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  1. Application of indocyanine green (ICG) fluorescence imaging is effective in guiding laparoscopic radical lymphadenectomy for gastric cancer. However, the optimal approach for indocyanine green injection is con...

    Authors: Qi-Yue Chen, Qing Zhong, Ping Li, Jian-Wei Xie, Zhi-Yu Liu, Xiao-Bo Huang, Guang-Tan Lin, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Long-Long Cao, Mi Lin, Qiao-Ling Zheng, Ru-Hong Tu, Ze-Ning Huang, Chao-Hui Zheng…

    Citation: BMC Medicine 2021 19:276

    Content type: Research article

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    The Commentary to this article has been published in BMC Medicine 2021 19:272

  2. Adaptive designs offer great promise in improving the efficiency and patient-benefit of clinical trials. An important barrier to further increased use is a lack of understanding about which additional resource...

    Authors: Nina Wilson, Katie Biggs, Sarah Bowden, Julia Brown, Munyaradzi Dimairo, Laura Flight, Jamie Hall, Anna Hockaday, Thomas Jaki, Rachel Lowe, Caroline Murphy, Philip Pallmann, Mark A. Pilling, Claire Snowdon, Matthew R. Sydes, Sofía S. Villar…

    Citation: BMC Medicine 2021 19:251

    Content type: Research article

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  3. Colorectal cancer (CRC) is the leading cause of cancer death worldwide. Screening is a confirmed way to reduce the incidence and mortality rates of CRC. This study aimed to identify a fecal-based, noninvasive,...

    Authors: Lian-Jing Cao, Xiao-Lin Peng, Wen-Qiong Xue, Rong Zhang, Jiang-Bo Zhang, Ting Zhou, Zi-Yi Wu, Gai-Rui Li, Tong-Min Wang, Yong-Qiao He, Da-Wei Yang, Ying Liao, Xia-Ting Tong, Fang Wang, Ke-Xin Chen, Shi-Hong Zhang…

    Citation: BMC Medicine 2021 19:250

    Content type: Research article

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  4. Both genetic and cardiovascular factors contribute to the risk of developing heart failure (HF), but whether idea cardiovascular health metrics (ICVHMs) offset the genetic association with incident HF remains ...

    Authors: Ruotong Yang, Jun Lv, Canqing Yu, Yu Guo, Pei Pei, Ninghao Huang, Ling Yang, Iona Y. Millwood, Robin G. Walters, Yiping Chen, Huaidong Du, Ran Tao, Junshi Chen, Zhengming Chen, Robert Clarke, Tao Huang…

    Citation: BMC Medicine 2021 19:259

    Content type: Research article

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  5. Diabetes mellitus and thyroid disease are two areas of broad interest in the field of endocrinology and metabolism. Variation of thyroid hormone concentration, even within the normal range, may portend the ons...

    Authors: Fen Rong, Hongji Dai, Yuwan Wu, Jibin Li, Guoping Liu, Hanbei Chen and Xi Zhang

    Citation: BMC Medicine 2021 19:257

    Content type: Research article

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  6. Epidemiological studies in atrial fibrillation (AF) illustrate that clinical complexity increase the risk of major adverse outcomes. We aimed to describe European AF patients’ clinical phenotypes and analyse t...

    Authors: Marco Proietti, Marco Vitolo, Stephanie L. Harrison, Deirdre A. Lane, Laurent Fauchier, Francisco Marin, Michael Nabauer, Tatjana S. Potpara, Gheorghe-Andrei Dan, Giuseppe Boriani and Gregory Y. H. Lip

    Citation: BMC Medicine 2021 19:256

    Content type: Research article

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  7. The combination of bevacizumab and epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) could prolong progression-free survival (PFS) in patients with EGFR-mutant advanced non-small-cell lung c...

    Authors: Yongchang Zhang, Liang Zeng, Xiangyu Zhang, Yizhi Li, Lingli Liu, Qinqin Xu, Haiyan Yang, Wenjuan Jiang, Analyn Lizaso, Luting Qiu, Ting Hou, Jun Liu, Ling Peng and Nong Yang

    Citation: BMC Medicine 2021 19:245

    Content type: Research article

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  8. The BNT162b2 mRNA vaccine has been shown to be effective at preventing serious COVID-19 events in clinical trials. There is less evidence on effectiveness in real-world settings, especially for older people. H...

    Authors: Thomas F. D. Mason, Matt Whitston, Jack Hodgson, Ruth E. Watkinson, Yiu-Shing Lau, Omnia Abdulrazeg and Matt Sutton

    Citation: BMC Medicine 2021 19:275

    Content type: Research article

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  9. Frailty has been identified as a risk factor for cognitive impairment and dementia. However, it is not known whether familial factors, such as genetics and shared environmental factors, underlie this associati...

    Authors: Ge Bai, Yunzhang Wang, Ralf Kuja-Halkola, Xia Li, Yasutake Tomata, Ida K. Karlsson, Nancy L. Pedersen, Sara Hägg and Juulia Jylhävä

    Citation: BMC Medicine 2021 19:248

    Content type: Research article

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  10. We and others have confirmed activation of macrophages plays a critical role in liver injury and fibrogenesis during HBV infection. And we have also proved HBeAg can obviously induce the production of macropha...

    Authors: Xiaoyu Xie, Huanran Lv, Chenxi Liu, Xiaonan Su, Zhen Yu, Shouyang Song, Hongjun Bian, Miaomiao Tian, Chengyong Qin, Jianni Qi and Qiang Zhu

    Citation: BMC Medicine 2021 19:247

    Content type: Research article

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  11. The effect of contact reduction measures on infectious disease transmission can only be assessed indirectly and with considerable delay. However, individual social contact data and population mobility data can...

    Authors: Damilola Victoria Tomori, Nicole Rübsamen, Tom Berger, Stefan Scholz, Jasmin Walde, Ian Wittenberg, Berit Lange, Alexander Kuhlmann, Johannes Horn, Rafael Mikolajczyk, Veronika K. Jaeger and André Karch

    Citation: BMC Medicine 2021 19:271

    Content type: Research article

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  12. In a prospective healthcare worker (HCW) cohort, we assessed the risk of SARS-CoV-2 infection according to baseline serostatus.

    Authors: Philipp Kohler, Sabine Güsewell, Marco Seneghini, Thomas Egger, Onicio Leal, Angela Brucher, Eva Lemmenmeier, J. Carsten Möller, Philip Rieder, Markus Ruetti, Reto Stocker, Danielle Vuichard-Gysin, Benedikt Wiggli, Ulrike Besold, Stefan P. Kuster, Allison McGeer…

    Citation: BMC Medicine 2021 19:270

    Content type: Research article

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  13. Global progress towards reducing tuberculosis (TB) incidence and mortality has consistently lagged behind the World Health Organization targets leading to a perception that large reductions in TB burden cannot...

    Authors: Sourya Shrestha, Emily A. Kendall, Rebekah Chang, Roy Joseph, Parastu Kasaie, Laura Gillini, Anthony Todd Fojo, Michael Campbell, Nimalan Arinaminpathy and David W. Dowdy

    Citation: BMC Medicine 2021 19:244

    Content type: Research article

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  14. Plasma cell-free DNA (cfDNA) methylation has shown promising results in the early detection of multiple cancers recently. Here, we conducted a study to investigate the performance of cfDNA methylation in the e...

    Authors: Guibin Qiao, Weitao Zhuang, Bo Dong, Chengcheng Li, Jiayue Xu, Guoqiang Wang, Liang Xie, Zihao Zhou, Dan Tian, Gang Chen, Jiming Tang, Haiyu Zhou, Dongkun Zhang, Ruiqing Shi, Rixin Chen, Weiqi Nian…

    Citation: BMC Medicine 2021 19:243

    Content type: Research article

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  15. Chronic stress increases chronic disease risk and may underlie the association between exposure to adverse socioeconomic conditions and adverse health outcomes. The relationship between exposure to such condit...

    Authors: Loes Crielaard, Mary Nicolaou, Alexia Sawyer, Rick Quax and Karien Stronks

    Citation: BMC Medicine 2021 19:242

    Content type: Research article

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  16. A greater understanding of the factors that are associated with favourable health may help increase longevity and healthy life expectancy. We examined sociodemographic, psychosocial, lifestyle and environmenta...

    Authors: Julian Mutz, Charlotte J. Roscoe and Cathryn M. Lewis

    Citation: BMC Medicine 2021 19:240

    Content type: Research article

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  17. Women with a history of gestational diabetes mellitus (GDM) have a 7-fold higher risk of developing type 2 diabetes (T2D). It is estimated that 20-50% of women with GDM history will progress to T2D within 10 y...

    Authors: Ziyi Zhang, Mi Lai, Anthony L. Piro, Stacey E. Alexeeff, Amina Allalou, Hannes L. Röst, Feihan F. Dai, Michael B. Wheeler and Erica P. Gunderson

    Citation: BMC Medicine 2021 19:241

    Content type: Research article

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  18. With the revolutionary progress of immune checkpoint inhibitors (ICIs) achieved in non-small cell lung cancers (NSCLC), identifying patients benefiting from ICIs becomes critical and urgent. The associations o...

    Authors: Yiting Sun, Jianchun Duan, Wenfeng Fang, Zhijie Wang, Xinyang Du, Xin Wang, Chengcheng Li, Shangli Cai, Jie Zhao, Sini Li, Li Zhang, Hua Bai and Jie Wang

    Citation: BMC Medicine 2021 19:239

    Content type: Research article

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  19. The diagnosis of coeliac disease (CD) in individuals that have started a gluten-free diet (GFD) without an adequate previous diagnostic work-out is a challenge. Several immunological assays such as IFN-γ ELISP...

    Authors: Fernando Fernández-Bañares, Natalia López-Palacios, María Corzo, Beatriz Arau, Mercedes Rubio, Marta Fernández-Prieto, Eva Tristán, Mar Pujals, Sergio Farrais, Saúl Horta, Juana María Hernández, Marta Gomez-Perosanz, Pedro A. Reche, María Esteve and Concepción Núñez

    Citation: BMC Medicine 2021 19:237

    Content type: Research article

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  20. Iron deficiency (ID) has been associated with adverse pregnancy outcomes, maternal anaemia, and altered susceptibility to infection. In Papua New Guinea (PNG), monthly treatment with sulphadoxine-pyrimethamine...

    Authors: Holger W. Unger, Valentina Laurita Longo, Andie Bleicher, Maria Ome-Kaius, Stephan Karl, Julie A. Simpson, Amalia Karahalios, Elizabeth H. Aitken and Stephen J. Rogerson

    Citation: BMC Medicine 2021 19:236

    Content type: Research article

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  21. This study aims to identify the causative strain of SARS-CoV-2 in a cluster of vaccine breakthroughs. Vaccine breakthrough by a highly transmissible SARS-CoV-2 strain is a risk to global public health.

    Authors: Timothy Farinholt, Harsha Doddapaneni, Xiang Qin, Vipin Menon, Qingchang Meng, Ginger Metcalf, Hsu Chao, Marie-Claude Gingras, Vasanthi Avadhanula, Paige Farinholt, Charu Agrawal, Donna M. Muzny, Pedro A. Piedra, Richard A. Gibbs and Joseph Petrosino

    Citation: BMC Medicine 2021 19:255

    Content type: Research article

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  22. With the identification of new targetable drivers and the recent emergence of novel targeted drugs, using comprehensive genomic profiling in lieu of the routine testing for classic drivers in the clinical care...

    Authors: Shen Zhao, Zhonghan Zhang, Jianhua Zhan, Xin Zhao, Xinru Chen, Liyun Xiao, Kui Wu, Yuxiang Ma, Mengzhen Li, Yunpeng Yang, Wenfeng Fang, Hongyun Zhao and Li Zhang

    Citation: BMC Medicine 2021 19:223

    Content type: Research article

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  23. To investigate how socioeconomic position (SEP) influences the effectiveness of cancer-directed treatment in premenopausal breast cancer patients in terms of breast cancer recurrence and mortality.

    Authors: Cathrine Fonnesbech Hjorth, Per Damkier, Bent Ejlertsen, Timothy Lash, Henrik Toft Sørensen and Deirdre Cronin-Fenton

    Citation: BMC Medicine 2021 19:235

    Content type: Research article

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  24. Stratifying dengue risk within endemic countries is crucial for allocating limited control interventions. Current methods of monitoring dengue transmission intensity rely on potentially inaccurate incidence es...

    Authors: Joseph R. Biggs, Ava Kristy Sy, Katharine Sherratt, Oliver J. Brady, Adam J. Kucharski, Sebastian Funk, Mary Anne Joy Reyes, Mary Ann Quinones, William Jones-Warner, Ferchito L. Avelino, Nemia L. Sucaldito, Amado O. Tandoc, Eva Cutiongco-de la Paz, Maria Rosario Z. Capeding, Carmencita D. Padilla, Julius Clemence R. Hafalla…

    Citation: BMC Medicine 2021 19:217

    Content type: Research article

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  25. SARS-CoV-2 dynamics are driven by human behaviour. Social contact data are of utmost importance in the context of transmission models of close-contact infections.

    Authors: Frederik Verelst, Lisa Hermans, Sarah Vercruysse, Amy Gimma, Pietro Coletti, Jantien A. Backer, Kerry L. M. Wong, James Wambua, Kevin van Zandvoort, Lander Willem, Laurens Bogaardt, Christel Faes, Christopher I. Jarvis, Jacco Wallinga, W. John Edmunds, Philippe Beutels…

    Citation: BMC Medicine 2021 19:254

    Content type: Database

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  26. Excessive sodium consumption is one of the leading dietary risk factors for non-communicable diseases, including cardiovascular disease (CVD), mediated by high blood pressure. Brazil has implemented voluntary ...

    Authors: Eduardo Augusto Fernandes Nilson, Jonathan Pearson-Stuttard, Brendan Collins, Maria Guzman-Castillo, Simon Capewell, Martin O’Flaherty, Patrícia Constante Jaime and Chris Kypridemos

    Citation: BMC Medicine 2021 19:225

    Content type: Research article

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  27. Multimorbidity is prevalent for people with myocardial infarction (MI), yet previous studies investigated single-health conditions in isolation. We identified patterns of multimorbidity in MI survivors and the...

    Authors: T. Munyombwe, T. B. Dondo, S. Aktaa, C. Wilkinson, M. Hall, B. Hurdus, G. Oliver, R. M. West, A. S. Hall and C. P. Gale

    Citation: BMC Medicine 2021 19:227

    Content type: Research article

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  28. For some SARS-CoV-2 survivors, recovery from the acute phase of the infection has been grueling with lingering effects. Many of the symptoms characterized as the post-acute sequelae of COVID-19 (PASC) could ha...

    Authors: Hossein Estiri, Zachary H. Strasser, Gabriel A. Brat, Yevgeniy R. Semenov, Chirag J. Patel and Shawn N. Murphy

    Citation: BMC Medicine 2021 19:249

    Content type: Research article

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  29. There is an evidence gap about whether levels of engagement with public services such as schools and health care affect people across the lifespan. Data on missed patient appointments from a nationally represe...

    Authors: Ross McQueenie, David A. Ellis, Michael Fleming, Philip Wilson and Andrea E. Williamson

    Citation: BMC Medicine 2021 19:219

    Content type: Research article

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  30. A ‘shadow pandemic’ of domestic violence and abuse (DVA) has emerged secondary to strict public health measures containing the spread of SARS-CoV-2. Many countries have implemented policies to allow the free m...

    Authors: Joht Singh Chandan, Anuradhaa Subramanian, Jaidev Kaur Chandan, Krishna M. Gokhale, Alecs Vitoc, Julie Taylor, Caroline Bradbury-Jones, Siddhartha Bandyopadhyay and Krishnarajah Nirantharakumar

    Citation: BMC Medicine 2021 19:246

    Content type: Correspondence

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  31. Both genetic and pre- and perinatal factors, including birth weight, have been implicated in the onset of attention deficit hyperactivity disorder (ADHD) traits among children. This study aimed to elucidate to...

    Authors: Md Shafiur Rahman, Nagahide Takahashi, Toshiki Iwabuchi, Tomoko Nishimura, Taeko Harada, Akemi Okumura, Nori Takei, Yoko Nomura and Kenji J. Tsuchiya

    Citation: BMC Medicine 2021 19:229

    Content type: Research article

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  32. The information given to people considering taking part in a trial needs to be easy to understand if those people are to become, and then remain, trial participants. However, there is a tension between providi...

    Authors: Vichithranie W. Madurasinghe, Peter Bower, Sandra Eldridge, David Collier, Jonathan Graffy, Shaun Treweek, Peter Knapp, Adwoa Parker, Jo Rick, Chris Salisbury, Mei See Man, David Torgerson, Rebecca Sheridan, Frank Sullivan, Sarah Cockayne and Charlotte Dack

    Citation: BMC Medicine 2021 19:218

    Content type: Research article

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  33. This is the first study to investigate the effect of parental psychological abuse on potential psychopathological symptoms in gender minority youth subgroups, including transgender women, transgender men, and ...

    Authors: Yuanyuan Wang, Zhihao Ma, Amanda Wilson, Zhishan Hu, Xin Ying, Meng Han, Zaixu Cui and Runsen Chen

    Citation: BMC Medicine 2021 19:215

    Content type: Research article

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  34. Health system financing presents a challenge in many developing countries. We assessed two reform packages, performance-based financing (PBF) and direct facility financing (DFF), against each other and busines...

    Authors: Madhulika Khanna, Benjamin Loevinsohn, Elina Pradhan, Opeyemi Fadeyibi, Kevin McGee, Oluwole Odutolu, Gyorgy Bela Fritsche, Emmanuel Meribole, Christel M. J. Vermeersch and Eeshani Kandpal

    Citation: BMC Medicine 2021 19:224

    Content type: Research article

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  35. Despite adherence to WHO guidelines, inpatient mortality among sick children admitted to hospital with complicated severe acute malnutrition (SAM) remains unacceptably high. Several studies have examined risk ...

    Authors: Bijun Wen, Daniella Brals, Celine Bourdon, Lauren Erdman, Moses Ngari, Emmanuel Chimwezi, Isabel Potani, Johnstone Thitiri, Laura Mwalekwa, James A. Berkley, Robert H. J. Bandsma and Wieger Voskuijl

    Citation: BMC Medicine 2021 19:222

    Content type: Research article

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  36. Alcohol consumption is an important risk factor for hepatic neoplastic and non-neoplastic diseases. Questions remain, however, about the relevance to disease risk of drinking patterns and alcohol tolerability,...

    Authors: Pek Kei Im, Iona Y. Millwood, Christiana Kartsonaki, Yu Guo, Yiping Chen, Iain Turnbull, Canqing Yu, Huaidong Du, Pei Pei, Jun Lv, Robin G. Walters, Liming Li, Ling Yang and Zhengming Chen

    Citation: BMC Medicine 2021 19:216

    Content type: Research article

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  37. Studies on allergy-related diseases in relation to abdominal pain-related functional gastrointestinal disorders (AP-FGIDs) in children are few and results are contradictory. We examined the associations betwee...

    Authors: Jessica Sjölund, Inger Kull, Anna Bergström, Jacob Järås, Jonas F. Ludvigsson, Hans Törnblom, Magnus Simrén and Ola Olén

    Citation: BMC Medicine 2021 19:214

    Content type: Research article

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  38. Significant improvements in mortality among patients with non-small cell lung cancer (NSCLC) in the USA over the past two decades have been reported based on Surveillance, Epidemiology, and End Results (SEER) ...

    Authors: Sreeram Ramagopalan, Thomas P. Leahy, Joshua Ray, Samantha Wilkinson, Cormac Sammon and Vivek Subbiah

    Citation: BMC Medicine 2021 19:209

    Content type: Research article

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  39. ROS1-rearranged lung cancers benefit from first-line crizotinib therapy; however, clinical and molecular factors that could affect crizotinib efficacy in ROS1-rearranged lung cancers are not yet well-elucidated. ...

    Authors: Yongchang Zhang, Xiangyu Zhang, Ruiguang Zhang, Qinqin Xu, Haiyan Yang, Analyn Lizaso, Chunwei Xu, Jun Liu, Wenxian Wang, Sai-Hong Ignatius Ou, Jiexia Zhang, Zhengbo Song and Nong Yang

    Citation: BMC Medicine 2021 19:206

    Content type: Research article

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  40. Schools were closed in England on 4 January 2021 as part of increased national restrictions to curb transmission of SARS-CoV-2. The UK government reopened schools on 8 March. Although there was evidence of low...

    Authors: James D. Munday, Christopher I. Jarvis, Amy Gimma, Kerry L. M. Wong, Kevin van Zandvoort, Sebastian Funk and W. John Edmunds

    Citation: BMC Medicine 2021 19:233

    Content type: Research article

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  41. Genetic, lifestyle, and environmental factors can lead to perturbations in circulating lipid levels and increase the risk of cardiovascular and metabolic diseases. However, how changes in individual lipid spec...

    Authors: Eric L. Harshfield, Eric B. Fauman, David Stacey, Dirk S. Paul, Daniel Ziemek, Rachel M. Y. Ong, John Danesh, Adam S. Butterworth, Asif Rasheed, Taniya Sattar, Zameer-ul-Asar, Imran Saleem, Zoubia Hina, Unzila Ishtiaq, Nadeem Qamar, Nadeem Hayat Mallick…

    Citation: BMC Medicine 2021 19:232

    Content type: Research article

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  42. Integration of health services might be an efficient strategy for managing multiple chronic conditions in sub-Saharan Africa, considering the scope of treatments and synergies in service delivery. Proven to pr...

    Authors: Tinevimbo Shiri, Josephine Birungi, Anupam V. Garrib, Sokoine L. Kivuyo, Ivan Namakoola, Janneth Mghamba, Joshua Musinguzi, Godfather Kimaro, Gerald Mutungi, Moffat J. Nyirenda, Joseph Okebe, Kaushik Ramaiya, M. Bachmann, Nelson K. Sewankambo, Sayoki Mfinanga, Shabbar Jaffar…

    Citation: BMC Medicine 2021 19:230

    Content type: Research article

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  43. Healthy individuals and patients with cancer who are carriers of germline pathogenic variants in the BRCA1/2 genes face multiple reproductive challenges that require appropriate counseling and specific expertise.

    Authors: Barbara Buonomo, Claudia Massarotti, Miriam Dellino, Paola Anserini, Alberta Ferrari, Maria Campanella, Mirosa Magnotti, Cristofaro De Stefano, Fedro Alessandro Peccatori and Matteo Lambertini

    Citation: BMC Medicine 2021 19:205

    Content type: Correspondence

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  44. The sustainable development goals aim to improve health for all by 2030. They incorporate ambitious goals regarding tuberculosis (TB), which may be a significant cause of disability, yet to be quantified. Ther...

    Authors: Kefyalew Addis Alene, Kinley Wangdi, Samantha Colquhoun, Kudakwashe Chani, Tauhid Islam, Kalpeshsinh Rahevar, Fukushi Morishita, Anthony Byrne, Justin Clark and Kerri Viney

    Citation: BMC Medicine 2021 19:203

    Content type: Research article

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