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  1. Tumor-infiltrating lymphocyte (TIL) therapy has been restricted by intensive lymphodepletion and high-dose intravenous interleukin-2 (IL-2) administration. To address these limitations, we conducted preclinica...

    Authors: Jing Guo, Chunyan Wang, Ning Luo, Yuliang Wu, Wei Huang, Jihui Zhu, Weihui Shi, Jinye Ding, Yao Ge, Chunhong Liu, Zhen Lu, Robert C. Bast Jr, Guihai Ai, Weihong Yang, Rui Wang, Caixia Li…
    Citation: BMC Medicine 2024 22:207
  2. Numerous studies have been conducted to investigate the relationship between ABO and Rhesus (Rh) blood groups and various health outcomes. However, a comprehensive evaluation of the robustness of these associa...

    Authors: Fang-Hua Liu, Jia-Kai Guo, Wei-Yi Xing, Xue-Li Bai, Yu-Jiao Chang, Zhao Lu, Miao Yang, Ying Yang, Wen-Jing Li, Xian-Xian Jia, Tao Zhang, Jing Yang, Jun-Tong Chen, Song Gao, Lang Wu, De-Yu Zhang…
    Citation: BMC Medicine 2024 22:206
  3. It is unclear whether brief interventions using the combined classification of alcohol-metabolizing enzymes aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) together with behavioral changes i...

    Authors: Yukiko Owaki, Hisashi Yoshimoto, Go Saito, Shohei Dobashi, Satoshi Kushio, Akihiro Nakamura, Takahiro Goto, Yusuke Togo, Kazumasa Mori and Hideki Hokazono
    Citation: BMC Medicine 2024 22:205
  4. Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease, and its morbidity and mortality are increasing. At present, there is no specific therapy available. An exacerbat...

    Authors: Sai Wen, Nannan Xu, Lianhui Zhao, Lulu Yang, Hui Yang, Caiyun Chang, Shanshan Wang, Chunmei Qu, Li Song, Wenlu Zou, Yishan He and Gang Wang
    Citation: BMC Medicine 2024 22:204
  5. To the best of our knowledge, no study has investigated the potential joint effect of large for gestational age (LGA) and assisted reproductive technology (ART) on the long-term health of children.

    Authors: Yiyuan Zhang, Kexin Dai, Xiaojing Chen, Linlin Cui and Zi-Jiang Chen
    Citation: BMC Medicine 2024 22:203
  6. Lipid-lowering drugs and antihypertensive drugs are commonly combined for cardiovascular disease (CVD). However, the relationship of combined medications with CVD remains controversial. We aimed to explore the...

    Authors: Ying Li, Hongwei Liu, Chong Shen, Jianxin Li, Fangchao Liu, Keyong Huang, Dongfeng Gu, Yun Li and Xiangfeng Lu
    Citation: BMC Medicine 2024 22:201
  7. Osteosarcoma (OS) is the most common primary malignant bone tumor and is highly prone to metastasis. OS can metastasize to the lymph node (LN) through the lymphatics, and the metastasis of tumor cells reestabl...

    Authors: Yun Liu, Mingwei He, Haijun Tang, Tianyu Xie, Yunhua Lin, Shangyu Liu, Jiming Liang, Feicui Li, Kai Luo, Mingxiu Yang, Hongcai Teng, Xiaoting Luo, Juliang He, Shijie Liao, Qian Huang, Wenyu Feng…
    Citation: BMC Medicine 2024 22:200
  8. The prospective phase III multi-centre L-MOCA trial (NCT03534453) has demonstrated the encouraging efficacy and manageable safety profile of olaparib maintenance therapy in the Asian (mainly Chinese) patients ...

    Authors: Huayi Li, Zikun Peng, Jianqing Zhu, Weidong Zhao, Yi Huang, Ruifang An, Hong Zheng, Pengpeng Qu, Li Wang, Qi Zhou, Danbo Wang, Ge Lou, Jing Wang, Ke Wang, Beihua Kong, Xing Xie…
    Citation: BMC Medicine 2024 22:199
  9. In the context of expanding digital health tools, the health system is ready for Learning Health System (LHS) models. These models, with proper governance and stakeholder engagement, enable the integration of ...

    Authors: Helena Teede, Dominique A. Cadilhac, Tara Purvis, Monique F. Kilkenny, Bruce C.V. Campbell, Coralie English, Alison Johnson, Emily Callander, Rohan S. Grimley, Christopher Levi, Sandy Middleton, Kelvin Hill and Joanne Enticott
    Citation: BMC Medicine 2024 22:198
  10. The aim of this study was to evaluate commonly assumed causal relationships between body mass index (BMI), gestational weight gain (GWG), and adverse pregnancy outcomes, which have formed the basis of guidelin...

    Authors: Jodie M. Dodd, Jennie Louise, Andrea R. Deussen, Megan Mitchell and Lucilla Poston
    Citation: BMC Medicine 2024 22:197
  11. Mobile health (mHealth) technologies have been harnessed in low- and middle-income countries (LMICs) to address the intricate challenges confronting maternal, newborn, and child health (MNCH). This review aspi...

    Authors: Marianne Ravn Knop, Michiko Nagashima-Hayashi, Ruixi Lin, Chan Hang Saing, Mengieng Ung, Sreymom Oy, Esabelle Lo Yan Yam, Marina Zahari and Siyan Yi
    Citation: BMC Medicine 2024 22:196
  12. Diabetic cardiomyopathy (DbCM) is characterized by asymptomatic stage B heart failure (SBHF) caused by diabetes-related metabolic alterations. DbCM is associated with an increased risk of progression to overt ...

    Authors: Iwona Swiatkiewicz, Neeja T. Patel, MaryAnn Villarreal-Gonzalez and Pam R. Taub
    Citation: BMC Medicine 2024 22:195
  13. The reason for higher incidence of atrial fibrillation (AF) in Europe compared with East Asia is unclear. We aimed to investigate the association between modifiable lifestyle factors and lifetime risk of AF in...

    Authors: Hanjin Park, Daehoon Kim, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Dong-min Kim, Jung-Hoon Sung, Hui-Nam Pak, Moon-Hyoung Lee, Gregory Y. H. Lip, Pil-Sung Yang and Boyoung Joung
    Citation: BMC Medicine 2024 22:194
  14. Antidepressants are first-line medications for many psychiatric disorders. However, their widespread long-term use in some indications (e.g., mild depression and insomnia) is concerning. Particularly in older ...

    Authors: Vita Brisnik, Jochen Vukas, Caroline Jung-Sievers, Karoline Lukaschek, G Caleb Alexander, Ulrich Thiem, Petra Thürmann, Cornelius Schüle, Sebastian Fischer, Erika Baum, Michael Drey, Sebastian Harder, Wilhelm Niebling, Ulrike Janka, Olaf Krause, Jochen Gensichen…
    Citation: BMC Medicine 2024 22:193
  15. Peripheral glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) are sensitive markers of neuroinflammation and neuronal damage. Previous studies with highly selected participants have sho...

    Authors: Xiaofei Wang, Ziyan Shi, Yuhan Qiu, Dongren Sun and Hongyu Zhou
    Citation: BMC Medicine 2024 22:192
  16. Healthy Start (HS) is a government scheme in England, Wales and Northern Ireland that offers a financial payment card and free vitamins to families experiencing low income. Pregnant women and families with chi...

    Authors: Millie Barrett, Mark Spires and Christina Vogel
    Citation: BMC Medicine 2024 22:177
  17. Selenium-dependent deiodinases play a central role in thyroid hormone regulation and metabolism. In many European countries, insufficient selenium intake may consequently lead to adverse effects on thyroid fun...

    Authors: Urban Alehagen, Jan Alexander, Jan O. Aaseth, Anders Larsson and Trine B. Opstad
    Citation: BMC Medicine 2024 22:191
  18. Metabolic syndrome (MetS) is becoming prevalent in the pediatric population. The existing pediatric MetS definitions (e.g., the International Diabetes Federation (IDF) definition and the modified National Chol...

    Authors: Xin’nan Zong, Roya Kelishadi, Hae Soon Kim, Peter Schwandt, Tandi E. Matsha, Jose G. Mill, Carmelo Antonio Caserta, Carla Campos Muniz Medeiros, Anastasios Kollias, Peter H. Whincup, Lucia Pacifico, Abel López-Bermejo, Min Zhao, Miaobing Zheng and Bo Xi
    Citation: BMC Medicine 2024 22:190
  19. Sleep loss is a common public health problem that causes hyperalgesia, especially that after surgery, which reduces the quality of life seriously.

    Authors: Yulin Huang, Rui Xu, Qi Liu, Xiao Zhang, Yanting Mao, Yan Yang, Xiaoping Gu, Yue Liu and Zhengliang Ma
    Citation: BMC Medicine 2024 22:189
  20. Floods are the most frequent weather-related disaster, causing significant health impacts worldwide. Limited studies have examined the long-term consequences of flooding exposure.

    Authors: Yao Wu, Danijela Gasevic, Bo Wen, Zhengyu Yang, Pei Yu, Guowei Zhou, Yan Zhang, Jiangning Song, Hong Liu, Shanshan Li and Yuming Guo
    Citation: BMC Medicine 2024 22:188
  21. Lung cancer (LC) survivors are at increased risk for developing a second primary cancer (SPC) compared to the general population. While this risk is particularly high for smoking-related SPCs, the published st...

    Authors: Marian Eberl, Luana F. Tanaka, Klaus Kraywinkel and Stefanie J. Klug
    Citation: BMC Medicine 2024 22:187
  22. Migrants in the UK and Europe face vulnerability to vaccine-preventable diseases (VPDs) due to missed childhood vaccines and doses and marginalisation from health systems. Ensuring migrants receive catch-up va...

    Authors: Alison F. Crawshaw, Lucy P. Goldsmith, Anna Deal, Jessica Carter, Felicity Knights, Farah Seedat, Karen Lau, Sally E. Hayward, Joanna Yong, Desiree Fyle, Nathaniel Aspray, Michiyo Iwami, Yusuf Ciftci, Fatima Wurie, Azeem Majeed, Alice S. Forster…
    Citation: BMC Medicine 2024 22:186
  23. We investigated the effects of a physical activity encouragement intervention based on a smartphone personal health record (PHR) application (app) on step count increases, glycemic control, and body weight in ...

    Authors: Gyuri Kim, Seohyun Kim, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur and Jae Hyeon Kim
    Citation: BMC Medicine 2024 22:185
  24. Although there is a very high comorbidity between tobacco dependence and other addictive disorders, there are only few studies examining the implementation and outcomes of a tobacco cessation program in patien...

    Authors: J. Fuchshuber, H. Schöber, M. Wohlmuth, H. Senra, C. Rominger, A. Schwerdtfeger and H. F. Unterrainer
    Citation: BMC Medicine 2024 22:184
  25. The exact mechanisms linking the gut microbiota and social behavior are still under investigation. We aimed to explore the role of the gut microbiota in shaping social behavior deficits using selectively bred ...

    Authors: Oryan Agranyoni, Debpali Sur, Sivan Amidror, Nuphar Shidlovsky, Anastasia Bagaev, Nissan Yissachar, Albert Pinhasov and Shiri Navon-Venezia
    Citation: BMC Medicine 2024 22:182
  26. Early pregnancy is a critical window for neural system programming; however, the association of first-trimester fetal size with children’s neurodevelopment remains to be assessed. This study aimed to explore t...

    Authors: Xinmei Chen, Hongxiu Liu, Yuanyuan Li, Wenxin Zhang, Aifen Zhou, Wei Xia and Shunqing Xu
    Citation: BMC Medicine 2024 22:181
  27. To prevent tobacco use in Korea, the national quitline number was added to tobacco packages in December 2012, tobacco prices were raised by 80% in January 2015, and graphic health warning labels were placed on...

    Authors: Taiyue Jin, Juhee Seo, Shinhee Ye, Seulbi Lee, Eun Young Park, Jin-Kyoung Oh, Changwoo Han and Byungmi Kim
    Citation: BMC Medicine 2024 22:180
  28. Authors: Long Gao, Yanyan Lin, Ping Yue, Shuyan Li, Yong Zhang, Ningning Mi, Mingzhen Bai, Wenkang Fu, Zhili Xia, Ningzu Jiang, Jie Cao, Man Yang, Yanni Ma, Fanxiang Zhang, Chao Zhang, Joseph W. Leung…
    Citation: BMC Medicine 2024 22:179

    The original article was published in BMC Medicine 2023 21:294

  29. There is an urgent unmet need for effective initial treatment for acute graft-versus-host disease (aGVHD) adding to the standard first-line therapy with corticosteroids after allogeneic haematopoietic stem cel...

    Authors: Yu Wang, Qi-Fa Liu, De-Pei Wu, Zheng-Li Xu, Ting-Ting Han, Yu-Qian Sun, Fen Huang, Zhi-Ping Fan, Na Xu, Feng Chen, Ye Zhao, Yuan Kong, Xiao-Dong Mo, Lan-Ping Xu, Xiao-Hui Zhang, Kai-Yan Liu…
    Citation: BMC Medicine 2024 22:176
  30. Hybrid closed-loop (HCL) systems seamlessly interface continuous glucose monitoring (CGM) with insulin pumps, employing specialised algorithms and user-initiated automated insulin delivery. This study aimed to...

    Authors: Sze May Ng, Neil P. Wright, Diana Yardley, Fiona Campbell, Tabitha Randell, Nicola Trevelyan, Atrayee Ghatak and Peter C. Hindmarsh
    Citation: BMC Medicine 2024 22:175
  31. Osimertinib has become standard care for epidermal growth factor receptor (EGFR)-positive non-small cell lung cancer (NSCLC) patients whereas drug resistance remains inevitable. Now we recognize that the inter...

    Authors: Ruoshuang Han, Haoyue Guo, Jinpeng Shi, Sha Zhao, Yijun Jia, Xiaozhen Liu, Yiwei Liu, Lei Cheng, Chao Zhao, Xuefei Li and Caicun Zhou
    Citation: BMC Medicine 2024 22:174
  32. The molecular pathways linking short and long sleep duration with incident diabetes mellitus (iDM) and incident coronary heart disease (iCHD) are not known. We aimed to identify circulating protein patterns as...

    Authors: Thomas Svensson, Akiko Kishi Svensson, Mariusz Kitlinski, Gunnar Engström, Jan Nilsson, Marju Orho-Melander, Peter M. Nilsson and Olle Melander
    Citation: BMC Medicine 2024 22:173
  33. Lenvatinib is widely used in treatment of unresectable hepatocellular carcinoma (uHCC), but the benefit of its combination with immunotherapy needs to be verified. This study evaluated the efficacy and safety ...

    Authors: Li Xu, Jinzhang Chen, Chang Liu, Xiaoling Song, Yanqiao Zhang, Haitao Zhao, Sheng Yan, Weidong Jia, Zheng Wu, Yabing Guo, Jiayin Yang, Wei Gong, Yue Ma, Xiaobo Yang, Zhenzhen Gao, Nu Zhang…
    Citation: BMC Medicine 2024 22:172
  34. Little is known about the safety and efficacy of discontinuing antiplatelet therapy via LMWH bridging therapy in elderly patients with coronary stents implanted for > 12 months undergoing non-cardiac surgery. ...

    Authors: Bin Wang, Yanhui Su, Cong Ma, Lining Xu, Qunxia Mao, Wenjia Cheng, Qingming Lu, Ying Zhang, Rong Wang, Yan Lu, Jing He, Shihao Chen, Lei Chen, Tianzhi Li and Linggen Gao
    Citation: BMC Medicine 2024 22:171
  35. The stalling global progress in malaria control highlights the need for novel tools for malaria elimination, including transmission-blocking vaccines. Transmission-blocking vaccines aim to induce human antibod...

    Authors: M. Alkema, M. J. Smit, C. Marin-Mogollon, K. Totté, K. Teelen, G. J. van Gemert, M. van de Vegte-Bolmer, B. G. Mordmüller, J. M. Reimer, K. L. Lövgren-Bengtsson, R. W. Sauerwein, T. Bousema, J. Plieskatt, M. Theisen, M. M. Jore and M. B. B. McCall
    Citation: BMC Medicine 2024 22:170
  36. Most studies on the impact of the COVID-19 pandemic on depression burden focused on the earlier pandemic phase specific to lockdowns, but the longer-term impact of the pandemic is less well-studied. In this po...

    Authors: Vivien Kin Yi Chan, Yi Chai, Sandra Sau Man Chan, Hao Luo, Mark Jit, Martin Knapp, David Makram Bishai, Michael Yuxuan Ni, Ian Chi Kei Wong and Xue Li
    Citation: BMC Medicine 2024 22:169
  37. Undiagnosed type 2 diabetes (T2D) is a global problem. Current strategies for diagnosis in Sweden include screening individuals within primary healthcare who are of high risk, such as those with hypertension, ...

    Authors: Hrafnhildur Gudjonsdottir, Per Tynelius, Nouha Saleh Stattin, Diego Yacamán Méndez, Anton Lager and Boel Brynedal
    Citation: BMC Medicine 2024 22:168
  38. The prevalence of depression among people with chronic pain remains unclear due to the heterogeneity of study samples and definitions of depression. We aimed to identify sources of variation in the prevalence ...

    Authors: Lingxiao Chen, Claire E Ashton-James, Baoyi Shi, Maja R Radojčić, David B Anderson, Yujie Chen, David B Preen, John L Hopper, Shuai Li, Minh Bui, Paula R Beckenkamp, Nigel K Arden, Paulo H Ferreira, Hengxing Zhou, Shiqing Feng and Manuela L Ferreira
    Citation: BMC Medicine 2024 22:167
  39. The co-administration of drugs known to interact greatly impacts morbidity, mortality, and health economics. This study aims to examine the drug–drug interaction (DDI) phenomenon with a large-scale longitudina...

    Authors: Jon Sánchez-Valle, Rion Brattig Correia, Marta Camacho-Artacho, Rosalba Lepore, Mauro M. Mattos, Luis M. Rocha and Alfonso Valencia
    Citation: BMC Medicine 2024 22:166
  40. Unresectable intrahepatic cholangiocarcinoma (iCCA) has a poor prognosis despite treatment with standard combination chemotherapy. We aimed to evaluate the efficacy and safety of radiotherapy in combination wi...

    Authors: Meiyan Zhu, Meng Jin, Xiao Zhao, Shunli Shen, Yihan Chen, Han Xiao, Guangyan Wei, Qiang He, Bin Li and Zhenwei Peng
    Citation: BMC Medicine 2024 22:165
  41. Tobacco smoking affects women’s fertility and is associated with substantial risks of adverse pregnancy outcomes. This study explored trends by socioeconomic position in patterns of smoking, use of non-combust...

    Authors: Sarah E. Jackson, Jamie Brown, Caitlin Notley, Lion Shahab and Sharon Cox
    Citation: BMC Medicine 2024 22:99
  42. The metabolic benefits of bariatric surgery that contribute to the alleviation of metabolic dysfunction-associated steatotic liver disease (MASLD) have been reported. However, the processes and mechanisms unde...

    Authors: Chengcan Yang, Dongzi Zhu, Chaofan Liu, Wenyue Wang, Yining He, Bing Wang and Meiyi Li
    Citation: BMC Medicine 2024 22:164
  43. Defining healthcare facility catchment areas is a key step in predicting future healthcare demand in epidemic settings. Forecasts of hospitalisations can be informed by leading indicators measured at the commu...

    Authors: Sophie Meakin and Sebastian Funk
    Citation: BMC Medicine 2024 22:163
  44. The COVID-19 pandemic resulted in major inequalities in infection and disease burden between areas of varying socioeconomic deprivation in many countries, including England. Areas of higher deprivation tend to...

    Authors: Lucy Goodfellow, Edwin van Leeuwen and Rosalind M. Eggo
    Citation: BMC Medicine 2024 22:162
  45. Lung health is increasingly recognized as an essential factor in mental health. However, prospective evidence on lung function with incident depression remains to be determined. The study aimed to examine the ...

    Authors: Wei Hu, Bao-Peng Liu and Cun-Xian Jia
    Citation: BMC Medicine 2024 22:160
  46. Long covid (post covid-19 condition) is a complex condition with diverse manifestations, uncertain prognosis and wide variation in current approaches to management. There have been calls for formal quality sta...

    Authors: Trisha Greenhalgh, Julie L. Darbyshire, Cassie Lee, Emma Ladds and Jenny Ceolta-Smith
    Citation: BMC Medicine 2024 22:159
  47. ANKRD11 (ankyrin repeat domain 11) is a chromatin regulator and the only gene associated with KBG syndrome, a rare neurodevelopmental disorder. We have previously shown that Ankrd11 regulates murine embryonic cor...

    Authors: Kara Goodkey, Anita Wischmeijer, Laurence Perrin, Adrianne E. S. Watson, Leenah Qureshi, Duccio Maria Cordelli, Francesco Toni, Maria Gnazzo, Francesco Benedicenti, Monique Elmaleh-Bergès, Karen J. Low and Anastassia Voronova
    Citation: BMC Medicine 2024 22:158