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  1. Environmental factors play an important role in developing mental disorders. This study aimed to investigate the associations of metal and nonmetal elements in drinking water with the risk of depression and an...

    Authors: Shuduo Zhou, Mintao Su, Peng Shen, Zongming Yang, Pengfei Chai, Shengzhi Sun, Hongbo Lin, Liming Shui, Na Zhang, Ming Xu, Zhi-Jie Zheng, Jianbing Wang, Zhenyu Zhang and Kun Chen
    Citation: BMC Medicine 2024 22:53
  2. Context-specific interventions may contribute to sustained behaviour change and improved health outcomes. We evaluated the real-world effects of supermarket nudging and pricing strategies and mobile physical a...

    Authors: Josine M. Stuber, Joreintje D. Mackenbach, Gert-Jan de Bruijn, Marleen Gillebaart, Jody C. Hoenink, Cédric N. H. Middel, Denise T. D. de Ridder, Yvonne T. van der Schouw, Edith G. Smit, Elizabeth Velema, Anne L. Vos, Wilma E. Waterlander, Jeroen Lakerveld and Joline W. J. Beulens
    Citation: BMC Medicine 2024 22:52

    The Commentary to this article has been published in BMC Medicine 2024 22:87

  3. There are over 53million children worldwide under five with developmental disabilities who require effective interventions to support their health and well-being. However, challenges in delivering intervention...

    Authors: Tracey Smythe, Nathaniel Scherer, Carol Nanyunja, Cally J. Tann and Bolajoko O. Olusanya
    Citation: BMC Medicine 2024 22:51
  4. This study aims to investigate potential interactions between maternal smoking around birth (MSAB) and type 2 diabetes (T2D) pathway-specific genetic risks in relation to the development of T2D in offspring. A...

    Authors: Wenbo Jiang, Yiwei Tang, Ruiming Yang, Yujia Long, Changhao Sun, Tianshu Han and Wei Wei
    Citation: BMC Medicine 2024 22:50
  5. There is currently a deficit of knowledge about how to define, quantify, and measure different aspects of daily routine disruptions amid large-scale disasters like COVID-19, and which psychiatric symptoms were...

    Authors: Huinan Liu, Tiffany Junchen Tao, Selina Kit Yi Chan, Jeremy Chi Him Ma, Abby Yan Tung Lau, Ernest Tsun Fung Yeung, Stevan E. Hobfoll and Wai Kai Hou
    Citation: BMC Medicine 2024 22:49
  6. Patients recovering from SARS-CoV-2 infection and acute COVID-19 illness can experience a range of long-term post-acute effects. The potential clinical and economic burden of these outcomes in the USA is uncle...

    Authors: Amie Scott, Wajeeha Ansari, Richard Chambers, Maya Reimbaeva, Tomasz Mikolajczyk, Michael Benigno, Florin Draica and Joanna Atkinson
    Citation: BMC Medicine 2024 22:47
  7. Long-term health outcomes in children and young people (CYP) after COVID-19 infection are not well understood and studies with control groups exposed to other infections are lacking. This study aimed to invest...

    Authors: Ekaterina Pazukhina, Mikhail Rumyantsev, Dina Baimukhambetova, Elena Bondarenko, Nadezhda Markina, Yasmin El-Taravi, Polina Petrova, Anastasia Ezhova, Margarita Andreeva, Ekaterina Iakovleva, Polina Bobkova, Maria Pikuza, Anastasia Trefilova, Elina Abdeeva, Aysylu Galiautdinova, Yulia Filippova…
    Citation: BMC Medicine 2024 22:48
  8. Post-COVID conditions encompass a range of long-term symptoms after SARS-CoV-2 infection. The potential clinical and economic burden in the United States is unclear. We evaluated diagnoses, medications, health...

    Authors: Amie Scott, Wajeeha Ansari, Farid Khan, Richard Chambers, Michael Benigno, Manuela Di Fusco, Leah McGrath, Deepa Malhotra, Florin Draica, Jennifer Nguyen, Joanna Atkinson and Jessica E. Atwell
    Citation: BMC Medicine 2024 22:46
  9. Immune checkpoint inhibitors (ICIs) have contributed to a significant advancement in the treatment of cancer, leading to improved clinical outcomes in many individuals with advanced disease. Both preclinical a...

    Authors: Bingxin Gong, Yusheng Guo, Yi Li, Jing Wang, Guofeng Zhou, Yong-hao Chen, Tong Nie, Ming Yang, Kun Luo, Chuansheng Zheng, Feng Pan, Bo Liang and Lian Yang
    Citation: BMC Medicine 2024 22:44
  10. Contemporary debates about drug pricing feature several widely held misconceptions, including the relationship between incentives and innovation, the proportion of total healthcare spending on pharmaceuticals,...

    Authors: Sreeram V. Ramagopalan, Jose Diaz, Grace Mitchell, Louis P. Garrison Jr. and Peter Kolchinsky
    Citation: BMC Medicine 2024 22:45
  11. Mammography screening programmes (MSP) aim to reduce breast cancer mortality by shifting diagnoses to earlier stages. However, it is difficult to evaluate the effectiveness of current MSP because analyses can ...

    Authors: Laura Buschmann, Ina Wellmann, Nadine Bonberg, Jürgen Wellmann, Hans-Werner Hense, André Karch and Heike Minnerup
    Citation: BMC Medicine 2024 22:43
  12. Nutritional intervention preconception and throughout pregnancy has been proposed as an approach to promoting healthy postnatal weight gain in the offspring but few randomised trials have examined this.

    Authors: Jaz Lyons-Reid, José G. B. Derraik, Timothy Kenealy, Benjamin B. Albert, J. Manuel Ramos Nieves, Cathriona R. Monnard, Phil Titcombe, Heidi Nield, Sheila J. Barton, Sarah El-Heis, Elizabeth Tham, Keith M. Godfrey, Shiao-Yng Chan and Wayne S. Cutfield
    Citation: BMC Medicine 2024 22:39
  13. Microsatellite instability-high (MSI-H) is a unique genomic status in many cancers. However, its role in the genomic features and immunotherapy in cholangiocarcinoma (CCA) is unclear. This study aimed to syste...

    Authors: Xu Yang, Baofeng Lian, Nan Zhang, Junyu Long, Yiran Li, Jingnan Xue, Xiangqi Chen, Yunchao Wang, Yanyu Wang, Ziyu Xun, Mingjian Piao, Chenpei Zhu, Shanshan Wang, Huishan Sun, Zhijian Song, Leilei Lu…
    Citation: BMC Medicine 2024 22:42
  14. Conventional vector control strategies have significantly reduced the malaria burden. The sustainability of these methods is currently challenged. Odour-based traps are emerging technologies that can complemen...

    Authors: Yared Debebe, Habte Tekie, Sisay Dugassa, Richard J. Hopkins, Sharon Rose Hill and Rickard Ignell
    Citation: BMC Medicine 2024 22:41
  15. To date, almost no research on the psychosocial implications of albinism has been conducted in France and an exploration of albinism-related experiences could be beneficial, in order to better understand this ...

    Authors: Hugo Fournier, Marie Hasdenteufel, Constance Garrouteigt, Mathieu Perie, Antoine Gliksohn, Béatrice Jouanne, Smail Hadj-Rabia, Benoit Arveiler, Fanny Morice-Picard and Bruno Quintard
    Citation: BMC Medicine 2024 22:40
  16. Higher maternal pre-pregnancy body mass index (BMI) is associated with adverse pregnancy and perinatal outcomes. However, whether these associations are causal remains unclear.

    Authors: Maria Carolina Borges, Gemma L. Clayton, Rachel M. Freathy, Janine F. Felix, Alba Fernández-Sanlés, Ana Gonçalves Soares, Fanny Kilpi, Qian Yang, Rosemary R. C. McEachan, Rebecca C. Richmond, Xueping Liu, Line Skotte, Amaia Irizar, Andrew T. Hattersley, Barbara Bodinier, Denise M. Scholtens…
    Citation: BMC Medicine 2024 22:32
  17. Incorrect drug ‘allergy’ labels remain a global public health concern. Identifying regional trends of drug allergy labeling can guide appropriate public health interventions, but longitudinal or population dru...

    Authors: Valerie Chiang, Andy Ka Chun Kan, Chinmoy Saha, Elaine Y. L. Au and Philip H. Li
    Citation: BMC Medicine 2024 22:30
  18. This study investigates the association between socioeconomic status (SES) and glycemic control in individuals with type 1 diabetes (T1D) using flash glucose monitoring (FGM) devices within a public health sys...

    Authors: Fernando Sebastian-Valles, Julia Martínez-Alfonso, Jose Alfonso Arranz Martin, Jessica Jiménez-Díaz, Iñigo Hernando Alday, Victor Navas-Moreno, Teresa Armenta Joya, Maria del Mar Fandiño García, Gisela Liz Román Gómez, Jon Garai Hierro, Luis Eduardo Lander Lobariñas, Purificación Martínez de Icaya, Miguel Antonio Sampedro-Nuñez, Vicente Martínez-Vizcaíno and Mónica Marazuela
    Citation: BMC Medicine 2024 22:37
  19. Continuous assessment and remote monitoring of cognitive function in individuals with mild cognitive impairment (MCI) enables tracking therapeutic effects and modifying treatment to achieve better clinical out...

    Authors: Yuri G. Rykov, Michael D. Patterson, Bikram A. Gangwar, Syaheed B. Jabar, Jacklyn Leonardo, Kok Pin Ng and Nagaendran Kandiah
    Citation: BMC Medicine 2024 22:36
  20. Adverse pregnancy outcomes (APO) may unmask or exacerbate a woman’s underlying risk for coronary heart disease (CHD). We estimated associations of maternal and paternal genetically predicted liability for CHD ...

    Authors: Álvaro Hernáez, Karoline H. Skåra, Christian M. Page, Vera R. Mitter, Marta H. Hernández, Per Magnus, Pål R. Njølstad, Ole A. Andreassen, Elizabeth C. Corfield, Alexandra Havdahl, Øyvind Næss, Ben Brumpton, Bjørn Olav Åsvold, Deborah A. Lawlor, Abigail Fraser and Maria Christine Magnus
    Citation: BMC Medicine 2024 22:35
  21. Heart failure (HF) is a complex clinical syndrome with persistently high mortality. High-throughput proteomic technologies offer new opportunities to improve HF risk stratification, but their contribution rema...

    Authors: Kayode O. Kuku, Rebecca Oyetoro, Maryam Hashemian, Alicia A. Livinski, Joseph J. Shearer, Jungnam Joo, Bruce M. Psaty, Daniel Levy, Peter Ganz and Véronique L. Roger
    Citation: BMC Medicine 2024 22:34
  22. The endocannabinoid (eCB) system and the serotonin (5-HT) are both implicated in the severity of the depression. 5-HT is synthesized from the amino acid tryptophan (Trp), which is also a precursor for kynureni...

    Authors: Stefano Comai, Nicolas Nunez, Tobias Atkin, Maykel F. Ghabrash, Rita Zakarian, Allan Fielding, Marie Saint-Laurent, Nancy Low, Garrett Sauber, Eugenio Ragazzi, Cecilia J. Hillard and Gabriella Gobbi
    Citation: BMC Medicine 2024 22:33
  23. A previously trained deep learning-based smartphone app provides an artificial intelligence solution to help diagnose biliary atresia from sonographic gallbladder images, but it might be impractical to launch ...

    Authors: Wenying Zhou, Zejun Ye, Guangliang Huang, Xiaoer Zhang, Ming Xu, Baoxian Liu, Bowen Zhuang, Zijian Tang, Shan Wang, Dan Chen, Yunxiang Pan, Xiaoyan Xie, Ruixuan Wang and Luyao Zhou
    Citation: BMC Medicine 2024 22:29
  24. Current hypertension guidelines recommend combination of an angiotensin-converting enzyme inhibitor or angiotensin-receptor blocker with a calcium-channel blocker or thiazide diuretic as initial antihypertensi...

    Authors: Qi-Fang Huang, Di Zhang, Yihong Luo, Kun Hu, Qiong Wu, Hailong Qiu, Fei Xu, Mei-Ling Wang, Xin Chen, Yan Li and Ji-Guang Wang
    Citation: BMC Medicine 2024 22:28
  25. Due to low numbers of active infections and persons presenting to health facilities for malaria treatment, case-based surveillance is inefficient for understanding the remaining disease burden in low malaria t...

    Authors: Alicia Jaramillo-Underwood, Camelia Herman, Samuel E. Jean, Doug Nace, E. Scott Elder, Keri Robinson, Alaine Knipes, Caitlin M. Worrell, LeAnne M. Fox, Luccene Desir, Carl Fayette, Alain Javel, Franck Monestime, Kimberly E. Mace, Venkatachalam Udhayakumar, Kimberly Y. Won…
    Citation: BMC Medicine 2024 22:31
  26. This study estimated the prevalence of evidence-based care received by a population-based sample of Australian residents in long-term care (LTC) aged ≥ 65 years in 2021, measured by adherence to clinical pract...

    Authors: Peter D. Hibbert, Charlotte J. Molloy, Ian D. Cameron, Leonard C. Gray, Richard L. Reed, Louise K. Wiles, Johanna Westbrook, Gaston Arnolda, Rebecca Bilton, Ruby Ash, Andrew Georgiou, Alison Kitson, Clifford F. Hughes, Susan J. Gordon, Rebecca J. Mitchell, Frances Rapport…
    Citation: BMC Medicine 2024 22:22
  27. The NHS Health Check is a preventive programme in the UK designed to screen for cardiovascular risk and to aid in primary disease prevention. Despite its widespread implementation, the effectiveness of the NHS...

    Authors: Celeste McCracken, Zahra Raisi-Estabragh, Liliana Szabo, John Robson, Betty Raman, Anya Topiwala, Adriana Roca-Fernández, Masud Husain, Steffen E. Petersen, Stefan Neubauer and Thomas E. Nichols
    Citation: BMC Medicine 2024 22:1
  28. We recently reported the first clinical case of bladder fermentation syndrome (BFS) or urinary auto-brewery syndrome, which caused the patient to fail abstinence monitoring. In BFS, ethanol is generated by Cra...

    Authors: Kenichi Tamama, Katherine M. Kruckenberg and Andrea F. DiMartini
    Citation: BMC Medicine 2024 22:26
  29. Multiple long-term conditions—the co-existence of two or more chronic health conditions in an individual—present an increasing challenge to populations and healthcare systems worldwide. This challenge is keenl...

    Authors: Sue Bellass, Thomas Scharf, Linda Errington, Kelly Bowden Davies, Sian Robinson, Adam Runacres, Jodi Ventre, Miles D. Witham, Avan A. Sayer and Rachel Cooper
    Citation: BMC Medicine 2024 22:25
  30. Pyroptosis, mediated by gasdermins with the release of multiple inflammatory cytokines, has emerged as playing an important role in targeted therapy and immunotherapy due to its effectiveness at inhibiting tum...

    Authors: Wenqiong Chen, Yi He, Guowei Zhou, Xiang Chen, Youqiong Ye, Guanxiong Zhang and Hong Liu
    Citation: BMC Medicine 2024 22:24
  31. Little is known regarding the association of interviewer-reported cognitive problems (ICP) with age-related cognitive decline. We aimed to investigate the independent associations of ICP and the combined assoc...

    Authors: Yuhui Huang, Hui Chen, Mengyan Gao, Xiaozhen Lv, Ting Pang, Shuang Rong, Xin Xu and Changzheng Yuan
    Citation: BMC Medicine 2024 22:23
  32. Little is known about the effects of night shifts and their interactions with genetic factors on chronic obstructive pulmonary disease (COPD). In this study, we aim to investigate relationships between long-te...

    Authors: Jia Li, Liangle Yang, Yuxin Yao, Pei Gu, Yujia Xie, Haoyu Yin, Mingyue Xue, Yu Jiang, Jianghong Dai and Jixuan Ma
    Citation: BMC Medicine 2024 22:16
  33. There is increasing evidence for the role of environmental factors and exposure to the natural environment on a wide range of health outcomes. Whether exposure to green space, blue space, and the natural envir...

    Authors: Bao-Peng Liu, Rachel R. Huxley, Tamara Schikowski, Ke-Jia Hu, Qi Zhao and Cun-Xian Jia
    Citation: BMC Medicine 2024 22:15
  34. Hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR + /HER2 −) advanced breast cancer is a prevalent subtype among postmenopausal women. Despite the growing number of randomized cli...

    Authors: Hanqiao Shao, Mingye Zhao, Ai-Jia Guan, Taihang Shao, Dachuang Zhou, Guo Yu and Wenxi Tang
    Citation: BMC Medicine 2024 22:13
  35. The health care is likely to break down unless we are able to increase the level of functioning for the growing number of patients with complex, chronic illnesses. Hence, novel high-capacity and cost-effective...

    Authors: Gerd Kvale, Eirik Søfteland, Marte Jürgensen, Ane Wilhelmsen-Langeland, Anne Haugstvedt, Sigurd William Hystad, Øystein Theodor Ødegaard-Olsen, Bernt Bøgvald Aarli, Sidsel Rykken and Bente Frisk
    Citation: BMC Medicine 2024 22:12
  36. The associations between trajectories of different health conditions and cognitive impairment among older adults were unknown. Our cohort study aimed to investigate the impact of various trajectories, includin...

    Authors: Min Du, Liyuan Tao, Min Liu and Jue Liu
    Citation: BMC Medicine 2024 22:20
  37. In the post-pandemic era, a wide range of COVID-19 sequelae is of growing health concern. However, the risks of digestive diseases in long COVID have not been comprehensively understood. To investigate the lon...

    Authors: Yuying Ma, Lijun Zhang, Rui Wei, Weiyu Dai, Ruijie Zeng, Dongling Luo, Rui Jiang, Zewei Zhuo, Qi Yang, Jingwei Li, Felix W Leung, Chongyang Duan, Weihong Sha and Hao Chen
    Citation: BMC Medicine 2024 22:14
  38. The benefits of first-line, cisplatin-based chemotherapy for muscle-invasive bladder cancer are limited due to intrinsic or acquired resistance to cisplatin. Increasing evidence has revealed the implication of...

    Authors: Hongjin Shi, Zhiyong Tan, Bowen Duan, Chunming Guo, Chong Li, Ting Luan, Ning Li, Yinglong Huang, Shi Chen, Jixian Gao, Wei Feng, Haole Xu, Jiansong Wang, Shi Fu and Haifeng Wang
    Citation: BMC Medicine 2024 22:19
  39. Due to the abundant usage of chemotherapy in young triple-negative breast cancer (TNBC) patients, the unbiased prognostic value of BRCA1-related biomarkers in this population remains unclear. In addition, whether...

    Authors: Yuwei Wang, Gwen M. H. E. Dackus, Efraim H. Rosenberg, Sten Cornelissen, Leonora W. de Boo, Annegien Broeks, Wim Brugman, Terry W. S. Chan, Paul J. van Diest, Michael Hauptmann, Natalie D. ter Hoeve, Olga I. Isaeva, Vincent M. T. de Jong, Katarzyna Jóźwiak, Roelof J. C. Kluin, Marleen Kok…
    Citation: BMC Medicine 2024 22:9
  40. Health care routinely fails Indigenous peoples and anti-Indigenous racism is common in clinical encounters. Clinical training programs aimed to enhance Indigenous cultural safety (ICS) rely on learner reported...

    Authors: Janet Smylie, Michael A. Rotondi, Sam Filipenko, William T. L. Cox, Diane Smylie, Cheryl Ward, Kristina Klopfer, Aisha K. Lofters, Braden O’Neill, Melissa Graham, Linda Weber, Ali N. Damji, Patricia G. Devine, Jane Collins and Billie-Jo Hardy
    Citation: BMC Medicine 2024 22:3
  41. Aggregate trends can be useful for summarizing large amounts of information, but this can obscure important distributional aspects. Some population subgroups can be worse off even as averages climb, for exampl...

    Authors: Yeeun Lee, Sarah Bolongaita, Ryoko Sato, Jesse B. Bump and Stéphane Verguet
    Citation: BMC Medicine 2024 22:21
  42. Methadone maintenance treatment (MMT) has been implemented in China for nearly two decades, with a significant decrease in the number of participants in recent years. However, there is a lack of comprehensive ...

    Authors: Xijia Tang, Wenxue Xiong, Wen Chen, Chijie Wang, Hexuan Wang, Boyu Li, Zirong Zhang and Li Ling
    Citation: BMC Medicine 2024 22:18
  43. Slower paces of aging are related to lower risk of developing diseases and premature death. Therefore, the greatest challenge of modern societies is to ensure that the increase in lifespan is accompanied by an...

    Authors: Joaquim Sol, Marta Ortega-Bravo, Manuel Portero-Otín, Gerard Piñol-Ripoll, Vicent Ribas-Ripoll, Eva Artigues-Barberà, Miquel Butí, Reinald Pamplona and Mariona Jové
    Citation: BMC Medicine 2024 22:17
  44. Dilation may be the first right ventricular change and accelerates the progression of threatening ventricular tachyarrhythmias and heart failure for patients with arrhythmogenic right ventricular cardiomyopath...

    Authors: Mengxia Fu, Xiumeng Hua, Songren Shu, Xinjie Xu, Hang Zhang, Zhiming Peng, Han Mo, Yanyun Liu, Xiao Chen, Yicheng Yang, Ningning Zhang, Xiaohu Wang, Zirui Liu, Guangxin Yue, Shengshou Hu and Jiangping Song
    Citation: BMC Medicine 2024 22:11
  45. Preterm birth (PTB) is a leading cause of child morbidity and mortality. Evidence suggests an increased risk with both maternal underweight and obesity, with some studies suggesting underweight might be a grea...

    Authors: R. P. Cornish, M. C. Magnus, S. K. Urhoj, G. Santorelli, L. G. Smithers, D. Odd, A. Fraser, S. E. Håberg, A. M. Nybo Andersen, K. Birnie, J. W. Lynch, K. Tilling and D. A. Lawlor
    Citation: BMC Medicine 2024 22:10
  46. Patients with type 2 diabetes (T2D) tend to have nonalcoholic fatty liver disease (NAFLD) with poorer prognosis. We performed this research to compare the risks of cardiovascular diseases, cirrhosis, liver-rel...

    Authors: Fu-Shun Yen, Ming-Chih Hou, James Cheng-Chung Wei, Ying-Hsiu Shih, Chii-Min Hwu and Chih-Cheng Hsu
    Citation: BMC Medicine 2024 22:8
  47. The devastating impact of youth mental health concerns is increasingly evident on a global scale. This crisis calls for innovative solutions that are sufficiently accessible, scalable, and cost-effective to su...

    Authors: Tasha L. Golden, Richard W. Ordway, Susan Magsamen, Aanchal Mohanty, Yifan Chen and T. W. Cherry Ng
    Citation: BMC Medicine 2024 22:7
  48. Long-term opioid use is associated with dependency, addiction, and serious adverse events. Although a framework to reduce inappropriate opioid prescribing exists, there is no consensus on prescribing indicator...

    Authors: Neetu Bansal, Stephen M. Campbell, Chiu-Yi Lin, Darren M. Ashcroft and Li-Chia Chen
    Citation: BMC Medicine 2024 22:5