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  1. Minireview

    What makes gouty inflammation so variable?

    Acute gout arthritis flares contribute dominantly to gout-specific impaired health-related quality of life, representing a progressively increasing public health problem. Flares can be complex and expensive to...

    Robert Terkeltaub

    BMC Medicine 2017 15:158

    Published on: 18 August 2017

  2. Commentary

    Circulating tumor DNA for personalized lung cancer monitoring

    Advances in deep sequencing technology have led to developments in personalized medicine. Here, we describe the implications of a recent investigation that sequenced ctDNA from the plasma of non-small cell lun...

    Clare Fiala and Eleftherios P. Diamandis

    BMC Medicine 2017 15:157

    Published on: 17 August 2017

  3. Research article

    Intervention Now to Eliminate Repeat Unintended Pregnancy in Teenagers (INTERUPT): a systematic review of intervention effectiveness and cost-effectiveness, and qualitative and realist synthesis of implementation factors and user engagement

    Unintended repeat conceptions can result in emotional, psychological and educational harm to young women, often with enduring implications for their life chances. This study aimed to identify which young women...

    Rabeea’h W. Aslam, Maggie Hendry, Andrew Booth, Ben Carter, Joanna M. Charles, Noel Craine, Rhiannon Tudor Edwards, Jane Noyes, Lupetu Ives Ntambwe, Diana Pasterfield, Jo Rycroft-Malone, Nefyn Williams and Rhiannon Whitaker

    BMC Medicine 2017 15:155

    Published on: 15 August 2017

  4. Research article

    Gestational hypertensive disorders and retinal microvasculature: the Generation R Study

    Changes in the microvasculature associated with pre-eclampsia and gestational hypertension have been proposed as a potential pathway in the development of cardiovascular disease. We examined whether gestationa...

    Laura Benschop, Sarah Schalekamp–Timmermans, Jeanine E. Roeters van Lennep, Vincent W. V. Jaddoe, Tien Yin Wong, Carol Y. Cheung, Eric A. P. Steegers and Kamran M. Ikram

    BMC Medicine 2017 15:153

    Published on: 14 August 2017

  5. Research article

    Risk and predictors of psoriasis in patients with breast cancer: a Swedish population-based cohort study

    The risk of psoriasis in patients with breast cancer is largely unknown, as available evidence is limited to case findings. We systematically examined the incidence and risk factors of psoriasis in patients wi...

    Haomin Yang, Judith S. Brand, Jingmei Li, Jonas F. Ludvigsson, Emilio Ugalde-Morales, Flaminia Chiesa, Per Hall and Kamila Czene

    BMC Medicine 2017 15:154

    Published on: 11 August 2017

  6. Research article

    Characterizing measles transmission in India: a dynamic modeling study using verbal autopsy data

    Decreasing trends in measles mortality have been reported in recent years. However, such estimates of measles mortality have depended heavily on assumed regional measles case fatality risks (CFRs) and made lit...

    Stéphane Verguet, Edward O. Jones, Mira Johri, Shaun K. Morris, Wilson Suraweera, Cindy L. Gauvreau, Prabhat Jha and Mark Jit

    BMC Medicine 2017 15:151

    Published on: 10 August 2017

  7. Research article

    Consistency and sources of divergence in recommendations on screening with questionnaires for presently experienced health problems or symptoms: a comparison of recommendations from the Canadian Task Force on Preventive Health Care, UK National Screening Committee, and US Preventive Services Task Force

    Recently, health screening recommendations have gone beyond screening for early-stage, asymptomatic disease to include “screening” for presently experienced health problems and symptoms using self-report quest...

    Brett D. Thombs, Nazanin Saadat, Kira E. Riehm, Justin Michael Karter, Akansha Vaswani, Bonnie K. Andrews, Peter Simons and Lisa Cosgrove

    BMC Medicine 2017 15:150

    Published on: 9 August 2017

  8. Research article

    Pregnancy, pregnancy loss, and the risk of cardiovascular disease in Chinese women: findings from the China Kadoorie Biobank

    Pregnancy and pregnancy loss may be linked to cardiovascular disease (CVD). However, the evidence is still inconsistent, especially in East Asians, whose reproductive patterns differ importantly from those in ...

    Sanne A. E. Peters, Ling Yang, Yu Guo, Yiping Chen, Zheng Bian, Xiaocao Tian, Liang Chang, Shuo Zhang, Jiaqiu Liu, Tao Wang, Junshi Chen, Liming Li, Mark Woodward and Zhengming Chen

    BMC Medicine 2017 15:148

    Published on: 8 August 2017

  9. Research article

    The clinical utility of the urine-based lateral flow lipoarabinomannan assay in HIV-infected adults in Myanmar: an observational study

    The use of the point-of-care lateral flow lipoarabinomannan (LF-LAM) test may expedite tuberculosis (TB) diagnosis in HIV-positive patients. However, the test’s clinical utility is poorly defined outside sub-S...

    Swe Swe Thit, Ne Myo Aung, Zaw Win Htet, Mark A. Boyd, Htin Aung Saw, Nicholas M. Anstey, Tint Tint Kyi, David A. Cooper, Mar Mar Kyi and Josh Hanson

    BMC Medicine 2017 15:145

    Published on: 4 August 2017

  10. Research article

    Clinical and laboratory predictors of death in African children with features of severe malaria: a systematic review and meta-analysis

    The criteria for defining severe malaria have evolved over the last 20 years. We aimed to assess the strength of association of death with features currently characterizing severe malaria through a systematic ...

    Paulina Sypniewska, Jose F. Duda, Isabella Locatelli, Clotilde Rambaud Althaus, Fabrice Althaus and Blaise Genton

    BMC Medicine 2017 15:147

    Published on: 3 August 2017

  11. Review

    The renin–angiotensin system: a possible new target for depression

    Depression remains a debilitating condition with an uncertain aetiology. Recently, attention has been given to the renin–angiotensin system. In the central nervous system, angiotensin II may be important in mu...

    João Vian, Círia Pereira, Victor Chavarria, Cristiano Köhler, Brendon Stubbs, João Quevedo, Sung-Wan Kim, André F. Carvalho, Michael Berk and Brisa S. Fernandes

    BMC Medicine 2017 15:144

    Published on: 1 August 2017

  12. Research article

    The cross-national epidemiology of social anxiety disorder: Data from the World Mental Health Survey Initiative

    There is evidence that social anxiety disorder (SAD) is a prevalent and disabling disorder. However, most of the available data on the epidemiology of this condition originate from high income countries in the...

    Dan J. Stein, Carmen C. W. Lim, Annelieke M. Roest, Peter de Jonge, Sergio Aguilar-Gaxiola, Ali Al-Hamzawi, Jordi Alonso, Corina Benjet, Evelyn J. Bromet, Ronny Bruffaerts, Giovanni de Girolamo, Silvia Florescu, Oye Gureje, Josep Maria Haro, Meredith G. Harris, Yanling He…

    BMC Medicine 2017 15:143

    Published on: 31 July 2017

  13. Research article

    What works for whom in the management of diabetes in people living with dementia: a realist review

    Dementia and diabetes mellitus are common long-term conditions and co-exist in a large number of older people. People living with dementia (PLWD) may be less able to manage their diabetes, putting them at incr...

    Frances Bunn, Claire Goodman, Peter Reece Jones, Bridget Russell, Daksha Trivedi, Alan Sinclair, Antony Bayer, Greta Rait, Jo Rycroft-Malone and Christopher Burton

    BMC Medicine 2017 15:141

    Published on: 28 July 2017

  14. Research article

    Epidemiology and outcomes of people with dementia, delirium, and unspecified cognitive impairment in the general hospital: prospective cohort study of 10,014 admissions

    Cognitive impairment of various kinds is common in older people admitted to hospital, but previous research has usually focused on single conditions in highly-selected groups and has rarely examined associatio...

    Emma L. Reynish, Simona M. Hapca, Nicosha De Souza, Vera Cvoro, Peter T. Donnan and Bruce Guthrie

    BMC Medicine 2017 15:140

    Published on: 27 July 2017

  15. Opinion

    The public health value of vaccines beyond efficacy: methods, measures and outcomes

    Assessments of vaccine efficacy and safety capture only the minimum information needed for regulatory approval, rather than the full public health value of vaccines. Vaccine efficacy provides a measure of prop...

    A. Wilder-Smith, I. Longini, P. L. Zuber, T. Bärnighausen, W. J. Edmunds, N. Dean, V. Masserey Spicher, M. R. Benissa and B. D. Gessner

    BMC Medicine 2017 15:138

    Published on: 26 July 2017

  16. Research article

    Impact of ischemic preconditioning on surgical treatment of brain tumors: a single-center, randomized, double-blind, controlled trial

    Postoperative ischemia is a frequent phenomenon in patients with brain tumors and is associated with postoperative neurological deficits and impaired overall survival. Particularly in the field of cardiac and ...

    Arthur H. A. Sales, Melanie Barz, Stefanie Bette, Benedikt Wiestler, Yu-Mi Ryang, Bernhard Meyer, Martin Bretschneider, Florian Ringel and Jens Gempt

    BMC Medicine 2017 15:137

    Published on: 25 July 2017

  17. Opinion

    Ethics review in compassionate use

    Compassionate use is the use of unapproved drugs outside of clinical trials. So far, compassionate use regulations have been introduced in the US, Canada, many European countries, Australia and Brazil, and tre...

    Jan Borysowski, Hans-Jörg Ehni and Andrzej Górski

    BMC Medicine 2017 15:136

    Published on: 24 July 2017

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