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  1. Gonadotropin-releasing hormone (GnRH) antagonists are a promising therapeutic approach for treating hormone-dependent prostate cancer. Currently, the mainstream GnRH antagonists are polypeptide agents administ...

    Authors: Xin Li, Feifei Sun, Xiaolei Zhang, Pingping Lin, Kai Shen, Yu Shen, Lingyu Ma, Yu Cao and Chenjing Wang
    Citation: BMC Medicine 2023 21:129
    Content type: Research article Published on:

  2. Insomnia symptoms are widespread in the population and might have effects on many chronic conditions and their risk factors but previous research has focused on select hypothesised associations/effects rather ...

    Authors: Mark J. Gibson, Deborah A. Lawlor and Louise A. C. Millard
    Citation: BMC Medicine 2023 21:128
    Content type: Research article Published on:

  3. Postpartum psychiatric disorders (PPD) are common complications of childbirth. A common explanation for their development is that the psychological, hormonal, and immune changes associated with pregnancy and p...

    Authors: Min Luan, Fen Yang, Maohua Miao, Wei Yuan, Mika Gissler, Elizabeth V. Arkema, Donghao Lu, Jiong Li and Krisztina D. László
    Citation: BMC Medicine 2023 21:126
    Content type: Research article Published on:

  4. Respiratory syncytial virus (RSV) is among the leading childhood causes of viral pneumonia worldwide. Establishing RSV-associated morbidity and mortality is important in informing the development, delivery str...

    Authors: Bryan O. Nyawanda, Nickson Murunga, Nancy A. Otieno, Godfrey Bigogo, Joyce U. Nyiro, Elisabeth Vodicka, Marc Bulterys, D. James Nokes, Patrick K. Munywoki and Gideon O. Emukule
    Citation: BMC Medicine 2023 21:122
    Content type: Research article Published on:

  5. Approximately 97% of global deaths due to RSV occur in low- and middle-income countries (LMICs). Until recently, the only licensed preventive intervention has been a shortacting monoclonal antibody (mAb), pali...

    Authors: Rachel Wittenauer, Clint Pecenka and Ranju Baral
    Citation: BMC Medicine 2023 21:121
    Content type: Research article Published on:

  6. Respiratory syncytial virus (RSV) causes a substantial burden of acute lower respiratory infection in children under 5 years, particularly in low- and middle-income countries (LMICs). Maternal vaccine (MV) and...

    Authors: Mihaly Koltai, Jocelyn Moyes, Bryan Nyawanda, Joyce Nyiro, Patrick K. Munywoki, Stefano Tempia, Xiao Li, Marina Antillon, Joke Bilcke, Stefan Flasche, Philippe Beutels, D. James Nokes, Cheryl Cohen and Mark Jit
    Citation: BMC Medicine 2023 21:120
    Content type: Research article Published on:

  7. Severe malaria is a potentially fatal condition that requires urgent treatment. In a clinical trial, a sub-group of children treated with rectal artesunate (RAS) before being referred to a health facility had ...

    Authors: Manuel W. Hetzel, Jean Okitawutshu, Antoinette Tshefu, Elizabeth Omoluabi, Phyllis Awor, Aita Signorell, Marek Kwiatkowski, Mark J. Lambiris, Theodoor Visser, Justin M. Cohen, Valentina Buj, Christian Burri and Christian Lengeler
    Citation: BMC Medicine 2023 21:119
    Content type: Correspondence Published on:

    The original article was published in BMC Medicine 2022 20:343

    The Correspondence to this article has been published in BMC Medicine 2023 21:118

  8. CARAMAL was a large observational study which recorded mortality in children with suspected severe malaria before and after the roll-out of rectal artesunate in Nigeria, Uganda and the Democratic Republic of t...

    Authors: James A. Watson, Thomas J. Peto and Nicholas J. White
    Citation: BMC Medicine 2023 21:118
    Content type: Correspondence Published on:

    The original article was published in BMC Medicine 2022 20:343

    The Correspondence to this article has been published in BMC Medicine 2023 21:119

  9. Epicardial adipose tissue (EAT) has been suggested to exert deleterious effects on myocardium and cardiovascular disease (CVD) consequence. We evaluated the associations of EAT thickness with adverse outcomes ...

    Authors: Manting Choy, Yuwen Huang, Yang Peng, Weihao Liang, Xin He, Chen Chen, Jiayong Li, Wengen Zhu, Fang-fei Wei, Yugang Dong, Chen Liu and Yuzhong Wu
    Citation: BMC Medicine 2023 21:117
    Content type: Research article Published on:

  10. The American Heart Association recently updated its construct of what constitutes cardiovascular health (CVH), called Life’s Essential 8. We examined the association of total and individual CVH metrics according ...

    Authors: Jiahong Sun, Yanzhi Li, Min Zhao, Xiao Yu, Cheng Zhang, Costan G. Magnussen and Bo Xi
    Citation: BMC Medicine 2023 21:116
    Content type: Research article Published on:

  11. Adenoma-adenocarcinoma transition is a key feature of colorectal cancer (CRC) occurrence and is closely regulated by tumor-associated macrophages (TAMs) and CD8+ T cells. Here, we investigated the effect of the N...

    Authors: Shunyi Wang, Yihe Kuai, Simin Lin, Li Li, Quliang Gu, Xiaohan Zhang, Xiaoming Li, Yajun He, Sishuo Chen, Xiaoru Xia, Zhang Ruan, Caixia Lin, Yi Ding, Qianqian Zhang, Cuiling Qi, Jiangchao Li…
    Citation: BMC Medicine 2023 21:115
    Content type: Research article Published on:

  12. Emerging data suggests the neuroprotective and anti-neuroinflammatory effects of glucosamine. We aimed to examine the association between regular glucosamine use and risk of incident dementia, including dement...

    Authors: Jiazhen Zheng, Can Ni, Yingchai Zhang, Jinghan Huang, Daniel Nyarko Hukportie, Buwen Liang and Shaojun Tang
    Citation: BMC Medicine 2023 21:114
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Medicine 2023 21:175

  13. Authors: Shile Qi, Vince D. Calhoun, Daoqiang Zhang, Jeremy Miller, Zhi-De Deng, Katherine L. Narr, Yvette Sheline, Shawn M. McClintock, Rongtao Jiang, Xiao Yang, Joel Upston, Tom Jones, Jing Sui and Christopher C. Abbott
    Citation: BMC Medicine 2023 21:113
    Content type: Correction Published on:

    The original article was published in BMC Medicine 2022 20:477

  14. Studies included in a meta-analysis are often heterogeneous. The traditional random-effects models assume their true effects to follow a normal distribution, while it is unclear if this critical assumption is ...

    Authors: Ziyu Liu, Fahad M. Al Amer, Mengli Xiao, Chang Xu, Luis Furuya-Kanamori, Hwanhee Hong, Lianne Siegel and Lifeng Lin
    Citation: BMC Medicine 2023 21:112
    Content type: Research article Published on:

  15. The COVID-19 pandemic has highlighted health disparities affecting ethnic minority communities. There is growing concern about the lack of diversity in clinical trials. This study aimed to assess the represent...

    Authors: Mayur Murali, Leher Gumber, Hannah Jethwa, Divolka Ganesh, Jamie Hartmann-Boyce, Harpreet Sood, Francesco Zaccardi and Kamlesh Khunti
    Citation: BMC Medicine 2023 21:111
    Content type: Research article Published on:

    The Commentary to this article has been published in BMC Medicine 2023 21:308

  16. The global spread of COVID-19 created an explosion in rapid tests with results in < 1 hour, but their relative performance characteristics are not fully understood yet. Our aim was to determine the most sensit...

    Authors: Areti Angeliki Veroniki, Andrea C. Tricco, Jennifer Watt, Sofia Tsokani, Paul A. Khan, Charlene Soobiah, Ahmed Negm, Amanda Doherty-Kirby, Paul Taylor, Carole Lunny, Jessie McGowan, Julian Little, Patrick Mallon, David Moher, Sabrina Wong, Jacqueline Dinnes…
    Citation: BMC Medicine 2023 21:110
    Content type: Review Published on:

  17. With today’s pace of rapid technological advancement, many patient issues in modern medicine are increasingly solvable by mobile app solutions, which also have the potential to transform how clinical research ...

    Authors: Robert G. Mannino, Santiago J. Arconada Alvarez, Morgan Greenleaf, Maren Parsell, Comfort Mwalija and Wilbur A. Lam
    Citation: BMC Medicine 2023 21:109
    Content type: Opinion Published on:

  18. Previous studies have suggested that gestational weight gain (GWG) outside an optimal range increases the risks of neurodevelopmental disorders (NDDs) in offspring including autism spectrum disorder (ASD), int...

    Authors: Shuyun Chen, Mengyu Fan, Brian K. Lee, Christina Dalman, Håkan Karlsson and Renee M. Gardner
    Citation: BMC Medicine 2023 21:108
    Content type: Research article Published on:

  20. Influenza is a major year-round cause of respiratory illness in Kenya, particularly in children under 5. Current influenza vaccines result in short-term, strain-specific immunity and were found in a previous s...

    Authors: Naomi R. Waterlow, Sreejith Radhakrishnan, Jeanette Dawa, Edwin van Leeuwen, Simon R. Procter, Philipp Lambach, Joseph Bresee, Marie Mazur, Rosalind M. Eggo and Mark Jit
    Citation: BMC Medicine 2023 21:106
    Content type: Research article Published on:

    The Correspondence to this article has been published in BMC Medicine 2023 21:273

    The Correspondence to this article has been published in BMC Medicine 2023 21:301

  21. When tackling complex public health challenges such as childhood obesity, interventions focused on immediate causes, such as poor diet and physical inactivity, have had limited success, largely because upstrea...

    Authors: Wanchuang Zhu, Roman Marchant, Richard W. Morris, Louise A. Baur, Stephen J. Simpson and Sally Cripps
    Citation: BMC Medicine 2023 21:105
    Content type: Research article Published on:

  22. Female reproductive factors are gaining prominence as factors that enhance cardiovascular disease (CVD) risk; nonetheless, menstrual cycle characteristics are under-recognized as a factor associated with CVD. ...

    Authors: Kelvin Okoth, William Parry Smith, G. Neil Thomas, Krishnarajah Nirantharakumar and Nicola J. Adderley
    Citation: BMC Medicine 2023 21:104
    Content type: Research article Published on:

  23. Current evidence relating birthweight and gestational age to cardiovascular risk is conflicting. Whether these factors have independent or interactive impacts on cardiovascular parameters during early childhoo...

    Authors: Bowen Du, Hualin Wang, Yujian Wu, Zhuoyan Li, Yiwei Niu, Qianchuo Wang, Lin Zhang, Sun Chen, Yurong Wu, Jihong Huang, Kun Sun and Jian Wang
    Citation: BMC Medicine 2023 21:103
    Content type: Research article Published on:

  26. A global plan has been set to end human deaths from dog-mediated rabies by 2030 ("Zero-by-30"), but whether it could be achieved in some countries, such as China, remains unclear. Although elimination strategi...

    Authors: Qiulan Chen, Qiuping Liu, Chao Gong, Wenwu Yin, Di Mu, Yu Li, Shujun Ding, Yifang Liu, Hao Yang, Shuwu Zhou, Sa Chen, Zhongfa Tao, Yanping Zhang and Xun Tang
    Citation: BMC Medicine 2023 21:100
    Content type: Research article Published on:

  27. Metabolomic changes during pregnancy have been suggested to underlie the etiology of gestational diabetes mellitus (GDM). However, research on metabolites during preconception is lacking. Therefore, this study...

    Authors: Ling-Jun Li, Ximeng Wang, Yap Seng Chong, Jerry Kok Yen Chan, Kok Hian Tan, Johan G. Eriksson, Zhongwei Huang, Mohammad L. Rahman, Liang Cui and Cuilin Zhang
    Citation: BMC Medicine 2023 21:99
    Content type: Research article Published on:

  28. Hepatitis B virus (HBV) core protein-targeting antivirals (CpTAs) are promising therapeutic agents for treating chronic hepatitis B (CHB). In this study, the antiviral activity, pharmacokinetics (PK), and tole...

    Authors: Haiyan Jia, Jiajia Mai, Min Wu, Hong Chen, Xiaojiao Li, Cuiyun Li, Jingrui Liu, Chengjiao Liu, Yue Hu, Xiaoxue Zhu, Xiuhong Jiang, Bo Hua, Tian Xia, Gang Liu, Aiyun Deng, Bo Liang…
    Citation: BMC Medicine 2023 21:98
    Content type: Research article Published on:

  29. Understanding the overall effectiveness of non-pharmaceutical interventions to control the COVID-19 pandemic and reduce the burden of disease is crucial for future pandemic planning. However, quantifying the e...

    Authors: Rachael Pung, Hannah E. Clapham, Timothy W. Russell, Vernon J. Lee and Adam J. Kucharski
    Citation: BMC Medicine 2023 21:97
    Content type: Research article Published on:

  30. Extracellular vesicles (EVs) derived from bone marrow mesenchymal stem cells (MSCs) pretreated with atorvastatin (ATV) (MSCATV-EV) have a superior cardiac repair effect on acute myocardial infarction (AMI). The m...

    Authors: Yu Ning, Peisen Huang, Guihao Chen, Yuyan Xiong, Zhaoting Gong, Chunxiao Wu, Junyan Xu, Wenyang Jiang, Xiaosong Li, Ruijie Tang, Lili Zhang, Mengjin Hu, Jing Xu, Jun Xu, Haiyan Qian, Chen Jin…
    Citation: BMC Medicine 2023 21:96
    Content type: Research article Published on:

  31. While epidemiological studies have found correlations between light at night (LAN) and health effects, none has so far investigated the impacts of LAN on population mortality yet. We aimed to estimate the rela...

    Authors: Yao Lu, Peng Yin, Jie Wang, Yiping Yang, Fei Li, Hong Yuan, Shenxin Li, Zheng Long and Maigeng Zhou
    Citation: BMC Medicine 2023 21:95
    Content type: Research article Published on:

  32. Previous studies have shown that monotherapy with apatinib, an oral tyrosine kinase inhibitor, has promising efficacy for treating recurrent or metastatic (RM) nasopharyngeal carcinoma (NPC) patients. In this ...

    Authors: Lin-Quan Tang, Xiao-Yun Li, Zhi-Ming Li, Zhi-Gang Liu, Miao-Zhen Lin, Huan Zhou, Qi-Wen Yu, Jian Zhou, Chong Zhao, Ze-Bin Chen, Xi-Cheng Wang, Jia-Yu Peng, Qiu-Yan Chen, Wen-Feng Fang, Yun-Peng Yang, Bei Zhang…
    Citation: BMC Medicine 2023 21:94
    Content type: Research article Published on:

  33. Mitochondrial transplantation (MTx) is an emerging but poorly understood technology with the potential to mitigate severe ischemia–reperfusion injuries after cardiac arrest (CA). To address critical gaps in th...

    Authors: Kei Hayashida, Ryosuke Takegawa, Yusuke Endo, Tai Yin, Rishabh C. Choudhary, Tomoaki Aoki, Mitsuaki Nishikimi, Atsushi Murao, Eriko Nakamura, Muhammad Shoaib, Cyrus Kuschner, Santiago J. Miyara, Junhwan Kim, Koichiro Shinozaki, Ping Wang and Lance B. Becker
    Citation: BMC Medicine 2023 21:56
    Content type: Research article Published on:

  35. The identification of effective dementia prevention strategies is a major public health priority, due to the enormous and growing societal cost of this condition. Consumption of a Mediterranean diet (MedDiet) ...

    Authors: Oliver M. Shannon, Janice M. Ranson, Sarah Gregory, Helen Macpherson, Catherine Milte, Marleen Lentjes, Angela Mulligan, Claire McEvoy, Alex Griffiths, Jamie Matu, Tom R. Hill, Ashley Adamson, Mario Siervo, Anne Marie Minihane, Graciela Muniz-Tererra, Craig Ritchie…
    Citation: BMC Medicine 2023 21:81
    Content type: Research article Published on:

  36. Childhood maltreatment is associated with depression and cardiometabolic disease in adulthood. However, the relationships with these two diseases have so far only been evaluated in different samples and with d...

    Authors: Camille Souama, Femke Lamers, Yuri Milaneschi, Christiaan H. Vinkers, Serena Defina, Linda Garvert, Frederike Stein, Tom Woofenden, Katharina Brosch, Udo Dannlowski, Henrike Galenkamp, Ron de Graaf, Vincent W. V. Jaddoe, Anja Lok, Bas B. van Rijn, Henry Völzke…
    Citation: BMC Medicine 2023 21:93
    Content type: Research article Published on:

  37. Preterm premature rupture of membranes (PPROM), which is associated with vaginal dysbiosis, is responsible for up to one-third of all preterm births. Consecutive ascending colonization, infection, and inflamma...

    Authors: Luiz Gustavo dos Anjos Borges, Jana Pastuschek, Yvonne Heimann, Kristin Dawczynski, Ekkehard Schleußner, Dietmar H. Pieper and Janine Zöllkau
    Citation: BMC Medicine 2023 21:92
    Content type: Research article Published on:

  38. Social prescribing (SP) usually involves linking patients in primary care with services provided by the voluntary and community sector. Preliminary evidence suggests that SP may offer a means of connecting pat...

    Authors: Sara Calderón-Larrañaga, Trish Greenhalgh, Megan Clinch, John Robson, Isabel Dostal, Fabiola Eto and Sarah Finer
    Citation: BMC Medicine 2023 21:91
    Content type: Research article Published on:

  39. Pre-eclampsia (PE) is one of the leading causes of maternal and fetal morbidity/mortality during pregnancy, and alpha-2-macroglobulin (A2M) is associated with inflammatory signaling; however, the pathophysiolo...

    Authors: Jingyun Wang, Ping Zhang, Mengyuan Liu, Zhengrui Huang, Xiaofeng Yang, Yuzhen Ding, Jia Liu, Xin Cheng, Shujie Xu, Meiyao He, Fengxiang Zhang, Guang Wang, Ruiman Li and Xuesong Yang
    Citation: BMC Medicine 2023 21:90
    Content type: Research article Published on:

  40. Understanding the effects of risk factor burden and genetic predisposition on the long-term risk of atrial fibrillation (AF) is important to improve public health initiatives. However, the 10-year risk of AF c...

    Authors: Junguo Zhang, Ge Chen, ChongJian Wang, Xiaojie Wang, Zhengmin (Min) Qian, Miao Cai, Michael G. Vaughn, Elizabeth Bingheim, Haitao Li, Yanhui Gao, Gregory Y. H. Lip and Hualiang Lin
    Citation: BMC Medicine 2023 21:88
    Content type: Research article Published on:

  41. Overall survival (OS) is the gold standard endpoint to assess treatment efficacy in cancer clinical trials. In metastatic breast cancer (mBC), progression-free survival (PFS) is commonly used as an intermediat...

    Authors: Coralie Courtinard, Sophie Gourgou, William Jacot, Matthieu Carton, Olivier Guérin, Laure Vacher, Aurélie Bertaut, Marie-Cécile Le Deley, David Pérol, Patricia Marino, Christelle Levy, Lionel Uwer, Geneviève Perrocheau, Renaud Schiappa, Florence Bachelot, Damien Parent…
    Citation: BMC Medicine 2023 21:87
    Content type: Research article Published on:

  42. A Phase II study was undertaken to evaluate the safety and efficacy of the neoadjuvant socazolimab, a novel PD-L1 inhibitor, in combination with nab-paclitaxel and cisplatin for locally advanced esophageal squ...

    Authors: Yong Li, Aiping Zhou, Shuoyan Liu, Ming He, Keneng Chen, Ziqiang Tian, Yin Li, Jianjun Qin, Zhen Wang, Haiquan Chen, Hui Tian, Yue Yu, Wang Qu, Liyan Xue, Shun He, Shuhang Wang…
    Citation: BMC Medicine 2023 21:86
    Content type: Research article Published on:

  43. The COVID-19 vaccine supply shortage in 2021 constrained roll-out efforts in Africa while populations experienced waves of epidemics. As supply improves, a key question is whether vaccination remains an impact...

    Authors: Yang Liu, Simon R. Procter, Carl A. B. Pearson, Andrés Madriz Montero, Sergio Torres-Rueda, Elias Asfaw, Benjamin Uzochukwu, Tom Drake, Eleanor Bergren, Rosalind M. Eggo, Francis Ruiz, Nicaise Ndembi, Justice Nonvignon, Mark Jit and Anna Vassall
    Citation: BMC Medicine 2023 21:85
    Content type: Research article Published on:

  44. Micronutrients play an essential role at every stage of the immune response, and deficiencies can therefore lead to increased susceptibility to infections. Previous observational studies and randomized control...

    Authors: Helene M. Flatby, Anuradha Ravi, Jan K. Damås, Erik Solligård and Tormod Rogne
    Citation: BMC Medicine 2023 21:84
    Content type: Research article Published on:

  45. Several studies on long-term air pollution exposure and sleep have reported inconsistent results. Large-scale studies on short-term air pollution exposures and sleep have not been conducted. We investigated th...

    Authors: Peining Zhou, Jing Ma, Xueying Li, Yixue Zhao, Kunyao Yu, Rui Su, Rui Zhou, Hui Wang and Guangfa Wang
    Citation: BMC Medicine 2023 21:83
    Content type: Research article Published on:

  46. Water intake and hydration status have been suggested to impact cognition; however, longitudinal evidence is limited and often inconsistent. This study aimed to longitudinally assess the association between hy...

    Authors: Stephanie K. Nishi, Nancy Babio, Indira Paz-Graniel, Lluís Serra-Majem, Jesús Vioque, Montserrat Fitó, Dolores Corella, Xavier Pintó, Aurora Bueno-Cavanillas, Josep A. Tur, Laura Diez-Ricote, J. Alfredo Martinez, Carlos Gómez-Martínez, Andrés González-Botella, Olga Castañer, Andrea Alvarez-Sala…
    Citation: BMC Medicine 2023 21:82
    Content type: Research article Published on:

  47. The complexity of sleep hinders the formulation of sleep guidelines. Recent studies suggest that different unhealthy sleep characteristics jointly increase the risks for cardiovascular disease (CVD). This stud...

    Authors: Bo-Huei Huang, Borja del Pozo Cruz, Armando Teixeira-Pinto, Peter A. Cistulli and Emmanuel Stamatakis
    Citation: BMC Medicine 2023 21:75
    Content type: Research article Published on:

  48. Amino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk of colorectal cancer. We investiga...

    Authors: Joseph A. Rothwell, Jelena Bešević, Niki Dimou, Marie Breeur, Neil Murphy, Mazda Jenab, Roland Wedekind, Vivian Viallon, Pietro Ferrari, David Achaintre, Audrey Gicquiau, Sabina Rinaldi, Augustin Scalbert, Inge Huybrechts, Cornelia Prehn, Jerzy Adamski…
    Citation: BMC Medicine 2023 21:80
    Content type: Research article Published on:

  49. Anti-Müllerian hormone (AMH) is released by testicular Sertoli cells and of great importance during fetal male sexual development, but less is known about the role of circulating AMH during adulthood. In vitro...

    Authors: Rune Holt, Sam Kafai Yahyavi, Ireen Kooij, Christine Hjorth Andreassen, Anna-Maria Andersson, Anders Juul, Niels Jørgensen and Martin Blomberg Jensen
    Citation: BMC Medicine 2023 21:79
    Content type: Research article Published on:

  50. Both BNT162b2 (Pfizer–BioNTech) and ChAdOx1 nCoV-19 (Oxford–AstraZeneca) vaccines have shown high efficacy against COVID-19 in randomized controlled trials. However, their comparative effectiveness against COV...

    Authors: Jie Wei, Weiya Zhang, Michael Doherty, Zachary S. Wallace, Jeffrey A. Sparks, Na Lu, Xiaoxiao Li, Chao Zeng, Guanghua Lei and Yuqing Zhang
    Citation: BMC Medicine 2023 21:78
    Content type: Research article Published on:
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