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  1. This study is to propose a clinically applicable 2-echelon (2e) diagnostic criteria for the analysis of thyroid nodules such that low-risk nodules are screened off while only suspicious or indeterminate ones a...

    Authors: Dong Xu, Lin Sui, Chunquan Zhang, Jing Xiong, Vicky Yang Wang, Yahan Zhou, Xinying Zhu, Chen Chen, Yu Zhao, Yiting Xie, Weizhen Kong, Jincao Yao, Lei Xu, Yuxia Zhai and Liping Wang
    Citation: BMC Medicine 2024 22:293
  2. Authors: Fang-Hua Liu, Jia-Kai Guo, Wei-Yi Xing, Xue-Li Bai, Yu-Jiao Chang, Zhao Lu, Miao Yang, Ying Yang, Wen-Jing Li, Xian-Xian Jia, Tao Zhang, Jing Yang, Jun-Tong Chen, Song Gao, Lang Wu, De-Yu Zhang…
    Citation: BMC Medicine 2024 22:291

    The original article was published in BMC Medicine 2024 22:206

  3. Epigenetic clocks were known as promising biomarkers of aging, including original clocks trained by individual CpG sites and principal component (PC) clocks trained by PCs of CpG sites. The effects of genetic ...

    Authors: Ke Miao, Shunkai Liu, Weihua Cao, Jun Lv, Canqing Yu, Tao Huang, Dianjianyi Sun, Chunxiao Liao, Yuanjie Pang, Runhua Hu, Zengchang Pang, Min Yu, Hua Wang, Xianping Wu, Yu Liu, Wenjing Gao…
    Citation: BMC Medicine 2024 22:289
  4. Ethnicity is known to be an important correlate of health outcomes, particularly during the COVID-19 pandemic, where some ethnic groups were shown to be at higher risk of infection and adverse outcomes. The re...

    Authors: Colm D. Andrews, Rohini Mathur, Jon Massey, Robin Park, Helen J. Curtis, Lisa Hopcroft, Amir Mehrkar, Seb Bacon, George Hickman, Rebecca Smith, David Evans, Tom Ward, Simon Davy, Peter Inglesby, Iain Dillingham, Steven Maude…
    Citation: BMC Medicine 2024 22:288
  5. Despite the many benefits of school meals, not all students participate. One reason students may not participate in school meals is because they instead purchase breakfast or lunch from food outlets located ar...

    Authors: Emily M. Melnick, Francesco Acciai, Michael J. Yedidia and Punam Ohri-Vachaspati
    Citation: BMC Medicine 2024 22:287
  6. Advanced practice providers (APPs), including physician assistants/associates (PAs), nurse practitioners (NPs) and other non-physician roles, have been developed largely to meet changing healthcare demand and ...

    Authors: Yingxi Zhao, Wesley Quadros, Shobhana Nagraj, Geoff Wong, Mike English and Attakrit Leckcivilize
    Citation: BMC Medicine 2024 22:286
  7. This study employs systematic review and meta-analysis to explore the incidence and characteristics of spinal cord injury (SCI) between 2000 and 2021, aiming to provide the most recent and comprehensive data s...

    Authors: Yubao Lu, Zhizhong Shang, Wei Zhang, Mao Pang, Xuchang Hu, Yu Dai, Ruoqi Shen, Yingjie Wu, Chenrui Liu, Ting Luo, Xin Wang, Bin Liu, Liangming Zhang and Limin Rong
    Citation: BMC Medicine 2024 22:285
  8. Infant neurodevelopment in the first years after birth is determined by multiple factors, including parental care and maternal mental wellbeing. In this study, we aim to assess the impact of persistent materna...

    Authors: Ashish KC, Jaya Chandna, Ankit Acharya, Rejina Gurung, Carin Andrew and Alkistis Skalkidou
    Citation: BMC Medicine 2024 22:284
  9. Chronic pelvic pain (CPP) is a multifactorial syndrome that can substantially affect a patient’s quality of life. Endometriosis is one cause of CPP, and alterations of the immune and microbiome profiles have b...

    Authors: Nicole Jimenez, Taylor Norton, Gurbeen Diadala, Emerald Bell, Michelle Valenti, Leslie V. Farland, Nichole Mahnert and Melissa M. Herbst-Kralovetz
    Citation: BMC Medicine 2024 22:283
  10. The advances in deep learning-based pathological image analysis have invoked tremendous insights into cancer prognostication. Still, lack of interpretability remains a significant barrier to clinical application.

    Authors: Guang-Yu Ding, Wei-Min Tan, You-Pei Lin, Yu Ling, Wen Huang, Shu Zhang, Jie-Yi Shi, Rong-Kui Luo, Yuan Ji, Xiao-Ying Wang, Jian Zhou, Jia Fan, Mu-Yan Cai, Bo Yan and Qiang Gao
    Citation: BMC Medicine 2024 22:282
  11. The increase in population aging highlights the growing prevalence of mild cognitive impairment, prompting the adoption of interventions that combine physical exercise and cognitive training to improve health ...

    Authors: Yolanda Castellote-Caballero, María del Carmen Carcelén Fraile, Agustín Aibar-Almazán, Diego Fernando Afanador-Restrepo and Ana María González-Martín
    Citation: BMC Medicine 2024 22:281
  12. Social prescribing is gaining traction internationally. It is an approach which seeks to address non-medical and health-related social needs through taking a holistic person-centred and community-based approac...

    Authors: Amadea Turk, Stephanie Tierney, Bernie Hogan, Kamal R. Mahtani and Catherine Pope
    Citation: BMC Medicine 2024 22:280
  13. APRI and FIB-4 scores are used to exclude clinically significant fibrosis (defined as stage ≥ F2) in patients with chronic viral hepatitis. However, the cut-offs for these scores (generated by Youden indices) ...

    Authors: Lumin Yang, Yafei Zhang, Xiaodan Hong, Ke Zhang, Bingyan Liu, Peixin Zhang, Qianqian Tang, Jian Yu, Xiao-Zhi Jin, Xin-Zhe Jin, Ni Zhang, Giovanni Targher, Christopher D. Byrne, Zhenhua Zhang, Ming-Hua Zheng and Jinsong Zhang
    Citation: BMC Medicine 2024 22:278
  14. With the global challenge of antimicrobial resistance intensified during the COVID-19 pandemic, evaluating adverse events (AEs) post-antibiotic treatment for common infections is crucial. This study aims to ex...

    Authors: Xiaomin Zhong, Victoria Palin, Darren M. Ashcroft, Ben Goldacre, Brian MacKenna, Amir Mehrkar, Sebastian C. J. Bacon, Jon Massey, Peter Inglesby, Kieran Hand, Alexander Pate and Tjeerd Pieter van Staa
    Citation: BMC Medicine 2024 22:277
  15. Pregnancy acts as a cardiovascular stress test. Although many complications resolve following birth, women with hypertensive disorder of pregnancy have an increased risk of developing cardiovascular disease (C...

    Authors: Siobhán O’Connor, George Tilston, Olivia Jones, Anita Sharma, Laura Ormesher, Bradley Quinn, Anthony Wilson, Jenny Myers, Niels Peek and Victoria Palin
    Citation: BMC Medicine 2024 22:276
  16. Ethnic inequalities in acute health acute care are not well researched. We examined how attendee ethnicity influenced outcomes of emergency care in unselected patients presenting with a gastrointestinal (GI) d...

    Authors: Christopher A. Martin, Tim Coats, Manish Pareek, Kamlesh Khunti, Ruw Abeyratne and Nigel J. Brunskill
    Citation: BMC Medicine 2024 22:275
  17. The COVID-19 pandemic has had a significant impact on mental health, with evidence suggesting an enduring mental health crisis. Studies worldwide observed increased usage of antidepressants, anxiolytics, and h...

    Authors: Antoine Lamer, Chloé Saint-Dizier, Mathieu Levaillant, Jean-François Hamel-Broza, Eiya Ayed, Emmanuel Chazard, Maxime Bubrovszky, Fabien D’Hondt, Michael Génin and Mathilde Horn
    Citation: BMC Medicine 2024 22:274
  18. Renal outcomes in patients with type 2 diabetes following treatment with sodium–glucose co-transporter-2 inhibitors (SGLT2is) or glucagon-like peptide-1 receptor agonists (GLP1RAs) have not been directly compa...

    Authors: Minji Sohn, Seoungyeon Nam, Michael A. Nauck and Soo Lim
    Citation: BMC Medicine 2024 22:273
  19. Benzodiazepine use is common, particularly in older adults. Benzodiazepines have well-established acute adverse effects on cognition, but long-term effects on neurodegeneration and dementia risk remain uncertain.

    Authors: Ilse vom Hofe, Bruno H. Stricker, Meike W. Vernooij, M. Kamran Ikram, M. Arfan Ikram and Frank J. Wolters
    Citation: BMC Medicine 2024 22:266
  20. Non-pharmacological interventions have a myriad of available intervention options and contain multiple components. Whether specific components of non-pharmacological interventions or combinations are superior ...

    Authors: Xiao-Hong Yu, Xin-Ru Li, Zhi-Run Du, Yu Zhang, Yang Fei, Wen-Ping Tang, Xian-Wen Li and Qing Zhao
    Citation: BMC Medicine 2024 22:272
  21. To evaluate the neurological alterations induced by Omicron infection, to compare brain changes in chronic insomnia with those in exacerbated chronic insomnia in Omicron patients, and to examine individuals wi...

    Authors: Yanyao Du, Cong Li, Wei Zhao, Jinyue Li, Linlin Zhao, Huili Guo, Yingjia Jiang, Weiyin Vivian Liu, Song Zeng, Huiting Zhang, Hu Guo, Xuan Ouyang and Jun Liu
    Citation: BMC Medicine 2024 22:271
  22. Previous studies, including Mendelian randomization (MR), have demonstrated type 2 diabetes (T2D) and glycemic traits are associated with increased risk of metabolic dysfunction-associated steatotic liver dise...

    Authors: Ying Liang, Shan Luo, Steven Bell, Jacky Man Yuen Mo, Baoting He, Yangzhong Zhou, Xiaoyin Bai and Shiu Lun Au Yeung
    Citation: BMC Medicine 2024 22:270
  23. In the USA, the prolonged effective survival of cancer population has brought significant attention to the rising risk of cardiometabolic morbidity and mortality in this population. This heightened risk unders...

    Authors: Yukun Li, Xiaoying Liu, Wenhe Lv, Xuesi Wang, Zhuohang Du, Xinmeng Liu, Fanchao Meng, Shuqi Jin, Songnan Wen, Rong Bai, Nian Liu and Ribo Tang
    Citation: BMC Medicine 2024 22:269
  24. Interest in modifiable risk factors (MRFs) for dementia is high, given the personal, social, and economic impact of the disorder, especially in ageing societies such as the United Kingdom. Exploring the popula...

    Authors: Shanquan Chen, Benjamin R. Underwood, Rudolf N. Cardinal, Xi Chen, Shu Chen, Jay Amin, Huajie Jin, Jing Huang, Christoph Mueller, Lijing L. Yan, Carol Brayne and Hannah Kuper
    Citation: BMC Medicine 2024 22:268
  25. Evidence from observational studies indicates that lung cancer screening (LCS) guidelines with high rates of lung cancer (LC) underdiagnosis, and although current screening guidelines have been updated and eli...

    Authors: Yanyan Tang, Lina Zhou, Fei Wang, Yao Huang, Jianwei Wang, Shijun Zhao, Linlin Qi, Li Liu, Min Liang, Donghui Hou, Zhijian Xu, Kai Zhang, Wei Tang and Ning Wu
    Citation: BMC Medicine 2024 22:267
  26. People with different types of dementia may have distinct symptoms and experiences that affect their quality of life. This study investigated whether quality of life varied across types of dementia and over time.

    Authors: Anthony Martyr, Laura D. Gamble, Anna Hunt, Catherine Quinn, Robin G. Morris, Catherine Henderson, Louise Allan, Carol Opdebeeck, Catherine Charlwood, Roy W. Jones, Claire Pentecost, Michael D. Kopelman, Jeanette M. Thom, Fiona E. Matthews and Linda Clare
    Citation: BMC Medicine 2024 22:265
  27. Ureteral cancer is a rare cancer. This study aimed to provide an up-to-date and comprehensive analysis on the global trends of ureteral cancer incidence and its association with lifestyle and metabolic risk fa...

    Authors: Junjie Huang, Wing Sze Pang, Yat Ching Fung, Fung Yu Mak, Sze Chai Chan, Xianjing Liu, Lin Zhang, Don Eliseo Lucero-Prisno III, Wanghong Xu, Zhi-Jie Zheng, Marco Moschini, Benjamin Pradere, Francesco Soria, Dmitry Enikeev, Morgan Roupret, Shahrokh Shariat…
    Citation: BMC Medicine 2024 22:264
  28. To combat coronavirus disease 2019 (COVID-19), booster vaccination strategies are important. However, the optimal administration of booster vaccine platforms remains unclear. Herein, we aimed to assess the ben...

    Authors: Mark Aninakwah Asante, Martin Ekholm Michelsen, Mithuna Mille Balakumar, Buddheera Kumburegama, Amin Sharifan, Allan Randrup Thomsen, Steven Kwasi Korang, Christian Gluud and Sonia Menon
    Citation: BMC Medicine 2024 22:263
  29. To assess the largely undetermined separate and joint effects of sleep and liver function biomarkers on liver cancer.

    Authors: Jiahao Song, Lieyang Fan, Da Shi, Xuefeng Lai, Hao Wang, Wei Liu, Linling Yu, Ruyi Liang, Yongfang Zhang, Shuhui Wan, Yueru Yang and Bin Wang
    Citation: BMC Medicine 2024 22:261
  30. The cancer experienced in adolescent and young adult (AYA) could disturb developmental changes and long-term life. The current AYA guidelines and research for survivorship were developed and reported according...

    Authors: Sooyeon Kim, Dong Wook Shin, Su-Min Jeong, Danbee Kang and Juhee Cho
    Citation: BMC Medicine 2024 22:260
  31. IMCY-0098, a synthetic peptide developed to halt disease progression via elimination of key immune cells in the autoimmune cascade, has shown a promising safety profile for the treatment of type 1 diabetes (T1...

    Authors: Jean Van Rampelbergh, Peter Achenbach, Richard David Leslie, Martin Kindermans, Frédéric Parmentier, Vincent Carlier, Nicolas Bovy, Luc Vanderelst, Marcelle Van Mechelen, Pierre Vandepapelière and Christian Boitard
    Citation: BMC Medicine 2024 22:259
  32. The 2018/2023 ESC/ESH Guidelines underlined a gap how baseline cardiovascular disease (CVD) risk predicted blood pressure (BP) lowering benefits. Further, 2017 ACC/AHA Guideline and 2021 WHO Guideline recommen...

    Authors: Guozhe Sun, Chang Wang, Ning Ye, Chuning Shi, Nanxiang Ouyang, Lixia Qiao, Guangxiao Li, Linlin Zhang, Yao Yu, Zhi Li, Ying Zhou, Zihan Chen, Shu Zhang, Pengyu Zhang, Danxi Geng, Wei Miao…
    Citation: BMC Medicine 2024 22:258
  33. The relationship between variation in serum uric acid (SUA) levels and brain health is largely unknown. This study aimed to examine the associations of long-term variability in SUA levels with neuroimaging met...

    Authors: Han Lv, Jing Sun, Tong Zhang, Ying Hui, Jing Li, Xinyu Zhao, Shuohua Chen, Wenjuan Liu, Xiaoshuai Li, Pengfei Zhao, Shouling Wu, Yanying Liu and Zhenchang Wang
    Citation: BMC Medicine 2024 22:256
  34. Long COVID potentially increases healthcare utilisation and costs. However, its impact on the NHS remains to be determined.

    Authors: Liang-Yu Lin, Alasdair D. Henderson, Oliver Carlile, Iain Dillingham, Ben F. C. Butler-Cole, Michael Marks, Andrew Briggs, Mark Jit, Laurie A. Tomlinson, Chris Bates, John Parry, Sebastian C. J. Bacon, Ben Goldacre, Amir Mehrkar, Brian MacKenna, Rosalind M. Eggo…
    Citation: BMC Medicine 2024 22:255
  35. Alzheimer’s disease (AD) is a neurodegenerative disease characterized by Aβ plaques and neurofibrillary tangles. Chronic inflammation and synaptic dysfunction lead to disease progression and cognitive decline....

    Authors: Rishabh Singh, Sanskriti Rai, Prahalad Singh Bharti, Sadaqa Zehra, Priya Kumari Gorai, Gyan Prakash Modi, Neerja Rani, Kapil Dev, Krishna Kishore Inampudi, Vishnu V. Y., Prasun Chatterjee, Fredrik Nikolajeff and Saroj Kumar
    Citation: BMC Medicine 2024 22:254
  36. Cognitive dysfunction is one of the common symptoms in patients with major depressive disorder (MDD). Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) have...

    Authors: Xingxing Li, Junyao Liu, Shuochi Wei, Chang Yu, Dongmei Wang, Yuchen Li, Jiaxin Li, Wenhao Zhuang, Rui-Chen-Xi Luo, Yanli Li, Zhiwang Liu, Yuqiu Su, Jimeng Liu, Yongming Xu, Jialin Fan, Guidong Zhu…
    Citation: BMC Medicine 2024 22:253
  37. Previous studies have shown that the addition of platinum to neoadjuvant chemotherapy (NAC) improved outcomes for patients with triple-negative breast cancer (TNBC). However, no studies have assessed the effic...

    Authors: Cheng Wang, Long Yuan, Xiujuan Wu, Yan Wang, Hao Tian, Guozhi Zhang, Andi Wan, Siyi Xiong, Chengfang Wang, Yuqin Zhou, Dandan Ma, Yangqiu Bao, Man Qu, Jun Jiang, Yi Zhang and Xiaowei Qi
    Citation: BMC Medicine 2024 22:252
  38. We investigated the association between exercise habits before or after thyroidectomy and incident type 2 diabetes mellitus (T2DM) in patients with thyroid cancer.

    Authors: Jiyun Park, Jin-Hyung Jung, Hyunju Park, Young Shin Song, Soo-Kyung Kim, Yong-Wook Cho, Kyungdo Han and Kyung-Soo Kim
    Citation: BMC Medicine 2024 22:251
  39. The global population of adults aged 60 and above surpassed 1 billion in 2020, constituting 13.5% of the global populace. Projections indicate a rise to 2.1 billion by 2050. While Hospital-at-Home (HaH) progra...

    Authors: Lulu Lin, Mengyuan Cheng, Yawei Guo, Xiaowen Cao, Weiming Tang, Xin Xu, Weibin Cheng and Zhongzhi Xu
    Citation: BMC Medicine 2024 22:250
  40. Residing in a disadvantaged neighborhood has been linked to increased mortality. However, the impact of residential segregation and social vulnerability on cause-specific mortality is understudied. Additionall...

    Authors: Kui Deng, Meng Xu, Melis Sahinoz, Qiuyin Cai, Martha J. Shrubsole, Loren Lipworth, Deepak K. Gupta, Debra D. Dixon, Wei Zheng, Ravi Shah and Danxia Yu
    Citation: BMC Medicine 2024 22:249
  41. Most women use medication during pregnancy. Pregnancy-induced changes in physiology may require antenatal dose alterations. Yet, evidence-based doses in pregnancy are missing. Given historically limited data, ...

    Authors: Charlotte Koldeweij, Mirèse Kleuskens, Carlijn Litjens, Bryony Dean Franklin, Hubertina C. J. Scheepers and Saskia N. de Wildt
    Citation: BMC Medicine 2024 22:248
  42. Analyzing distance-dependent functional connectivity density (FCD) yields valuable insights into patterns of brain activity. Nevertheless, whether alterations of FCD in non-acute stroke patients are associated...

    Authors: Wenjun Hong, Zaixing Liu, Xin Zhang, Ming Li, Zhixuan Yu, Yuxin Wang, Minmin Wang, Yanan Wu, Shengjie Fang, Bo Yang, Rong Xu and Zhiyong Zhao
    Citation: BMC Medicine 2024 22:247
  43. Intracerebral hemorrhage (ICH) is a common stroke type with high morbidity and mortality. There are mainly three surgical methods for treating ICH. Unfortunately, thus far, no specific surgical method has been...

    Authors: Xinghua Xu, Huaping Zhang, Jiashu Zhang, Ming Luo, Qun Wang, Yining Zhao, Zhichao Gan, Bainan Xu and Xiaolei Chen
    Citation: BMC Medicine 2024 22:244
  44. Understanding the enduring respiratory consequences of severe COVID-19 is crucial for comprehensive patient care. This study aims to evaluate the impact of post-COVID conditions on respiratory sequelae of seve...

    Authors: Enrique Alfaro, Elena Díaz-García, Sara García-Tovar, Raúl Galera, Raquel Casitas, María Torres-Vargas, Cristina López-Fernández, José M. Añón, Francisco García-Río and Carolina Cubillos-Zapata
    Citation: BMC Medicine 2024 22:242