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  1. Content type: Research article

    The present study aims to evaluate the cost-effectiveness of the newly introduced varicella and herpes zoster (HZ) vaccination programmes in Italy. The appropriateness of the introduction of the varicella vacc...

    Authors: Alessia Melegaro, Valentina Marziano, Emanuele Del Fava, Piero Poletti, Marcello Tirani, Caterina Rizzo and Stefano Merler

    Citation: BMC Medicine 2018 16:117

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  2. Content type: Research article

    Intensification of metformin monotherapy with additional glucose-lowering drugs is often required in patients with type 2 diabetes (T2D). This study evaluated changes in HbA1c and weight, as well as treatment ...

    Authors: John Wilding, Thomas Godec, Kamlesh Khunti, Stuart Pocock, Robin Fox, Liam Smeeth, Per Clauson, Peter Fenici, Niklas Hammar and Jesús Medina

    Citation: BMC Medicine 2018 16:116

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  3. Content type: Research article

    The RTS,S/AS01 vaccine for Plasmodium falciparum malaria demonstrated moderate efficacy in 5–17-month-old children in phase 3 trials, and from 2018, the vaccine will be evaluated through a large-scale pilot imple...

    Authors: Alexandra B. Hogan, Peter Winskill, Robert Verity, Jamie T. Griffin and Azra C. Ghani

    Citation: BMC Medicine 2018 16:109

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  4. Content type: Research article

    Caregivers may promote the uptake of science into patient care and the practice of evidence-informed medicine. The purpose of this study was to determine whether caregiver-mediated (non-clinical caregiver-deli...

    Authors: Kirsten M. Fiest, Christiane Job McIntosh, Danielle Demiantschuk, Jeanna Parsons Leigh and Henry T. Stelfox

    Citation: BMC Medicine 2018 16:105

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  5. Content type: Research article

    For patients starting treatment for depression, current guidelines recommend titrating the antidepressant dosage to the maximum of the licenced range if tolerated. When patients do not achieve remission within...

    Authors: Tadashi Kato, Toshi A. Furukawa, Akio Mantani, Ken’ichi Kurata, Hajime Kubouchi, Susumu Hirota, Hirotoshi Sato, Kazuyuki Sugishita, Bun Chino, Kahori Itoh, Yoshio Ikeda, Yoshihiro Shinagawa, Masaki Kondo, Yasumasa Okamoto, Hirokazu Fujita, Motomu Suga…

    Citation: BMC Medicine 2018 16:103

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  6. Content type: Research article

    Genotype-guided warfarin dosing has been shown in some randomized trials to improve anticoagulation outcomes in individuals of European ancestry, yet its utility in Asian patients remains unresolved.

    Authors: Nicholas L. Syn, Andrea Li-Ann Wong, Soo-Chin Lee, Hock-Luen Teoh, James Wei Luen Yip, Raymond CS Seet, Wee Tiong Yeo, William Kristanto, Ping-Chong Bee, LM Poon, Patrick Marban, Tuck Seng Wu, Michael D. Winther, Liam R. Brunham, Richie Soong, Bee-Choo Tai…

    Citation: BMC Medicine 2018 16:104

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  7. Content type: Research article

    The effects of community health worker (CHW) home visiting during the antenatal and postnatal periods in fragile- and conflicted-affected countries such as Afghanistan are not known.

    Authors: Karen M. Edmond, Khaksar Yousufi, Zelaikha Anwari, Sayed Masoud Sadat, Shah Mansoor Staniczai, Ariel Higgins-Steele, Alexandra L. Bellows and Emily R. Smith

    Citation: BMC Medicine 2018 16:106

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  8. Content type: Research article

    The Choosing Wisely campaign highlights the importance of clinical reasoning abilities for competent and reflective physicians. The principles of this campaign should be addressed in undergraduate medical educati...

    Authors: Sascha Ludwig, Nikolai Schuelper, Jamie Brown, Sven Anders and Tobias Raupach

    Citation: BMC Medicine 2018 16:107

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  9. Content type: Research article

    Stratification of cancer patients to identify those with worse prognosis is increasingly important. Through in silico analyses, we recently developed a gene expression-based prognostic score (S3-score) for cle...

    Authors: Florian Büttner, Stefan Winter, Steffen Rausch, Jörg Hennenlotter, Stephan Kruck, Arnulf Stenzl, Marcus Scharpf, Falko Fend, Abbas Agaimy, Arndt Hartmann, Jens Bedke, Matthias Schwab and Elke Schaeffeler

    Citation: BMC Medicine 2018 16:108

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  10. Content type: Research article

    Equitable access to vaccines has been suggested as a priority for low- and middle-income countries (LMICs). However, it is unclear whether providing equitable access is enough to ensure health equity. Furtherm...

    Authors: Angela Y. Chang, Carlos Riumallo-Herl, Joshua A. Salomon, Stephen C. Resch, Logan Brenzel and Stéphane Verguet

    Citation: BMC Medicine 2018 16:102

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  11. Content type: Research article

    Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a worldwide prevalence of 1–2%. In low-resource environments, in particular, early identification and diagnosis is a significant challenge. ...

    Authors: T. Heunis, C. Aldrich, J. M. Peters, S. S. Jeste, M. Sahin, C. Scheffer and P. J. de Vries

    Citation: BMC Medicine 2018 16:101

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  12. Content type: Research article

    The Mediterranean Diet (MedDiet) has been acknowledged as a healthy diet. However, its relation with risk of major chronic diseases in non-Mediterranean countries is inconclusive. The Nordic diet is proposed a...

    Authors: Cecilia Galbete, Janine Kröger, Franziska Jannasch, Khalid Iqbal, Lukas Schwingshackl, Carolina Schwedhelm, Cornelia Weikert, Heiner Boeing and Matthias B. Schulze

    Citation: BMC Medicine 2018 16:99

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  13. Content type: Correspondence

    Malaria at international borders presents particular challenges with regards to elimination. International borders share common malaria ecologies, yet neighboring countries are often at different stages of the...

    Authors: Mohammed H. Al Zahrani, Abdiasiis I. Omar, Abdelmohsin M. O. Abdoon, Ali Adam Ibrahim, Abdullah Alhogail, Mohamed Elmubarak, Yousif Eldirdiry Elamin, Mohammed A. AlHelal, Ali M. Alshahrani, Tarig M. Abdelgader, Ibrahim Saeed, Tageddin B. El Gamri, Mohammed S. Alattas, Abdu A. Dahlan, Abdullah M. Assiri, Joseph Maina…

    Citation: BMC Medicine 2018 16:98

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  14. Content type: Research article

    Globally, illness and life expectancy follow a social gradient that puts people of lower socioeconomic status (SES) at higher risk of dying prematurely. Alcohol consumption has been shown to be a factor contri...

    Authors: Charlotte Probst, Charles D. H. Parry, Hans-Ulrich Wittchen and Jürgen Rehm

    Citation: BMC Medicine 2018 16:97

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  15. Content type: Opinion

    The healthcare system has proved a challenging environment for innovation, especially in the area of health services management and research. This is often attributed to the complexity of the healthcare sector...

    Authors: Katrina M. Long, Fiona McDermott and Graham N. Meadows

    Citation: BMC Medicine 2018 16:94

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  16. Content type: Research article

    Despite limited information on neonatal safety, the transfer of frozen-thawed cleavage-stage embryos with blastomere loss is common in women undergoing in vitro fertilization. We aimed to evaluate the pregnanc...

    Authors: Yan-Ting Wu, Cheng Li, Yi-Min Zhu, Shu-Hua Zou, Qiong-Fang Wu, Li-Ping Wang, Yan Wu, Rong Yin, Chao-Yi Shi, Jing Lin, Zi-Ru Jiang, Yi-Jing Xu, Yun-Fei Su, Jian Zhang, Jian-Zhong Sheng, William D. Fraser…

    Citation: BMC Medicine 2018 16:96

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  17. Content type: Research article

    Existing evidence remains inconclusive as to the association between chronic hepatitis B virus (HBV) infection and the risk of chronic kidney disease (CKD). We prospectively examined the association between ch...

    Authors: Jiahui Si, Canqing Yu, Yu Guo, Zheng Bian, Chenxi Qin, Ling Yang, Yiping Chen, Li Yin, Hui Li, Jian Lan, Junshi Chen, Zhengming Chen, Jun Lv and Liming Li

    Citation: BMC Medicine 2018 16:93

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  18. Content type: Debate

    More than 65 million persons are currently forcibly displaced, of whom more than 22 million are refugees. Conflicts are increasing, and existing ones are becoming more protracted; a refugee remains a refugee f...

    Authors: Paul Spiegel, Rebecca Chanis and Antonio Trujillo

    Citation: BMC Medicine 2018 16:90

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  19. Content type: Research article

    Media depictions and laws passed in state legislatures regulating abortion suggest abortion-related medical emergencies are common. An accurate understanding of abortion-related emergencies is important for in...

    Authors: Ushma D. Upadhyay, Nicole E. Johns, Rebecca Barron, Alice F. Cartwright, Chantal Tapé, Alyssa Mierjeski and Alyson J. McGregor

    Citation: BMC Medicine 2018 16:88

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  20. Content type: Research article

    Polypharmacy is an increasing challenge for primary care. Although sometimes clinically justified, polypharmacy can be inappropriate, leading to undesirable outcomes. Optimising care for polypharmacy necessita...

    Authors: Jenni Burt, Natasha Elmore, Stephen M. Campbell, Sarah Rodgers, Anthony J. Avery and Rupert A. Payne

    Citation: BMC Medicine 2018 16:91

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  21. Content type: Research article

    Global migration is at an all-time high with implications for perinatal health. Migrant women, especially asylum seekers and refugees, represent a particularly vulnerable group. Understanding the impact on the...

    Authors: Nicola Heslehurst, Heather Brown, Augustina Pemu, Hayley Coleman and Judith Rankin

    Citation: BMC Medicine 2018 16:89

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