) is important, especially in large-scale datasets, for designing prevention programmes and public health intervention strategies. We used a large-scale ...

    Authors: Dimitrios Paraskevis, Apostolos Beloukas, Kostantinos Stasinos, Nikos Pantazis, Carmen de Mendoza, Norbert Bannert, Laurence Meyer, Robert Zangerle, John Gill, Maria Prins, Antonella d’Arminio Montforte, Anne-Marte Bakken Kran, Kholoud Porter and Giota Touloumi

    Citation: BMC Medicine 2019 17:4

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  39. Content type: Research article

    Risk stratification and management of acute myocardial infarction patients continue to be challenging despite considerable efforts made in the last decades by many clinicians and researchers. The aim of this s...

    Authors: Alessia Vignoli, Leonardo Tenori, Betti Giusti, Panteleimon G. Takis, Serafina Valente, Nazario Carrabba, Daniela Balzi, Alessandro Barchielli, Niccolò Marchionni, Gian Franco Gensini, Rossella Marcucci, Claudio Luchinat and Anna Maria Gori

    Citation: BMC Medicine 2019 17:3

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  40. Content type: Correspondence

    The SMILES trial showed substantial improvement of depressive symptoms following seven consultations on healthy dieting. The very large effect size on depression reduction seems remarkable and we suggest that ...

    Authors: Marc L. Molendijk, Eiko I. Fried and Willem Van der Does

    Citation: BMC Medicine 2018 16:243

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    The original article was published in BMC Medicine 2017 15:23

  41. Content type: Correction

    The original article [1] did not contain comprehensive information regarding two authors’ affiliations that may be considered a potential competing interest.

    Authors: Stewart T. Chang, Violet N. Chihota, Katherine L. Fielding, Alison D. Grant, Rein M. Houben, Richard G. White, Gavin J. Churchyard, Philip A. Eckhoff and Bradley G. Wagner

    Citation: BMC Medicine 2018 16:242

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    The original article was published in BMC Medicine 2018 16:52

  42. Content type: Correction

    The original article [1] contained an error in the presentation of Figure 1; this error has now been rectified and Figure 1 is now presented correctly.

    Authors: Amy Wesolowski, Aimee R. Taylor, Hsiao-Han Chang, Robert Verity, Sofonias Tessema, Jeffrey A. Bailey, T. Alex Perkins, Daniel E. Neafsey, Bryan Greenhouse and Caroline O. Buckee

    Citation: BMC Medicine 2018 16:241

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    The original article was published in BMC Medicine 2018 16:190

  43. Content type: Correspondence

    The SMILES trial was the first intervention study to test dietary improvement as a treatment strategy for depression. Molendijk et al. propose that expectation bias and difficulties with blinding might account...

    Authors: Felice N. Jacka, Adrienne O’Neil, Catherine Itsiopoulos, Rachelle Opie, Sue Cotton, Mohammadreza Mohebbi, David Castle, Sarah Dash, Cathrine Mihalopoulos, Mary Lou Chatterton, Laima Brazionis, Olivia M. Dean, Allison Hodge and Michael Berk

    Citation: BMC Medicine 2018 16:237

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    The original article was published in BMC Medicine 2017 15:23

  44. Content type: Correction

    The original version of this paper [1] did not specify that a website was used in the final year of recruitment, in addition to the other stated recruitment methods.

    Authors: Felice N. Jacka, Adrienne O’Neil, Rachelle Opie, Catherine Itsiopoulos, Sue Cotton, Mohammedreza Mohebbi, David Castle, Sarah Dash, Cathrine Mihalopoulos, Mary Lou Chatterton, Laima Brazionis, Olivia M. Dean, Allison M. Hodge and Michael Berk

    Citation: BMC Medicine 2018 16:236

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    The original article was published in BMC Medicine 2017 15:23