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  1. Enhancer of zeste homolog 2 (EZH2)-mediated histone 3 lysine 27 trimethylation (H3K27me3) is a transcription silencing mark, which is indispensable for cell lineage specification at the early blastocyst stage....

    Authors: Ya-nan Zhu, Xiao-wen Gan, Fan Pan, Xiao-tian Ni, Leslie Myatt, Wang-sheng Wang and Kang Sun
    Citation: BMC Medicine 2022 20:189
  2. Long distance heavy goods vehicle (HGV) drivers exhibit higher than nationally representative rates of obesity, and obesity-related co-morbidities, and are underserved in terms of health promotion initiatives....

    Authors: Stacy A. Clemes, Veronica Varela-Mato, Danielle H. Bodicoat, Cassandra L. Brookes, Yu-Ling Chen, Charlotte L. Edwardson, Laura J. Gray, Amber J. Guest, Vicki Johnson, Fehmidah Munir, Nicola J. Paine, Gerry Richardson, Katharina Ruettger, Mohsen Sayyah, Aron Sherry, Ana Suazo Di Paola…
    Citation: BMC Medicine 2022 20:195
  3. Stroke is one of the major challenges for the global healthcare system, which makes it necessary to explore the relationship between various modifiable factors and stroke risk. Recently, numerous meta-analyses...

    Authors: Na Guo, Ying Zhu, Dandan Tian, Yating Zhao, Chenguang Zhang, Changqing Mu, Chen Han, Ruixia Zhu and Xu Liu
    Citation: BMC Medicine 2022 20:194
  4. Whether the associations of time spent in screen-based sedentary activities with CHD vary by genetic susceptibility is currently unknown. The objective of this study was to examine the interplay of genetic sus...

    Authors: Youngwon Kim, Shiu Lun Au Yeung, Stephen J. Sharp, Mengyao Wang, Haeyoon Jang, Shan Luo, Soren Brage and Katrien Wijndaele
    Citation: BMC Medicine 2022 20:188
  5. It was urgent and necessary to synthesize the evidence for vaccine effectiveness (VE) against SARS-CoV-2 variants of concern (VOC). We conducted a systematic review and meta-analysis to provide a comprehensive...

    Authors: Baoqi Zeng, Le Gao, Qingxin Zhou, Kai Yu and Feng Sun
    Citation: BMC Medicine 2022 20:200
  6. As we are confronted with more transmissible/severe variants with immune escape and the waning of vaccine efficacy, it is particularly relevant to understand how the social contacts of individuals at greater r...

    Authors: Aurélie Godbout, Mélanie Drolet, Myrto Mondor, Marc Simard, Chantal Sauvageau, Gaston De Serres and Marc Brisson
    Citation: BMC Medicine 2022 20:199
  7. Transparency and reproducibility are expected to be normative practices in clinical trials used for decision-making on marketing authorisations for new medicines. This registered report introduces a cross-sect...

    Authors: Maximilian Siebert, Jeanne Gaba, Alain Renault, Bruno Laviolle, Clara Locher, David Moher and Florian Naudet
    Citation: BMC Medicine 2022 20:177
  8. The temporal relationship between adiposity and gut microbiota was unexplored. Whether some gut microbes lie in the pathways from adiposity to insulin resistance is less clear. Our study aims to reveal the tem...

    Authors: Kui Deng, Menglei Shuai, Zheqing Zhang, Zengliang Jiang, Yuanqing Fu, Luqi Shen, Ju-Sheng Zheng and Yu-ming Chen
    Citation: BMC Medicine 2022 20:171
  9. Recent years have seen important improvements in available preventive treatment regimens for tuberculosis (TB), and research is ongoing to develop these further. To assist with the formulation of target produc...

    Authors: Juan F. Vesga, Christian Lienhardt, Placide Nsengiyumva, Jonathon R. Campbell, Olivia Oxlade, Saskia den Boon, Dennis Falzon, Kevin Schwartzman, Gavin Churchyard and Nimalan Arinaminpathy
    Citation: BMC Medicine 2022 20:182
  10. The ubiquity of Internet connectivity, and widespread unmet needs, requires investigations of digital interventions for people seeking help with their drinking. The objective of this study was to test the effe...

    Authors: Marcus Bendtsen, Katarina Åsberg and Jim McCambridge
    Citation: BMC Medicine 2022 20:176
  11. This study examines mental, neurological, and substance use (MNS) service usage within refugee camp primary health care facilities in low- and middle-income countries (LMICs) by analyzing surveillance data fro...

    Authors: Shoshanna L. Fine, Jeremy C. Kane, Paul B. Spiegel, Wietse A. Tol and Peter Ventevogel
    Citation: BMC Medicine 2022 20:183
  12. Cytokines have been reported to alter the response to immune checkpoint inhibitors (ICIs) in patients with the tumor in accordance with their plasma concentrations. Here, we aimed to identify the key cytokines...

    Authors: Chengming Liu, Lu Yang, Haiyan Xu, Sufei Zheng, Zhanyu Wang, Sihui Wang, Yaning Yang, Shuyang Zhang, Xiaoli Feng, Nan Sun, Yan Wang and Jie He
    Citation: BMC Medicine 2022 20:187
  13. Fragile X syndrome (FXS), the most prevalent inherited intellectual disability and one of the most common monogenic forms of autism, is caused by a loss of fragile X messenger ribonucleoprotein 1 (FMR1). We ha...

    Authors: Sahar Javadi, Yue Li, Jie Sheng, Lucy Zhao, Yao Fu, Daifeng Wang and Xinyu Zhao
    Citation: BMC Medicine 2022 20:163
  14. Deregulation of cell-cycle pathway is ubiquitously observed in human papillomavirus negative (HPVneg) head and neck squamous cell carcinoma (HNSCC). Despite being an attractive target, CDK4/6 inhibition using pal...

    Authors: Ziyue Gu, Chaoji Shi, Jiayi Li, Yong Han, Bao Sun, Wuchang Zhang, Jing Wu, Guoyu Zhou, Weimin Ye, Jiang Li, Zhiyuan Zhang and Rong Zhou
    Citation: BMC Medicine 2022 20:175
  15. Randomized controlled trials (RCTs) and cohort studies are the most common study design types used to assess the treatment effects of medical interventions. To evaluate the agreement of effect estimates betwee...

    Authors: Nils Bröckelmann, Sara Balduzzi, Louisa Harms, Jessica Beyerbach, Maria Petropoulou, Charlotte Kubiak, Martin Wolkewitz, Joerg J. Meerpohl and Lukas Schwingshackl
    Citation: BMC Medicine 2022 20:174
  16. The association between vitamin E and cancer risk has been widely investigated by observational studies, but the findings remain inconclusive. Here, we aimed to evaluate the causal effect of circulating vitami...

    Authors: Junyi Xin, Xia Jiang, Shuai Ben, Qianyu Yuan, Li Su, Zhengdong Zhang, David C. Christiani, Mulong Du and Meilin Wang
    Citation: BMC Medicine 2022 20:168
  17. Diverse genomic breakpoints of fusions that localize to intronic, exonic, or intergenic regions have been identified by DNA next-generation sequencing (NGS), but the role of exonic breakpoints remains elusive....

    Authors: Weihua Li, Rui Wan, Lei Guo, Geyun Chang, Dong Jiang, Lin Meng and Jianming Ying
    Citation: BMC Medicine 2022 20:160
  18. Thymic epithelial tumors (TETs) are rare malignancies and the treatment options are limited. We aimed to evaluate the efficacy and safety of apatinib, an angiogenesis inhibitor, in advanced TETs.

    Authors: Zhengbo Song, Guangyuan Lou, Yina Wang, Zhiping Yang, Wenxian Wang, Yongling Ji, Shiqing Chen, Chunwei Xu, Xiao Hu and Yiping Zhang
    Citation: BMC Medicine 2022 20:154
  19. Mobile and migrant populations (MMPs) pose a unique challenge to disease elimination campaigns as they are often hard to survey and reach with treatment. While some elimination efforts have had success reachin...

    Authors: Molly W Adams, Elizabeth G Sutherland, Erin L Eckert, Khalida Saalim and Richard Reithinger
    Citation: BMC Medicine 2022 20:172
  20. Identifying the causal genes at the risk loci and elucidating their roles in schizophrenia (SCZ) pathogenesis remain significant challenges. To explore risk variants associated with gene expression in the huma...

    Authors: Chengcheng Zhang, Xiaojing Li, Liansheng Zhao, Rong Liang, Wei Deng, Wanjun Guo, Qiang Wang, Xun Hu, Xiangdong Du, Pak Chung Sham, Xiongjian Luo and Tao Li
    Citation: BMC Medicine 2022 20:169
  21. Anlotinib, an oral small molecule tyrosine kinase inhibitor targeting VEGFR 1/2/3, FGFR 1-4, PDGFR a/β, and c-kit, had demonstrated prolonged progression-free survival (PFS) in refractory metastatic colorectal...

    Authors: Yue Liu, Qian Xiao, Jinjie He, Hanguang Hu, Jinlin Du, Yuping Zhu, Jiaqi Chen, Zhuo Liu, Jianping Wang, Lifeng Sun, Dong Xu, Jun Li, Xiujun Liao, Jianwei Wang, Yibo Cai, Cheng Cai…
    Citation: BMC Medicine 2022 20:155
  22. Previous studies of primarily Western populations have reported contrasting associations of dairy consumption with certain cancers, including a positive association with prostate cancer and inverse association...

    Authors: Maria G. Kakkoura, Huaidong Du, Yu Guo, Canqing Yu, Ling Yang, Pei Pei, Yiping Chen, Sam Sansome, Wing Ching Chan, Xiaoming Yang, Lei Fan, Jun Lv, Junshi Chen, Liming Li, Timothy J. Key and Zhengming Chen
    Citation: BMC Medicine 2022 20:134
  23. In non-small cell lung cancer (NSCLC) patients receiving immune checkpoint inhibitors (ICIs), higher blood tumor mutational burden (bTMB) was usually associated with better progression-free survival (PFS) and ...

    Authors: Wei Nie, Zhi-Jie Wang, Kai Zhang, Bing Li, Yi-Ran Cai, Feng-Cai Wen, Ding Zhang, Yue-Zong Bai, Xue-Yan Zhang, Shu-Yuan Wang, Lei Cheng, Hua Zhong, Li Liu, Jie Wang and Bao-Hui Han
    Citation: BMC Medicine 2022 20:170
  24. The association of adiposity with prostate cancer specific mortality remains unclear. We examined how adiposity relates to fatal prostate cancer and described the cross-sectional associations of commonly used ...

    Authors: Aurora Perez-Cornago, Yashvee Dunneram, Eleanor L. Watts, Timothy J. Key and Ruth C. Travis
    Citation: BMC Medicine 2022 20:143
  25. Practical guidance is needed regarding the vaccination of coronavirus disease 2019 (COVID-19) convalescent individuals in resource-limited countries. It includes the number of vaccine doses that should be give...

    Authors: Chang Kyung Kang, Hyun Mu Shin, Pyoeng Gyun Choe, Jiyoung Park, Jisu Hong, Jung Seon Seo, Yung Hie Lee, Euijin Chang, Nam Joong Kim, Minji Kim, Yong-Woo Kim, Hang-Rae Kim, Chang-Han Lee, Jun-Young Seo, Wan Beom Park and Myoung-don Oh
    Citation: BMC Medicine 2022 20:181
  26. Necrotising soft tissue infections (NSTIs) are rapidly progressing bacterial infections usually caused by either several pathogens in unison (polymicrobial infections) or Streptococcus pyogenes (mono-microbial in...

    Authors: Sanjeevan Jahagirdar, Lorna Morris, Nirupama Benis, Oddvar Oppegaard, Mattias Svenson, Ole Hyldegaard, Steinar Skrede, Anna Norrby-Teglund, Vitor A. P. Martins dos Santos and Edoardo Saccenti
    Citation: BMC Medicine 2022 20:173
  27. Recommended cardiovascular disease (CVD) prediction tools do not account for competing mortality risk and over-predict incident CVD in older and multimorbid people. The aim of this study was to derive and vali...

    Authors: Shona J. Livingstone, Bruce Guthrie, Peter T. Donnan, Alexander Thompson and Daniel R. Morales
    Citation: BMC Medicine 2022 20:152
  28. Congenital long QT syndrome (LQTS) is a rare heart disease caused by various underlying mutations. Most general cardiologists do not routinely see patients with congenital LQTS and may not always recognize the...

    Authors: Simona Aufiero, Hidde Bleijendaal, Tomas Robyns, Bert Vandenberk, Christian Krijger, Connie Bezzina, Aeilko H. Zwinderman, Arthur A. M. Wilde and Yigal M. Pinto
    Citation: BMC Medicine 2022 20:162
  29. Effective targeted prevention of type 2 diabetes (T2D) depends on accurate prediction of disease risk. We assessed the role of metabolomic profiling in improving T2D risk prediction beyond conventional risk fa...

    Authors: Fiona Bragg, Eirini Trichia, Diego Aguilar-Ramirez, Jelena Bešević, Sarah Lewington and Jonathan Emberson
    Citation: BMC Medicine 2022 20:159
  30. Although social isolation has been associated with a higher mortality risk, little is known about the potential different impacts of face-to-face and non-face-to-face isolation on mortality. We examined the pr...

    Authors: Jiao Wang, Wei Sen Zhang, Chao Qiang Jiang, Feng Zhu, Ya Li Jin, Kar Keung Cheng, Tai Hing Lam and Lin Xu
    Citation: BMC Medicine 2022 20:178
  31. In December 2019, a new coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and associated disease, coronavirus disease 2019 (COVID-19), was identified in China. This virus spread quickly...

    Authors: Godfrey Bwire, Alex Riolexus Ario, Patricia Eyu, Felix Ocom, Joseph F. Wamala, Kwadwo A. Kusi, Latif Ndeketa, Kondwani C. Jambo, Rhoda K. Wanyenze and Ambrose O. Talisuna
    Citation: BMC Medicine 2022 20:167
  32. Over the last two centuries, researchers developed several assessments to evaluate the multidimensional construct of imagery. However, no comprehensive systematic review (SR) exists for imagery ability evaluat...

    Authors: Zorica Suica, Frank Behrendt, Szabina Gäumann, Ulrich Gerth, Arno Schmidt-Trucksäss, Thierry Ettlin and Corina Schuster-Amft
    Citation: BMC Medicine 2022 20:166
  33. Persistent fever, defined as fever lasting for 7 days or more at first medical evaluation, has been hardly investigated as a separate clinical entity in the tropics. This study aimed at exploring the frequenci...

    Authors: Emmanuel Bottieau, Lukas Van Duffel, Sayda El Safi, Kanika Deshpande Koirala, Basudha Khanal, Suman Rijal, Narayan Raj Bhattarai, Thong Phe, Kruy Lim, Deby Mukendi, Jean-Roger Lilo Kalo, Pascal Lutumba, Barbara Barbé, Jan Jacobs, Marjan Van Esbroeck, Nikki Foqué…
    Citation: BMC Medicine 2022 20:144
  34. HER2-low breast cancers were reported to have distinct clinicopathological characteristics from HER2-zero; however, the difference in their genetic features remains unclear. This study investigated the clinica...

    Authors: Guochun Zhang, Chongyang Ren, Cheukfai Li, Yulei Wang, Bo Chen, Lingzhu Wen, Minghan Jia, Kai Li, Hsiaopei Mok, Li Cao, Xiaoqing Chen, Jiali Lin, Guangnan Wei, Yingzhi Li, Yuchen Zhang, Charles M. Balch…
    Citation: BMC Medicine 2022 20:142
  35. Risk genes linked to the development of gout have been identified, and lifestyle factors are related to gout risk. It remains unclear whether healthy lifestyle factors can mitigate the genetic risk of gout. Th...

    Authors: Yuan Zhang, Rongrong Yang, Abigail Dove, Xuerui Li, Hongxi Yang, Shu Li, Ju Wang, Wei-Dong Li, Hongyu Zhao, Weili Xu and Yaogang Wang
    Citation: BMC Medicine 2022 20:138
  36. Individuals with autism spectrum disorder (ASD) are at particularly high risk of suicide and suicide attempts. Presentation to a hospital with self-harm is one of the strongest risk factors for later suicide. ...

    Authors: Emily Widnall, Sophie Epstein, Catherine Polling, Sumithra Velupillai, Amelia Jewell, Rina Dutta, Emily Simonoff, Robert Stewart, Ruth Gilbert, Tamsin Ford, Matthew Hotopf, Richard D. Hayes and Johnny Downs
    Citation: BMC Medicine 2022 20:137
  37. Prenatal maternal tobacco smoking is a predictor of child attention-deficit/hyperactivity disorder (ADHD) and is associated with offspring telomere length (TL). In this study, we examine the relationship betwe...

    Authors: Meghan P. Howell, Christopher W. Jones, Cade A. Herman, Celia V. Mayne, Camilo Fernandez, Katherine P. Theall, Kyle C. Esteves and Stacy S. Drury
    Citation: BMC Medicine 2022 20:153
  38. Preterm birth is defined as live birth before 37 completed weeks of pregnancy, and it is a major problem worldwide. The molecular mechanisms that lead to onset of spontaneous preterm birth are incompletely und...

    Authors: Heli Tiensuu, Antti M. Haapalainen, Pinja Tissarinen, Anu Pasanen, Tomi A. Määttä, Johanna M. Huusko, Steffen Ohlmeier, Ulrich Bergmann, Marja Ojaniemi, Louis J. Muglia, Mikko Hallman and Mika Rämet
    Citation: BMC Medicine 2022 20:141
  39. Ethnic differences in cardiovascular disease (CVD) risk have been known for decades, but a systematic exploration of how exposure and susceptibility to risk factors may contribute is lacking. This study aimed ...

    Authors: Frederick K. Ho, Stuart R. Gray, Paul Welsh, Jason M. R. Gill, Naveed Sattar, Jill P. Pell and Carlos Celis-Morales
    Citation: BMC Medicine 2022 20:149
  40. Poor graft function (PGF) or prolonged isolated thrombocytopenia (PT), which are characterized by pancytopenia or thrombocytopenia, have become serious complications after allogeneic hematopoietic stem cell tr...

    Authors: Yu Wang, Yuan Kong, Hong-Yan Zhao, Yuan-Yuan Zhang, Ya-Zhe Wang, Lan-Ping Xu, Xiao-Hui Zhang, Kai-Yan Liu and Xiao-Jun Huang
    Citation: BMC Medicine 2022 20:140
  41. There is evidence indicating that pesticide exposure is a risk factor for non-Hodgkin lymphoma (NHL) development. However, the association between pesticide exposure and NHL survival is not well-established.

    Authors: Christina Poh, John D. McPherson, Joseph Tuscano, Qian Li, Arti Parikh-Patel, Christoph F. A. Vogel, Myles Cockburn and Theresa Keegan
    Citation: BMC Medicine 2022 20:165
  42. Increasing age, male sex, and pre-existing comorbidities are associated with lower survival from SARS-CoV-2 infection. The interplay between different comorbidities, age, and sex is not fully understood, and i...

    Authors: Nanina Anderegg, Radoslaw Panczak, Matthias Egger, Nicola Low and Julien Riou
    Citation: BMC Medicine 2022 20:164
  43. Family history, and genetic and non-genetic risk factors can stratify women according to their individual risk of developing breast cancer. The extent of overlap between these risk predictors is not clear.

    Authors: Peh Joo Ho, Weang Kee Ho, Alexis J. Khng, Yen Shing Yeoh, Benita Kiat-Tee Tan, Ern Yu Tan, Geok Hoon Lim, Su-Ming Tan, Veronique Kiak Mien Tan, Cheng-Har Yip, Nur-Aishah Mohd-Taib, Fuh Yong Wong, Elaine Hsuen Lim, Joanne Ngeow, Wen Yee Chay, Lester Chee Hao Leong…
    Citation: BMC Medicine 2022 20:150
  44. Triple-negative breast cancer (TNBC) is a biologically diverse disease, with characteristics such as homologous recombination deficiency (HRD), gene mutation, and immune reactions. Japan Breast Cancer Research...

    Authors: Takayuki Ueno, Shigehisa Kitano, Norikazu Masuda, Daiki Ikarashi, Makiko Yamashita, Tomohiro Chiba, Takayuki Kadoya, Hiroko Bando, Takashi Yamanaka, Shoichiro Ohtani, Shigenori Nagai, Takahiro Nakayama, Masato Takahashi, Shigehira Saji, Kenjiro Aogi, Ravi Velaga…
    Citation: BMC Medicine 2022 20:136
  45. Data on the association between free-living daytime sunlight exposure and incident dementia are scarce. The objective is to evaluate whether the time spent in outdoor light is related to the dementia risk and ...

    Authors: Ling-Zhi Ma, Ya-Hui Ma, Ya-Nan Ou, Shi-Dong Chen, Liu Yang, Qiang Dong, Wei Cheng, Lan Tan and Jin-Tai Yu
    Citation: BMC Medicine 2022 20:132