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  1. Sodium bicarbonate (SB) infusion is commonly used to correct metabolic acidosis, but its clinical efficacy remains controversial. This study aims to investigate whether acid–base balance parameters should be a...

    Authors: Huaqing Liu, Yanmei Cao, Xiaoyan Xue, Zhenjiang Bai and Shuiyan Wu
    Citation: BMC Medicine 2023 21:473
  2. Emerging metabolomics-based studies suggested links between amino acid metabolism and metabolic dysfunction-associated fatty liver disease (MAFLD) risk; however, whether there exists an aetiological role of am...

    Authors: Jian Zhao, Jing Zeng, Cairong Zhu, Xuechao Li, Dong Liu, Jun Zhang, Fei Li, Giovanni Targher and Jian-Gao Fan
    Citation: BMC Medicine 2023 21:469
  3. Prior reviews synthesized findings of studies on long-term cardiac complications of COVID-19. However, the reporting and methodological quality of these studies has not been systematically evaluated. Here, we ...

    Authors: Boya Guo, Chenya Zhao, Mike Z. He, Camilla Senter, Zhenwei Zhou, Jin Peng, Song Li, Annette L. Fitzpatrick, Sara Lindström, Rebecca C. Stebbins, Grace A. Noppert and Chihua Li
    Citation: BMC Medicine 2023 21:468
  4. The World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) Cancer Prevention Recommendations are lifestyle-based recommendations which aim to reduce cancer risk. This study investigate...

    Authors: Fiona C. Malcomson, Solange Parra-Soto, Frederick K. Ho, Liya Lu, Carlos Celis-Morales, Linda Sharp and John C. Mathers
    Citation: BMC Medicine 2023 21:407

    The Comment to this article has been published in BMC Global and Public Health 2024 2:7

  5. This reconstructed individual patient data (IPD)-based meta-analysis is aimed to summarize the current findings and comprehensively investigate the predictive value of circulating tumor DNA (ctDNA) in operable...

    Authors: Dali Chen, Jinbao Guo, Hao Huang, Lei Tian, Yunbo Xie and Qingchen Wu
    Citation: BMC Medicine 2023 21:467
  6. Each mother–child dyad represents a unique combination of genetic and environmental factors. This constellation of variables impacts the expression of countless genes. Numerous studies have uncovered changes i...

    Authors: Jane W. Y. Ng, Janine F. Felix and David M. Olson
    Citation: BMC Medicine 2023 21:466
  7. Post-radiation nasopharyngeal necrosis (PRNN) is a severe adverse event following re-radiotherapy for patients with locally recurrent nasopharyngeal carcinoma (LRNPC) and associated with decreased survival. Bi...

    Authors: Ting Liu, Di Dong, Xun Zhao, Xiao-Min Ou, Jun-Lin Yi, Jian Guan, Ye Zhang, Lv Xiao-Fei, Chuan-Miao Xie, Dong-Hua Luo, Rui Sun, Qiu-Yan Chen, Lv Xing, Shan-Shan Guo, Li-Ting Liu, Da-Feng Lin…
    Citation: BMC Medicine 2023 21:464

    The Commentary to this article has been published in BMC Medicine 2023 21:465

  8. High rates of discontinuation undermine the effectiveness of adjuvant endocrine therapy (AET) among hormone-receptive breast cancer patients. Patient prognosis also relies on the successful management of cardi...

    Authors: Juliette Artignan, Perrine Capmas, Henri Panjo, Panayotis Constantinou and Nathalie Pelletier-Fleury
    Citation: BMC Medicine 2023 21:463
  9. High-power short-duration (HPSD) ablation strategy has emerged as a popular approach for treating atrial fibrillation (AF), with shorter ablation time. The utilized Smart Touch Surround Flow (STSF) catheter, w...

    Authors: Wei-Jie Chen, Chun-Xia Gan, Yang-Wei Cai, Yang-Yang Liu, Pei-Lin Xiao, Li-Li Zou, Qing-Song Xiong, Fang Qin, Xie-Xin Tao, Ran Li, Hua-An Du, Zeng-Zhang Liu, Yue-Hui Yin and Zhi-Yu Ling
    Citation: BMC Medicine 2023 21:461
  10. Endometriosis is a common, gynaecological disease characterised by the presence of endometrial-like cells growing outside the uterus. Lesions appear at multiple locations, present with variation in appearance,...

    Authors: Sushma Marla, Sally Mortlock, Taija Heinosalo, Matti Poutanen, Grant W. Montgomery and Brett David McKinnon
    Citation: BMC Medicine 2023 21:460
  11. AD16 is a Class 1.1 new drug candidate for Alzheimer’s disease (AD), which has demonstrated potential benefits in AD by reducing neuroinflammation in preclinical studies. Herein, the pharmacokinetics (PK), saf...

    Authors: Daizhuang Peng, Sumei Xu, Ting Zou, Yahui Wang, Wenjuan Ouyang, Yalan Zhang, Chengmei Dong, Dai Li, Jie Guo, Qiuying Shen, Xiaolei Hu, Wenzhi Zhou, Xiaomin Li and Qun Qin
    Citation: BMC Medicine 2023 21:459
  12. Circulating extracellular vesicles (EVs) are increased in preeclampsia (PE) and are associated with severity and progression. We examined in this exploratory cohort study if the mRNAs and long noncoding RNAs (...

    Authors: Tove Lekva, Arvind Y.FM. Sundaram, Marie Cecilie Paasche Roland, June Åsheim, Annika E. Michelsen, Errol R. Norwitz, Pål Aukrust, Gregor D. Gilfillan and Thor Ueland
    Citation: BMC Medicine 2023 21:458
  13. Sex difference exists in the prevalence of dementia and cognitive decline. The impacts of sex-specific reproductive risk factors across the lifespan on the risk of dementia or cognitive decline are still uncle...

    Authors: Shuang-Ling Han, De-Chun Liu, Chen-Chen Tan, Lan Tan and Wei Xu
    Citation: BMC Medicine 2023 21:457
  14. The European Society of Intensive Care Medicine (ESICM) recently recommended changes to the criteria of acute respiratory distress syndrome (ARDS), patients with high-flow oxygen were included, however, the ef...

    Authors: Lina Zhao, Fuhong Su, Nannan Zhang, Hening Wu, Yuehao Shen, Haiying Liu, Xuguang Li, Yun Li and Keliang Xie
    Citation: BMC Medicine 2023 21:456
  15. Selective fetal growth restriction (sFGR) is an extreme complication that significantly increases the risk of perinatal mortality and long-term adverse neurological outcomes in offspring, affecting approximate...

    Authors: Nana Huang, Wei Chen, Hai Jiang, Jing Yang, Youzhen Zhang, Huifeng Shi, Ying Wang, Pengbo Yuan, Jie Qiao, Yuan Wei and Yangyu Zhao
    Citation: BMC Medicine 2023 21:455
  16. Whether cancer risk associated with a higher body mass index (BMI), a surrogate measure of adiposity, differs among adults with and without cardiovascular diseases (CVD) and/or type 2 diabetes (T2D) is unclear...

    Authors: Emma Fontvieille, Vivian Viallon, Martina Recalde, Reynalda Cordova, Anna Jansana, Laia Peruchet-Noray, Hannah Lennon, Alicia K. Heath, Dagfinn Aune, Sofia Christakoudi, Verena Katzke, Rudolf Kaaks, Elif Inan-Eroglu, Matthias B. Schulze, Lene Mellemkjær, Anne Tjønneland…
    Citation: BMC Medicine 2023 21:418
  17. The progression of sleep disturbances remains unclear in patients with early multiple system atrophy (MSA). We aimed to explore the frequency, severity, and coexistence of 2-year longitudinal changes of sleep ...

    Authors: Lingyu Zhang, Yanbing Hou, Chunyu Li, Qianqian Wei, Ruwei Ou, Kuncheng Liu, Junyu Lin, Tianmi Yang, Yi Xiao, Qirui Jiang, Bi Zhao and Huifang Shang
    Citation: BMC Medicine 2023 21:454
  18. The epididymis is crucial for post-testicular sperm development which is termed sperm maturation. During this process, fertilizing ability is acquired through the epididymis-sperm communication via exchange of...

    Authors: Zhuoyao Ma, Jinyu Li, Li Fu, Rong Fu, Ningyuan Tang, Yanmei Quan, Zhixiang Xin, Zhide Ding and Yue Liu
    Citation: BMC Medicine 2023 21:453
  19. Emerging research suggests that attention-deficit/hyperactivity disorder (ADHD) increases the risk for cardiovascular (CVDs) and metabolic disorders (i.e., cardiometabolic disorders) in adulthood. Yet, availab...

    Authors: Maja Dobrosavljevic, Ralf Kuja-Halkola, Lin Li, Zheng Chang, Henrik Larsson and Ebba Du Rietz
    Citation: BMC Medicine 2023 21:452
  20. Widely adopted criteria suggest using either low handgrip strength or poor chair stand performance to identify probable sarcopenia. However, there are limited direct comparisons of these measures in relation t...

    Authors: Jonas Johansson, Sameline Grimsgaard, Bjørn Heine Strand, Avan A. Sayer and Rachel Cooper
    Citation: BMC Medicine 2023 21:451
  21. Leveraging a large nationwide study of Icelandic women, we aimed to narrow the evidence gap around female attention-deficit/hyperactivity disorder (ADHD) and cardiometabolic comorbidities by determining the pr...

    Authors: Unnur Jakobsdottir Smari, Unnur Anna Valdimarsdottir, Thor Aspelund, Arna Hauksdottir, Edda Bjork Thordardottir, Catharina A. Hartman, Pontus Andell, Henrik Larsson and Helga Zoega
    Citation: BMC Medicine 2023 21:450
  22. The immunologic milieu at the maternal–fetal interface has profound effects on propelling the development of the fetal brain. However, accessible epidemiological studies concerning the association between plac...

    Authors: Jixing Zhou, Juan Tong, Xue Ru, Yuzhu Teng, Menglong Geng, Shuangqin Yan, Fangbiao Tao and Kun Huang
    Citation: BMC Medicine 2023 21:449
  23. We test a novel ‘weight scarring’ hypothesis which suggests that past obesity is associated with impairments in current psychological well-being and this increases risk of negative physical health outcomes ass...

    Authors: I Gusti Ngurah Edi Putra, Michael Daly, Angelina Sutin, Andrew Steptoe and Eric Robinson
    Citation: BMC Medicine 2023 21:448
  24. Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are closely related and mutually contribute to the disease’s development. There are many treatment options available to patients. We...

    Authors: Manjun Deng, Yonghao Wen, JingXin Yan, Yichen Fan, Zhixin Wang, Ruixia Zhang, Li Ren, Yinggui Ba, Haijiu Wang, Qian Lu and Haining Fan
    Citation: BMC Medicine 2023 21:447
  25. Vulnerable older adults living with Alzheimer’s disease or Alzheimer’s disease and related dementia (AD/ADRD) and chronic pain generally receive fewer pain medications than individuals without AD/ADRD, especia...

    Authors: Ulrike Muench, Kyung Mi Kim, Zachary Zimmer and Todd B. Monroe
    Citation: BMC Medicine 2023 21:446
  26. Acquired brain injury (ABI) is linked to increased depression risk. Existing therapies for depression in ABI (e.g., cognitive behavioural therapy) have mixed efficacy. Behavioural activation (BA), an intervent...

    Authors: Andrea Kusec, Fionnuala C. Murphy, Polly V. Peers, Ron Bennett, Estela Carmona, Aleksandra Korbacz, Cara Lawrence, Emma Cameron, Andrew Bateman, Peter Watson, Judith Allanson, Pieter duToit and Tom Manly
    Citation: BMC Medicine 2023 21:445
  27. Excess energy intake can lead to metabolic dysfunction-associated steatotic liver disease (MASLD), but the relationship between dietary carbohydrate intake and liver fat content remains unclear. This study aim...

    Authors: Josefina Orliacq, Aurora Pérez-Cornago, Siôn A Parry, Rebecca K Kelly, Dimitrios A Koutoukidis and Jennifer L Carter
    Citation: BMC Medicine 2023 21:444
  28. Metabolite signatures of long-term alcohol consumption are lacking. To better understand the molecular basis linking alcohol drinking and cardiovascular disease (CVD), we investigated circulating metabolites a...

    Authors: Yi Li, Mengyao Wang, Xue Liu, Jian Rong, Patricia Emogene Miller, Roby Joehanes, Tianxiao Huan, Xiuqing Guo, Jerome I. Rotter, Jennifer A. Smith, Bing Yu, Matthew Nayor, Daniel Levy, Chunyu Liu and Jiantao Ma
    Citation: BMC Medicine 2023 21:443
  29. There is growing evidence that substituting animal-based with plant-based foods is associated with a lower risk of cardiovascular diseases (CVD), type 2 diabetes (T2D), and all-cause mortality. Our aim was to ...

    Authors: Manuela Neuenschwander, Julia Stadelmaier, Julian Eble, Kathrin Grummich, Edyta Szczerba, Eva Kiesswetter, Sabrina Schlesinger and Lukas Schwingshackl
    Citation: BMC Medicine 2023 21:404

    The Comment to this article has been published in BMC Global and Public Health 2024 2:3

  30. Waist-to-height ratio (WHtR) has been proposed as a simple and effective screening tool for assessing central obesity and cardiometabolic risk in both adult and pediatric populations. However, evidence suggest...

    Authors: Xin’nan Zong, Roya Kelishadi, Young Mi Hong, Peter Schwandt, Tandi E. Matsha, Jose G. Mill, Peter H. Whincup, Lucia Pacifico, Abel López-Bermejo, Carmelo Antonio Caserta, Carla Campos Muniz Medeiros, Anastasios Kollias, Mostafa Qorbani, Fariborz Sharifian Jazi, Gerda-Maria Haas, Rafael de Oliveira Alvim…
    Citation: BMC Medicine 2023 21:442
  31. Large-scale prevention of respiratory syncytial virus (RSV) infection may have ecological consequences for co-circulating pathogens, including influenza. We assessed if and for how long RSV infection alters th...

    Authors: Naomi R. Waterlow, Jackie Kleynhans, Nicole Wolter, Stefano Tempia, Rosalind M. Eggo, Orienka Hellferscee, Limakatso Lebina, Neil Martinson, Ryan G. Wagner, Jocelyn Moyes, Anne von Gottberg, Cheryl Cohen and Stefan Flasche
    Citation: BMC Medicine 2023 21:441

    The Correction to this article has been published in BMC Medicine 2024 22:128

  32. Creatine is an organic compound that facilitates the recycling of energy-providing adenosine triphosphate (ATP) in muscle and brain tissue. It is a safe, well-studied supplement for strength training. Previous...

    Authors: Julia Fabienne Sandkühler, Xenia Kersting, Annika Faust, Eva Kathrin Königs, George Altman, Ulrich Ettinger, Silke Lux, Alexandra Philipsen, Helge Müller and Jan Brauner
    Citation: BMC Medicine 2023 21:440
  33. Marburg virus disease is an acute haemorrhagic fever caused by Marburg virus. Marburg virus is zoonotic, maintained in nature in Egyptian fruit bats, with occasional spillover infections into humans and nonhum...

    Authors: George Y. Qian, W. John Edmunds, Daniel G. Bausch and Thibaut Jombart
    Citation: BMC Medicine 2023 21:439
  34. Breast cancer is the most commonly diagnosed cancer in women worldwide, and underlying mechanistic pathways associated with breast cancer-specific and non-breast cancer-related deaths are of importance. Emergi...

    Authors: Nina Sophia Decker, Theron Johnson, Johannes A. Vey, Charlotte Le Cornet, Sabine Behrens, Nadia Obi, Rudolf Kaaks, Jenny Chang-Claude and Renée Turzanski Fortner
    Citation: BMC Medicine 2023 21:438
  35. People with hypertension have a higher risk of developing Parkinson’s disease (PD), epidemiological evidence suggests that multiple antihypertensives may affect the occurrence and development of PD with incons...

    Authors: Zeying Feng, Qiuping Zhao, Jingjing Wu, Yiping Yang, Xinru Jia, Junlong Ma, Haibo Tang, Hong Yuan, Guoping Yang and Yao Lu
    Citation: BMC Medicine 2023 21:437
  36. Metabolically healthy obesity is hypothesized to be a benign condition but whether this is the case for dementia remains debated. We examined the role of age at assessment of metabolic-obesity phenotypes in as...

    Authors: Marcos D. Machado-Fragua, Séverine Sabia, Aurore Fayosse, Céline Ben Hassen, Frank van der Heide, Mika Kivimaki and Archana Singh-Manoux
    Citation: BMC Medicine 2023 21:436
  37. Infants born very and extremely premature (V/EPT) are at a significantly elevated risk for neurodevelopmental disorders and delays even in the absence of structural brain injuries. These risks may be due to ea...

    Authors: Kevin M. Cook, Josepheen De Asis-Cruz, Jung-Hoon Kim, Sudeepta K. Basu, Nickie Andescavage, Jonathan Murnick, Emma Spoehr, Melissa Liggett, Adré J. du Plessis and Catherine Limperopoulos
    Citation: BMC Medicine 2023 21:435
  38. The widening of group-level socioeconomic differences in body mass index (BMI) has received considerable research attention. However, the predictive power of socioeconomic position (SEP) indicators at the indi...

    Authors: Liam Wright, Charis Bridger Staatz, Richard J. Silverwood and David Bann
    Citation: BMC Medicine 2023 21:434
  39. Genetics play an important role in risk for cardiometabolic diseases—including type 2 diabetes, cardiovascular disease and obesity. Existing research has explored the clinical utility of genetic risk tools suc...

    Authors: Jing Hui Law, Najia Sultan, Sarah Finer and Nina Fudge
    Citation: BMC Medicine 2023 21:432
  40. Elevated standardised mortality ratio of cardiovascular diseases (CVD) in patients with brain tumours may result from differences in the CVD incidences and cardiovascular risk factors. We compared the risk of ...

    Authors: Michael T. C. Poon, Paul M. Brennan, Kai Jin, Cathie L. M. Sudlow and Jonine D. Figueroa
    Citation: BMC Medicine 2023 21:431
  41. Recent studies have highlighted the role of low-grade systemic inflammation in linking periodontitis to cardiovascular disease (CVD) outcomes, but many aspects remain unclear. This study examines the independe...

    Authors: Christiane Pink, Birte Holtfreter, Henry Völzke, Matthias Nauck, Marcus Dörr and Thomas Kocher
    Citation: BMC Medicine 2023 21:430
  42. Vaccination has played a pivotal role in reducing the burden of COVID-19. Despite numerous studies highlighting its benefits in reducing the risk of severe disease and death, we still lack a quantitative under...

    Authors: Mahan Ghafari, Sepanta Hosseinpour, Mohammad Saeid Rezaee-Zavareh, Stefan Dascalu, Somayeh Rostamian, Kiarash Aramesh, Kaveh Madani and Shahram Kordasti
    Citation: BMC Medicine 2023 21:429
  43. Components of social connection are associated with mortality, but research examining their independent and combined effects in the same dataset is lacking. This study aimed to examine the independent and comb...

    Authors: Hamish M. E. Foster, Jason M. R. Gill, Frances S. Mair, Carlos A. Celis-Morales, Bhautesh D. Jani, Barbara I. Nicholl, Duncan Lee and Catherine A. O’Donnell
    Citation: BMC Medicine 2023 21:384
  44. Research on the association between telomere length (TL) and incident non-alcoholic fatty liver disease (NAFLD) is limited. This study examined this association and further assessed how TL contributes to the a...

    Authors: Linxi Tang, Dankang Li, Yudiyang Ma, Feipeng Cui, Jianing Wang and Yaohua Tian
    Citation: BMC Medicine 2023 21:427
  45. Given the widespread implementation of COVID-19 vaccination to mitigate the pandemic from the end of 2020, it is important to retrospectively evaluate its impact, in particular by quantifying the number of sev...

    Authors: Laetitia Tan-Lhernould, Cynthia Tamandjou, Guilhem Deschamps, Johnny Platon, Cécile Sommen, Fanny Chereau, Isabelle Parent du Châtelet, Simon Cauchemez, Sophie Vaux and Juliette Paireau
    Citation: BMC Medicine 2023 21:426
  46. People need high-quality information to make decisions about research participation. Providing information in written format alone is conventional but may not be the most effective and acceptable approach. We ...

    Authors: Vichithranie W. Madurasinghe, Peter Knapp, Sandra Eldridge, David Collier, Shaun Treweek, Jo Rick, Jonathan Graffy, Adwoa Parker, Chris Salisbury, David Torgerson, Kate Jolly, Manbinder S. Sidhu, Christopher Fife-Schaw, Mark A. Hull, Kirsty Sprange, Elizabeth Brettell…
    Citation: BMC Medicine 2023 21:425
  47. Maternal pre-gestational diabetes (PGDM), gestational diabetes mellitus (GDM), and overweight/obesity have been associated with increased risks of offspring neurodevelopmental conditions (NDCs) including autis...

    Authors: Shuyun Chen, Xi Wang, Brian K. Lee and Renee M. Gardner
    Citation: BMC Medicine 2023 21:422